Results 101 to 110 of about 1,461,065 (333)

OCTN2 Activates a Non‐Canonical Carnitine Metabolic Pathway to Promote MASH‐HCC Progression and Immunotherapy Resistance

open access: yesAdvanced Science, EarlyView.
In non‐MASH‐HCC, L‐carnitine promotes tumor progression primarily through its classical role in enhancing fatty acid oxidation (FAO). However, in MASH‐HCC, where FAO is markedly suppressed, L‐carnitine shifts from this canonical function to serve instead as an intracellular acetyl group buffer.
Chuqi Xia   +11 more
wiley   +1 more source

Opium for the Masses: How Foreign Free Media Can Stabilize Authoritarian Regimes [PDF]

open access: yes
A common claim in the democratization literature is that foreign free media undermine authoritarian rule. No reliable micro-level evidence on this topic exists, however, since independent survey research is rarely possible in authoritarian regimes and ...
Hainmueller, Jens, Kern, Holger
core   +1 more source

Photothermal–Immunomodulatory Hydrogel Reinforced by Ti3C2/ZnAl‐LDH Nanoplatform for Eradicating MRSA and Promoting Diabetic Wound Healing

open access: yesAdvanced Science, EarlyView.
A NETs‐inspired Ti3C2/LDH hydrogel integrates trapping, ROS boosting, and M2‐immunomodulation for MRSA‐infected wound repair. ABSTRACT MRSA infections give rise to chronic cutaneous and advance into profound tissue invasions, including osteomyelitis and sepsis—conditions for which existing clinical interventions offer only limited efficacy. The utility
Qiang Shi   +6 more
wiley   +1 more source

Structure‐Guided Engineering of a Promiscuous O‐Methyltransferase for a SAM Regeneration Biocatalysis Platform of Methylated Pharmaceuticals

open access: yesAdvanced Science, EarlyView.
A substrate promiscuous and regioselective O‐methyltransferase, SmOMT, is functionally and structurally characterized. A double mutant, SmOMTE152A/I306A, exhibited enhanced catalytic activity. By coupling this mutant with a mutant halide methyltransferase, AtHMTV140T, for SAM regeneration, a superior artificial fusion enzyme, AtHMTV140T‐L95‐SmOMTE152A ...
Xiran Xiong   +11 more
wiley   +1 more source

Review: Ingrid Miethe, Claudia Kajatin & Jana Pohl (Eds.) (2004). Geschlechterkonstruktionen in Ost und West. Biografische Perspektiven [Gender Constructions in East and West. Biographical Perspectives]

open access: yesForum: Qualitative Social Research, 2006
This reader contains analyses of gender constructions in East and West Germany from biographical perspectives. It is based on narrative interviews with women and men living in the former East and West.
Nicola Döring
doaj  

Individual and Work-Related Predictors of Exhaustion in East and West Germany. [PDF]

open access: yesInt J Environ Res Public Health, 2022
Braunheim L   +4 more
europepmc   +1 more source

Cohabiting unions in France and West Germany [PDF]

open access: yes
This paper compares the non-marital birth pattern in France and West Germany. Since the beginning of the eighties, France witnessed a steady increase in non-marital birth rates, while in West Germany non-marital birth rates have remained at a relatively ...
Jean-Marie Le Goff
core  

Single‐Cell Mitochondrial Lineage Tracing Decodes Fate Decision and Spatial Clonal Architecture in Human Hematopoietic Organoids

open access: yesAdvanced Science, EarlyView.
This study repurposes mitochondrial DNA mutations as endogenous barcodes for lineage tracing in human pluripotent stem cell‐derived organoids. Integrated with transcriptomic and spatial data, it reveals NOTCH‐mediated stromal‐progenitor crosstalk orchestrates clonal dynamics and spatial zonation during early hematopoietic development, offering a non ...
Yan Xue   +17 more
wiley   +1 more source

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