Results 41 to 50 of about 49,880 (266)

Combining Radiation‐Treated Tumor Vaccines With Mn‐MOF Nanoadjuvants to Amplify Radiation Induced Anti‐Tumor Immune Responses

Advanced Science, EarlyView.
Radiotherapy‐treated tumor membranes are integrated with Mn‐MOF nanoadjuvants to generate Mn@RM, a lymph node‐draining nanovaccine that delivers radiotherapy‐remodeled antigenic components. Mn@RM enhances dendritic cell activation, amplifies T cell‐mediated antitumor immunity, and synergizes with radiotherapy and PD‐1 blockade for combination cancer ...
Yiyu Wang, Qiqi Qi, Dezhong Li, Jingshi Tang, Weifeng Wang, Zushun Xu, Qi Xu, Fangfang Du, Qianyuan He   +8 more
wiley   +1 more source

“We Confess that we are Atheists”

New Blackfriars, 2020
AbstractIn the immortal words of Herbert McCabe, ‘Whatever we are referring to when we use the word “God” it can no more be a god than it can be a model aeroplane or half-past eleven’ (God Still Matters). This striking idea – the “atheism” of true Christianity – has, in fact, a long pedigree.
openaire   +2 more sources

MIS12 Is Required for Kinetochore‐Microtubule Attachment in Oocyte Meiosis

Advanced Science, EarlyView.
A model depicting the role of MIS12 in K‐MT attachment during oocyte meiosis. The presence of MIS12 stabilizes bipolar K‐MT attachments by maintaining the function of NDC80 and its interaction with TUBB. This, in turn, promotes KNL1 assembly and subsequent SAC protein recruitment to kinetochores.
Jian Li, Chun‐Hui Zhang, Yong Wang, Cheng‐Yuan Li, Da‐Rong Wen, Xi Xia, Liang Zhou, Wei‐Ping Qian, Qing‐Yuan Sun, Chang‐Zhong Li   +9 more
wiley   +1 more source

Language and silence: persoonlike herinneringe aan Adam Small, die digter-intellektueel

Tydskrif vir Letterkunde, 2017
’n Algemene publiek, of ten minste ’n Afrikaanse algemene publiek—en in soverre hulle van die wêreld van die lettere kennis neem—sal Adam Small waarskynlik eerstens herken en onthou as digter en dramaturg, en waarskynlik meer spesifiek as die skrywer van
G. J. Gerwel
doaj  

'n Wetenskapsteoretiese benadering tot die voorsiening van mannekrag aan 'n organisasie

SA Journal of Industrial Psychology, 1976
Within an organization as a system, the activities of personnel management form cycli of recurring events which are influenced by energy input. Man is one form of energy input and can by virtue of his creative cognitive powers influence his own role in ...
Joan Meyer
doaj   +1 more source

The KIF6‐RBP Complex Orchestrates mRNA Transport Required for Sperm Flagellar Assembly

Advanced Science, EarlyView.
Two homozygous deleterious KIF6 variants are identified in unrelated men with impaired sperm motility. Mouse models and multi‐omics analyses reveal that KIF6 cooperates with the RNA‐binding proteins FMRP and FXR1 to deliver mRNAs essential for sperm flagellar assembly, linking disrupted mRNA transport to reduced abundance of key structural and ...
Chunbo Xie, Sibing Yi, Xinle Lin, Shen Zhang, Weili Wang, Shimin Yuan, Lanlan Meng, Yong Li, Chen Tan, Chunjia Wei, Yanyan Yu, Yaoqiong Liang, Huan Zhang, Liang Hu, Guangxiu Lu, Wenbin He, Qianjun Zhang, Juan Du, Ge Lin, Chaofeng Tu, Yue‐Qiu Tan   +20 more
wiley   +1 more source

Multi‐regional Organoid Biobank Reveals FAK‐ACSL1‐Driven Doxorubicin‐Resistance and Predictive Biomarkers in Breast Cancer

Advanced Science, EarlyView.
This study established a high‐quality organoid biobank derived from 68 tumor sites across 50 Chinese patients, elucidated the drug sensitivity‐based molecular subtyping in breast cancer, and revealed a novel mechanism of drug resistance mediated by the FAK‐ACSL1 pathway.
Hao Xu, Zhijun Qin, Jiapeng Yang, Baoyuan Zhang, Manqing Cao, Peng Wang, Zaiqi Wang, Jinghui Cheng, Lei Wang, Hong Liu, Hui Yang   +10 more
wiley   +1 more source

Die verkleurmannetjie(s) op Shaka: ’n Vergelyking tussen D. J. Opperman en Thomas Mofolo

Tydskrif vir Letterkunde, 2017
For the purpose of the D. J. Opperman memorial lecture at Stellenbosch the writer took one of this poet’s most well-known credos who maintained under the influence of Keats that the poet should be ‘colourless’, i.e. without any agenda in order to take on
Antjie Krog
doaj  

Die versorging van ons pasiente vanuit ‘n sielkundige oogpunt - feit of legende

Curationis, 1981
Vanweë die feit dat daar tot dusver weining indien enige navorsing in die R.S.A. gedoen is oor die sielkundige versorging van ons pasiente, is dit onmoontlik om ’n bepaalde standpunt in te neem t.o.v. die feit of dit ’n legende is al dan nie.
A.M. Venter
doaj   +1 more source

“We” Are In This Together, But We Are Not One and the Same [PDF]

Journal of Bioethical Inquiry, 2020
AbstractThe COVID-19 pandemic is a man-made disaster, caused by undue interference in the ecological balance and the lives of multiple species. Paradoxically, the contagion has resulted in increased use of technology and digital mediation, as well as enhanced hopes for vaccines and biomedical solutions.
openaire   +7 more sources