Results 191 to 200 of about 24,556 (268)

NSD2 Coordinates the Neurogenic‐to‐Gliogenic Transition via H3K36me2‐Dependent Activation of the EGFR‐ERK Pathway

Advanced Science, EarlyView.
NSD2 coordinates the neurogenic‐to‐gliogenic transition in the developing neocortex through H3K36me2‐dependent activation of EGFR–ERK signaling. Loss of NSD2 disrupts astroglial and oligodendroglial development, whereas ERK activation rescues gliogenic defects in vitro and in vivo.
Hanxue Chen, Mengyuan Li, Lin Hou, Bin Yin, Boqin Qiang, Ran Gao, Pengcheng Shu, Xiaozhong Peng   +7 more
wiley   +1 more source

Isotopic evidence for human adaptation to island environments in the Canary Islands during the Amazigh period. [PDF]

Sci Rep
Sánchez-Cañadillas E, Morquecho Izquier A, Smith C, Iriarte E, Santana J.   +4 more
europepmc   +1 more source

SPSB1 Promotes Subcutaneous Adipose Hyperplasia in Facial Port‐Wine Stains by Controlling HDAC1 Degradation and Stability Through Two Distinct Proteolytic Pathways

Advanced Science, EarlyView.
In PWS‐ASPCs, FOSL1 drives the expression of SPSB1. SPSB1, as part of the ESC complex, further binds to HDAC1 and promotes K29‐linked and K48‐linked polyubiquitination of HDAC1. These modifications facilitate the degradation of HDAC1 through the ALP and UPS pathways, respectively.
Hongrui Chen, Bin Sun, Yajing Qiu, Chen Hua, Xiaoxi Lin, Wei Gao   +5 more
wiley   +1 more source

Extreme Arabian environments and their microbiomes: new frontiers for astrobiology and biosignature discovery. [PDF]

Extremophiles
Schultz J, García-Martínez PM, Altalhi S, Kontis N, Dos Santos A, Rosado AS.   +5 more
europepmc   +1 more source

A Second Pathogenic Protein, PolyGN2C‐iso2, Reveals a Dual‐Protein Pathology in Neuronal Intranuclear Inclusion Disease

Advanced Science, EarlyView.
This study reveals that NOTCH2NLC transcript variant 2 generates PolyGN2C‐iso2, an aggregating protein present within intranuclear inclusions of NIID patient tissues. A novel mouse model expressing PolyGN2C‐iso2 recapitulates white matter abnormalities and cognitive deficits, mechanistically linked to mitochondrial dysfunction. These findings support a
Kang Zhang, Wenhao Ma, Yi Zhou, Zhijie Wu, Pan Gao, Hongze Niu, Hongfei Tai, Tianyi Zhao, Zheyue Dong, Li Li, Yan Zhang, An Wang, Si Shen, Yueyang Li, Sifei Yu, Yan Peng, Wang Sheng, Xiaoyan Dong, Hua Pan, Kaibin Shi, Magdalena J. Koziol, Xiaobing Wu, Zaiqiang Zhang   +22 more
wiley   +1 more source

Soil-plant interactions and metal uptake efficiency of native species in phosphate mining-affected environments. [PDF]

BMC Plant Biol
Ramadan S, Rizwan M, Al-Balawi SM, Elshamy MM.   +3 more
europepmc   +1 more source

Evaluation of plant diversity and soil-vegetation relationships in some salinity-affected cultivated areas in Egypt. [PDF]

PLoS One
Abou Glida E, Mohamed Ragab AA, Ahmed Khafagi OM, Bedair R.   +3 more
europepmc   +1 more source

Potential patterns of fall armyworm seasonal migration in West Africa modeled with atmospheric trajectory analyses. [PDF]

Pest Manag Sci
Gao FQ, Zhang XY, Kyerematen R, Hu G, Early R, Chapman JW.   +5 more
europepmc   +1 more source

Dust storms: Hidden drivers of extreme rainfall and global precipitation shifts. [PDF]

Sci Adv
Liu Y, Tang W, Shao T, Luo R, Tan Z, Li D, Huang J.   +6 more
europepmc   +1 more source

Characterization of the Wild Trees and Shrubs in the Fergana Valley: Diversity and Distribution, Threats. [PDF]

Ecol Evol
Daminova N, Huang XH, Hoshimov HR, Makhmudjanov D, Karimov FI, Gil HY, Tojibaev KS, Choi HJ.   +7 more
europepmc   +1 more source