Results 141 to 150 of about 247,427 (257)

The Genomics of Isolated Populations of Gampsocleis glabra (Orthoptera: Tettigoniidae) in Central and Western Europe. [PDF]

Insects, 2023
Hawlitschek O, Bruns C, Dey LS, Nuhlíčková S, Felix R, van Kleef H, Nakel J, Husemann M.   +7 more
europepmc   +1 more source

SPSB1 Promotes Subcutaneous Adipose Hyperplasia in Facial Port‐Wine Stains by Controlling HDAC1 Degradation and Stability Through Two Distinct Proteolytic Pathways

Advanced Science, EarlyView.
In PWS‐ASPCs, FOSL1 drives the expression of SPSB1. SPSB1, as part of the ESC complex, further binds to HDAC1 and promotes K29‐linked and K48‐linked polyubiquitination of HDAC1. These modifications facilitate the degradation of HDAC1 through the ALP and UPS pathways, respectively.
Hongrui Chen, Bin Sun, Yajing Qiu, Chen Hua, Xiaoxi Lin, Wei Gao   +5 more
wiley   +1 more source

Metagenomic survey reveals Volzhskoe tick virus in <i>Hyalomma</i> ticks for the first time in western Europe, North-Eastern Spain. [PDF]

One Health
Carrera-Faja L, Jasso MV, Sarmiento I, Cabrera-Gumbau JM, Espunyes J, Martínez-Urtaza J, Cabezón O.   +6 more
europepmc   +1 more source

Genetic diversity and historical demography of underutilised goat breeds in North-Western Europe. [PDF]

Sci Rep, 2023
Manunza A, Ramirez-Diaz J, Cozzi P, Lazzari B, Tosser-Klopp G, Servin B, Johansson AM, Grøva L, Berg P, Våge DI, Stella A.   +10 more
europepmc   +1 more source

An Aggregation‐Induced Polymerization Poly(Disulfide)‐Drug Nanoplatform for Autoimmune Uveitis Therapy via Inhibiting the cGAS‐STING Pathway

Advanced Science, EarlyView.
A cationic poly(disulfide)‐drug nanoplatform (LA/DexP) was developed to treat experimental autoimmune uveitis (EAU). With potent blood‐retinal barrier penetrability, LA/DexP releases DSP in response to high ROS and scavenges cfDNA to inhibit the cGAS‐STING signaling pathway.
Yuelan Wu, Wenbo Geng, Qinjin Dai, Wanyun Zhang, Yuxian Lai, Pei Zhang, Chunjiang Zhou, Yinuo Wang, Qingfeng Cao, Xiang Luo, Yujie Lai, Changwei Huang, Peizeng Yang   +12 more
wiley   +1 more source

Prevalence and Incidence of Dilated Cardiomyopathy in the United States and Western Europe: A Systematic Review. [PDF]

Cardiol Res
Myers MC, Berge A, Zhong Y, Maruyama S, Bueno C, Bastien A, Hofer K, Kaur R, Fazeli MS, Golchin N.   +9 more
europepmc   +1 more source

Concerted Action of Targeted Nucleic Acid Therapeutics as Flexible, Precision and Personalized Cancer Treatment

Advanced Science, EarlyView.
Combinations of small activating RNAs and small interfering RNAs were developed as personalized precision therapies that simultaneously activate tumor suppressors and silence oncogenes according to the molecular signatures of patient tumors. This combination strategy demonstrated superior anticancer efficacy, highlighting the promise of precision ...
Jing Wu, Jiaxuan Chen, Abdechakour Elkihel, Wenjun Lan, Nicolas Fraunhoffer, Dandan Zhu, Baoping Lian, Christina Galanakou, Zhancun Bian, Xi Liu, Odile Gayet, Loic Moubri, Julie Aglietti Roques, Vikash Reebye, Nagy Habib, Xiaoxuan Liu, Nelson Dusetti, Juan Lucio Iovanna, Ling Peng   +18 more
wiley   +1 more source

Trends in myopia prevalence and projected visual impairment in Western Europe: a pooled analysis of Dutch population-based cohorts (1900-2000). [PDF]

BMJ Public Health
Kneepkens S, Enthoven CA, Polling JR, de Vries VA, Tideman JWL, Klaver C, Eye Epidemiology research group.   +6 more
europepmc   +1 more source

Systematic Multi‐Level Analyses Decode the Arthritis‐Neurodegeneration Axis With In Vivo Validation

Advanced Science, EarlyView.
Arthritis and neurodegeneration are usually studied as separate disorders, but this study connects them through population evidence, genetic inference, transcriptomic mapping, and mouse models. It highlights RNF40 as a context‐dependent joint‐brain candidate, induced in inflammatory joints yet functionally linked to dopamine‐neuron vulnerability ...
Jinwen Wang, Wenhui Xie, Lei Yang, Zhengrong Wang, Yi Huang, Peng Huang, Yuan Liu, Jun Hu   +7 more
wiley   +1 more source

Tabes dorsalis: a rare presentation of neurosyphilis in Western Europe. [PDF]

BMJ Case Rep
Bloch N, Brugger F, Notter J.
europepmc   +1 more source