Results 61 to 70 of about 339,117 (350)

Associations of Rheumatoid Arthritis Disease Activity With Frailty Over Five Years of Follow‐up

Arthritis Care &Research, EarlyView.
Objective To evaluate whether rheumatoid arthritis (RA) disease activity is associated with frailty both in cross‐section and longitudinally. Methods Participants within the Veterans Affairs Rheumatoid Arthritis (VARA) registry enrolled from 2003 to 2022 were included.
Courtney N. Loecker, Yangyuna Yang, Punyasha Roul, Aaron Baraff, Myra S. Schmaderer, Lani Zimmerman, Kaleb Michaud, Namrata Singh, Grant W. Cannon, Gary Kunkel, Ted R. Mikuls, Ariela R. Orkaby, Joshua F. Baker, Bryant R. England, Katherine D. Wysham   +14 more
wiley   +1 more source

Variation Trends of Asymmetrical Precipitable Water Vapor Outside the Tropical Cyclone Center Over the WNP and WSP Ocean

Geophysical Research Letters, 2023
Precipitable water vapor (PWV) is one of the crucial driving forces for tropical cyclone (TC) genesis. Under the impact of global warming, TCs have changed their way to concentrate PWV from the ambient atmosphere.
Shiwei Yu, Zhizhao Liu, Yuanjian Yang
doaj   +1 more source

A Bifunctional T3SS‐Effector Simultaneously Cleaves Host MAP Kinase and Inhibits PPM1A Phosphatase

Advanced Science, EarlyView.
Pathogenic bacteria exploit the metalloprotease effector NleD to subvert host defenses. Structural, biochemical, and infection analyses reveal a bifunctional mechanism by which NleD binds and inhibits the host phosphatase PPM1A while preserving its proteolytic activity against MAPKs.
Yaakov Socol, Lihi Gur‐Arie, Netanel Tzarum, Tamara Wellins, Naama Katsowich, Miriam Ravins, Michal Bejerano‐Sagie, Klil Cohen, Oded Livnah, Joshua N. Adkins, Ernesto Nakayasu, Alexei Savchenko, Yeu Khai Choong, Nikhil Kumar Tulsian, Saturo Machida, Sigal Ben‐Yehuda, Yael Litvak, J. Sivaraman, Ilan Rosenshine   +18 more
wiley   +1 more source

DNA Replication Errors Drive Genome‐Wide Small Inverted Triplication Dynamics

Advanced Science, EarlyView.
This study provides insight into the dynamic equilibrium mechanism of a novel structural variant, small inverted triplication (SIT), which is generated by misalignment of the 3’ flap generated under DNA replication stress with palindromic sequence. Alternatively, the end sequence may fold back on itself to form an inverted fragment.
Yi Lei, Yu Zhou, Haitao Sun, Hang Yuan, Xinyu Pei, Jessica D. Hess, Yao Yan, Zunsong Hu, Mian Zhou, Zhaohui Gu, Li Zheng, Xiwei Wu, Binghui Shen   +12 more
wiley   +1 more source

Future dynamic sea level change in the western subtropical North Pacific associated with ocean heat uptake and heat redistribution by ocean circulation under global warming

Progress in Earth and Planetary Science, 2020
In the present study, the relative importance of ocean heat uptake and heat redistribution on future sea level changes in the western North Pacific has been reconciled based on a set of climate model experiments in which anomalous surface fluxes of wind ...
Tatsuo Suzuki, Hiroaki Tatebe
doaj   +1 more source

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source

The Comparison of the Tropical Cyclone Number Over the Western North Pacific Between Summer and Autumn

Frontiers in Earth Science, 2020
Based on the observational evidences that the tropical cyclones (TCs) number in the western North Pacific (WNP) in autumn is more than that in summer, this study mainly compares the disturbance of some conditions that associated with the formation of TCs
Jia Liu, Zhifan Chen, Jiang Li
doaj   +1 more source

Sustainable Productivity Growth in Agriculture: The Role of Shifts in R&D Investments and Technology

Applied Economic Perspectives and Policy, EarlyView.
ABSTRACT The objective of the paper is to evaluate the long‐term prospects of sustainable productivity growth linked to plausible assumptions on public agricultural R&D investments as the key productivity driver. Second, it investigates the role of changing R&D focus from yield maximization to input saving technologies (fertilizers and pesticides). The
Zuzana Smeets Křístková, Michiel van Dijk, Robert M'Barek, Hans van Meijl, Tomas Ratinger   +4 more
wiley   +1 more source

Diversity of cross-Pacific atmospheric river main routes

Communications Earth & Environment
Atmospheric rivers distribute heterogeneously over the North Pacific. Here, we identify five cross-Pacific atmospheric river main routes (i.e., preferred migratory path) by Self-organizing map automatically.
Mengxin Pan, Mengqian Lu, Upmanu Lall
doaj   +1 more source

Quasi-biennial modulation of rapidly intensifying tropical cyclones by the western North Pacific monsoon

Environmental Research Communications, 2023
Previous publications have highlighted the relationship between several climate modes such as El Niño–Southern Oscillation and tropical cyclones (TCs) experiencing rapid intensification (RI) over the western North Pacific (WNP), particularly on a 3–7-yr ...
Jinjie Song, Philip J Klotzbach, Qingyuan Liu, Yihong Duan   +3 more
doaj   +1 more source