Results 191 to 200 of about 2,888,670 (301)

Trends in myopia prevalence and projected visual impairment in Western Europe: a pooled analysis of Dutch population-based cohorts (1900-2000). [PDF]

BMJ Public Health
Kneepkens S, Enthoven CA, Polling JR, de Vries VA, Tideman JWL, Klaver C, Eye Epidemiology research group.   +6 more
europepmc   +1 more source

Tumor‐Specific Delivery of CD28 siRNA via Lyso‐PC C‐16 Modified Lipid Nanoparticles Overcomes Anti‐PD‐1 Resistance by Remodeling Tumor Microenvironment

Advanced Science, EarlyView.
This study develops 16:0 LPC‐modified lipid nanoparticles (LPC‐LNPs) with cancer cell specificity by exploiting altered tumor lipid metabolism. LPC‐LNPs encapsulating Cd28 small interfering RNA (LPC‐LNP‐Cd28) knock down cancer cell CD28 without affecting T cells, inflame the tumor microenvironment, and overcome anti‐PD‐1 resistance.
Yangyang Chai, Keyu Wang, Jiali Fang, Shaorui Jia, Yansong Shi, Wanfeng Gao, Xinpeng Liu, Jiaqiang Li, Zenghui Cui, Yazhi Qian, Xiaosu Chen, Dan Ding, Xuetao Cao   +12 more
wiley   +1 more source

Prevalence and Incidence of Dilated Cardiomyopathy in the United States and Western Europe: A Systematic Review. [PDF]

Cardiol Res
Myers MC, Berge A, Zhong Y, Maruyama S, Bueno C, Bastien A, Hofer K, Kaur R, Fazeli MS, Golchin N.   +9 more
europepmc   +1 more source

Targeting DNGR‐1 with Fangchinoline Elevates Dendritic Cell Antigen Cross‐Presentation‐Mediated Antitumor Immunity in Melanoma

Advanced Science, EarlyView.
Fangchinoline is identified as a small‐molecule DNGR‐1 modulator that enhances dendritic‐cell cross‐presentation of tumor antigens. By engaging DNGR‐1 and activating Syk–Nox2 signaling, it promotes phagosomal ROS, antigen escape, MHC‐I presentation, and CD8+ T‐cell priming, thereby strengthening antitumor immunity and sensitizing tumors to PD‐1 ...
Yuan Liao, Zhenyang Ren, Jing Zhou, He Luo, Yuling Li, Dan Chen, Yuxiao Jiang, Canzhe Li, Mengyi Zheng, Anqi Li, Yao Wang, Yang Zhang, Dingye Wang, Yanjun Jiang, Jiangyong Gu, Biaoyan Du, Yafei Shi, Fang Liu, Jianyong Xiao, Kun Wang   +19 more
wiley   +1 more source

Climate Change Does Not Directly Influence Red Squirrel ( <i>Sciurus vulgaris</i> ) Distribution in Western Europe. [PDF]

MicroPubl Biol
Buchanan AEV, Gillingham PK, Andreou D, Hodder KH, Toups MA, Butler H, Hardouin EA.   +6 more
europepmc   +1 more source

A Highly Hydrophilic Air Electrode With Water‐Induced Surface Reconstruction for Efficient Reversible Protonic Ceramic Cell at Low Water Partial Pressures

Advanced Energy Materials, EarlyView.
This work demonstrates a new strategy for reversible protonic ceramic cells (R‐PCCs). By developing highly hydrophilic oxides, efficient operation is achieved under low water vapor pressures while maintaining high performance and stability. This approach addresses the challenge of hydrogen production in freshwater‐scarce regions.
Nai Shi, Yun Xie, Xueyu Hu, Junji Hyodo, Chun‐Kuo Peng, Gaopeng Zhou, Hanwen Liu, Bingbing Qiu, Daqin Guan, Jiayi Tang, Yan‐Gu Lin, Ranran Peng, Moses Oludayo Tadé, Meilin Liu, Yoshihiro Yamazaki, Zongping Shao   +15 more
wiley   +1 more source

Tabes dorsalis: a rare presentation of neurosyphilis in Western Europe. [PDF]

BMJ Case Rep
Bloch N, Brugger F, Notter J.
europepmc   +1 more source

Sustainable Productivity Growth in Agriculture: The Role of Shifts in R&D Investments and Technology

Applied Economic Perspectives and Policy, EarlyView.
ABSTRACT The objective of the paper is to evaluate the long‐term prospects of sustainable productivity growth linked to plausible assumptions on public agricultural R&D investments as the key productivity driver. Second, it investigates the role of changing R&D focus from yield maximization to input saving technologies (fertilizers and pesticides). The
Zuzana Smeets Křístková, Michiel van Dijk, Robert M'Barek, Hans van Meijl, Tomas Ratinger   +4 more
wiley   +1 more source

Developing an Adult Living Donor Liver Transplant Program in Western Europe: The Rotterdam Experience. [PDF]

Transpl Int
Chorley AJ, Polak WG, Tran KCK, Terkivatan T, Kissler J, Doukas M, Den Hoed C, Thomeer MG, Dwarkasing R, Metselaar H, Ijzermans JNM, Porte RJ, Kuipers EJ, Minnee RC, Boehnert M.   +14 more
europepmc   +1 more source

Crop Insurance Design and On‐Farm Risk Adaptation

Applied Economic Perspectives and Policy, EarlyView.
ABSTRACT The United States spends billions annually on crop insurance premium subsidies, yet the prevailing distance‐based guarantee design unintentionally rewards risk‐taking by linking subsidies to yield variability. We consider a simple redesign: define guarantees in terms of probability so that coverage reflects a consistent likelihood of indemnity.
Gerald Van Tassell, Alan P. Ker
wiley   +1 more source