Results 221 to 230 of about 4,267,500 (287)

Avoidable mortality does not allow valid conclusions on population health and health system quality in Western Europe-authors' reply. [PDF]

Lancet Reg Health Eur
Hrzic R, Vogt T, Pearcy P, Kyriopoulos I, Mossialos E.   +4 more
europepmc   +1 more source

Targeting Mitochondrial Redox Signaling Promotes Neuroregeneration and Functional Recovery in a Multiple Sclerosis Model

Advanced Science, EarlyView.
Modulation of mitochondrial redox signaling by furapyrrodole activates CYB5R3 and suppresses Notch signaling, unlocking the regenerative potential of endogenous neural progenitor cells. This approach promotes neurogenesis, oligodendrogenesis, and remyelination, thereby improving neuronal function in a mouse model of multiple sclerosis and identifying ...
Yuki Narushima, Joshua Saylor, Shun Saito, Jinyan Zhou, Haruka Kawano, Shehata Anwar, Haruki Oba, Rachel Huezo, Miyu Okano, Haruki Matsuda, Makoto Kawatani, Kaori Honda, Hiroyuki Osada, Yuta Kikuchi, Masahito Ohue, Masami Ishibashi, Takayoshi Arai, Makoto Inoue, Midori A. Arai   +18 more
wiley   +1 more source

PHGDH‐Mediated Serine Metabolism in Nucleus Pulposus Cells Is a Potential Therapeutic Target for Intervertebral Disc Degeneration

Advanced Science, EarlyView.
When nucleus pulposus cells senesce, PHGDH decreases, reducing serine synthesis and glutathione, impairing antioxidant capacity. The intermediate α‐KG also drops, lowering JMJD3 demethylase activity, increasing H3K27me3 at the Rap1b promoter, and reducing Rap1b expression, whose down‐regulation in turn activates mTORC1 and suppresses autophagy ...
Hao‐Wei Xu, Sheng‐Jie Chang, Xiao‐Wei Liu, Shu‐Bao Zhang, Ying‐Jie Wang, Shan‐Jin Wang   +5 more
wiley   +1 more source

Genetic admixture between East and West European Gravettian-associated populations in Western Europe before the Last Glacial Maximum

Gelabert P, Sawyer S, Cheronet O, Villalba-Mouco V, Oberreiter V, González-Morales MR, Straus LG, Gutiérrez-Zugasti I, Cuenca-Solana D, Gárate D, Marín-Arroyo AB, de Lumley H, Tejero J, Normand C, Darricau J, Lucci M, Nava A, Genchi F, Coppola D, Marca CL, Higham T, Giannì M, van der Sluis LG, Gómez-Montes C, Hämmerle M, Zagorc B, Exler F, Brück F, Franz S, Cano FT, Stewardson K, Qiu L, Stahlschmidt M, Coppa A, Reich D, Pinhasi R.   +35 more
europepmc   +1 more source

Maternal Socioeconomic Status and the Initiation and Duration of Breastfeeding in Western Europe Versus Southern Africa: A Systematic Review-A Contribution from the ConcePTION Project. [PDF]

Nutrients
Van Neste M, Verschoren K, Kempenaers R, Eerdekens A, Kitshoff D, Allegaert K, Bogaerts A.   +6 more
europepmc   +1 more source

Regional Differences in U.S. Consumer Preferences for Native Woody Shrubs With Varying Aesthetic Characteristics

Agribusiness, EarlyView.
ABSTRACT Native plants offer a variety of aesthetic (e.g., fall colour, fruit, flowers) and functional benefits (e.g., pollinator friendly, wildlife friendly, water management). How these benefits influence consumer choice and perceived value of native versus introduced plants is not well understood.
Alicia Rihn, Ariana P. Torres, Sue Barton, Bridget K. Behe   +3 more
wiley   +1 more source

Heat and Drought Events Alter Biogenic Capacity to Balance CO₂ Budget in South-Western Europe. [PDF]

Global Biogeochem Cycles
Segura-Barrero R, Lauvaux T, Lian J, Ciais P, Badia A, Ventura S, Bazzi H, Abbessi E, Fu Z, Xiao J, Li X, Villalba G.   +11 more
europepmc   +1 more source

Genesis and Spread of Novel Highly Pathogenic Avian Influenza A(H5N1) Clade 2.3.4.4b Virus Genotype EA-2023-DG Reassortant, Western Europe. [PDF]

Emerg Infect Dis
Van Borm S, Ahrens AK, Bachofen C, Banyard AC, Bøe CA, Briand FX, Dirbakova Z, Engelsma M, Fusaro A, Germeraad E, Gjerset B, Grasland B, Harders F, Hostyn P, Kauppinen A, Lambrecht B, Mollett BC, Monne I, Nagy A, Pohlmann A, Polzer D, Reid SM, Revilla-Fernandez S, Steensels M, Stätter M, Swieton E, Tammiranta N, Wyler M, Zecchin B, Zohari S, Dellicour S.   +30 more
europepmc   +1 more source

Isotope and morphometrical evidence reveals the technological package associated with agriculture adoption in western Europe. [PDF]

Proc Natl Acad Sci U S A
Araus JL, Gascón M, Ros-Sabé E, Piqué R, Rezzouk FZ, Aguilera M, Voltas J, Peña-Chocarro L, Pérez-Jordà G, Terradas X, Palomo A, Ferrio JP, Antolín F.   +12 more
europepmc   +1 more source