Results 91 to 100 of about 8,541 (204)

The anabolic steroid stanozolol is a potent inhibitor of human MutT homolog 1

FEBS Letters, Volume 599, Issue 19, Page 2790-2801, October 2025.
MutT homolog 1 (MTH1) is a member of the NUDIX superfamily of enzymes and is an anticancer drug target. We show that stanozolol (Stz), an anabolic steroid, is an unexpected nanomolar inhibitor of MTH1. The X‐ray crystal structure of the human MTH1–Stz complex reveals a unique binding scaffold that could be utilized for future inhibitor development ...
Emma Scaletti Hutchinson, Robert Gustafsson Westergren, Ingrid Almlöf, Ann‐Sofie Jemth, Martin Scobie, Ulrika Warpman Berglund, Thomas Helleday, Pål Stenmark   +7 more
wiley   +1 more source

The Canine Erythrocyte Sedimentation Rate (ESR): Evaluation of a Point-of-Care Testing Device (MINIPET DIESSE)

Veterinary Medicine International, 2020
The erythrocyte sedimentation rate (ESR) in canine medicine has been replaced by the evaluation of a few sensitive markers of the acute-phase proteins. The aim of the study was to evaluate the ESR using a point-of-care (MINIPET, DIESSE Diagnostica Senese
Carlo Militello, Anna Pasquini, Anyela Andrea Medina Valentin, Petra Simčič, Giulia De Feo, George Lubas   +5 more
doaj   +1 more source

Long-term study of the impact of methotrexate on serum cytokines and lymphocyte subsets in patients with active rheumatoid arthritis: correlation with pharmacokinetic measures [PDF]

, 2016
Objective To describe changes in immune parameters observed during long-term methotrexate (MTX) therapy in patients with active rheumatoid arthritis (RA) and explore correlations with simultaneously measured MTX pharmacokinetic (PKC) parameters ...
Hamilton, Robert, Kremer, Joel M., Lawrence, David A., McInnes, Iain B.   +3 more
core   +1 more source

A Comparative Study On Automated Esr Analyzer And Westergren Manual Method

Journal of Neonatal Surgery
Introduction: Erythrocyte Sedimentation Rate (ESR) measures the rate of sedimentation of erythrocyte in millimeters of an anticoagulated whole blood. It is commonly used to screen for inflammation. This study aims to evaluate the performance of an automated ESR method in comparison with manual Westergren method and assesses its correlation across ...
Priyanka S Priyanka S, Archana S Archana S, Eswari V Eswari V   +2 more
openaire   +1 more source

Ultrasound localization microscopy to image and assess microvasculature in a rat kidney. [PDF]

, 2017
The recent development of ultrasound localization microscopy, where individual microbubbles (contrast agents) are detected and tracked within the vasculature, provides new opportunities for imaging the vasculature of entire organs with a spatial ...
Ferrara, Katherine W, Foiret, Josquin, Ilovitsh, Tali, Mahakian, Lisa, Tam, Sarah, Zhang, Hua   +5 more
core   +3 more sources

Individual Sleep Problems Are Associated With an Accelerated Decline in Multiple Cognitive Functions in Older Adults

Journal of Sleep Research, Volume 34, Issue 5, October 2025.
ABSTRACT Poor sleep is a known risk factor of cognitive disorders, but the role of individual sleep problems in age‐related cognitive changes remains unclear. This study used two complementary statistical models to estimate nonlinear trajectories of decline in four domains of cognitive functioning in the age period between 55 and 100 years depending on
Dina Sarsembayeva, Marieke J. Schreuder, Martijn Huisman, Almar Kok, Maude Wagner, Ana W. Capuano, Catharina A. Hartman   +6 more
wiley   +1 more source

Multifactorial analysis of clinical prognosis in patients with anti‐N‐methyl‐D‐aspartate receptor encephalitis: a single‐centre cohort study

Internal Medicine Journal, Volume 55, Issue 9, Page 1547-1555, September 2025.
Abstract Background This retrospective cohort study investigated the clinical characteristics, treatment regimens and prognostic factors of anti‐N‐methyl‐D‐aspartate receptor (NMDAR) encephalitis in a single‐centre setting between January 2019 and December 2024.
Chunxia Zhao, Han Zhao, Futang Xie, Cao Jiang, Decai Tian, Wangshu Xu, Chen Li   +6 more
wiley   +1 more source

Biochemical profiling of tuberculosis patients co-infected with hepatitis C virus

European Journal of Inflammation, 2017
The present research work was planned to investigate the biochemical parameters in tuberculosis (TB) patients in comparison with healthy individual and TB patients co-infected with hepatitis C virus (HCV).
Yusra Akram, Zahed Mahmood, Muhammad Riaz, Irum Javed, Muhammad Shahid, Tahira Batool, Syed Muhammad Ali Shah, Naveed Munir, Imtiaz Mahmood Tahir   +8 more
doaj   +1 more source

Estimation of disease activity in patients with ankylosing spondylitis in the real practice of a rheumatologist in Russia (Part 2)

Научно-практическая ревматология, 2012
Objective: to compare different methods for estimating ankylosing spondylitis (AS) activity in the real practice of a rheumatologist in the Russian Federation. Subjects and methods.
Evgeny Vladimirovich Volnukhin, E A Galushko, A G Bochkova, A V Smirnov, Sh F Erdes   +4 more
doaj   +1 more source

All-optical characterization of large-signal modulation bandwidth of a monolithically integrated DFB-EA [PDF]

, 2009
We use an all-optical method to characterize the modulation bandwidth of a DFB-EA designed for 100 Gb/s Ethernet. In a large-signal wavelength conversion set-up, we show the device has an all-optical bandwidth of 83 GHz.
Blaaberg, Søren, Chacinski, Marek, Mulvad, Hans Christian Hansen, Oxenløwe, Leif Katsuo, Stoltz, Björn, Westergren, Urban   +5 more
core   +1 more source