Results 291 to 300 of about 174,007 (375)

BMP‐Dependent Modulation of ROS Generation and Scavenging Controls Interdigital Cell Death

Development, Growth &Differentiation, EarlyView.
BMP signaling regulates ROS generation and scavenging to control interdigital cell death in the developing chicken limb, highlighting a balance between oxidative stress and tissue regression. ABSTRACT Programmed cell death during embryonic development plays a vital role in shaping limb morphology in amniotes.
Satomi F. Ono, Rikito Furukawa, Ingrid Rosenburg Cordeiro, Kaori Kabashima, Kyohei Yoshida, Taiki Hatano, Koki Hayafune, Makoto Kashima, Akiha Kagehira, Reiko Yu, Toru Kawanishi, Mikiko Tanaka   +11 more
wiley   +1 more source

Evaluation of thermal desorption-electrospray ionization mass spectrometry for characterization of <i>Mycobacterium tuberculosis</i>: Comparison with MIRU-VNTR and whole-genome sequencing. [PDF]

J Mass Spectrom Adv Clin Lab
Yang TY, Su H, Jain SH, Lin HH, Wu CY, Chen CJ, Shiea J, Lu PL.   +7 more
europepmc   +1 more source

Haploinsufficiency of brain‐specific kinase BRSK1 causes epilepsy and neurodevelopmental disorders

Epilepsia, EarlyView.
Abstract Objective The BRSK1 gene encodes brain‐specific serine/threonine kinase 1 (also known as SAD‐B kinase), which is almost exclusively expressed in the brain and plays critical roles in neuronal polarization, neurotransmitter release, mitochondrial dynamics, and neuronal maturation.
Qi Zhang, Hiroshi Yamanaka, Ping Li, Yingfeng Li, Tian Luo, Miao Xia, Ting Liu, Xueyan Liu, Qing Lu, Bin Yang, Fan He, Kaixian Du, Yousheng Shu, Bo Peng, Yong‐hui Jiang, Yi Wang   +15 more
wiley   +1 more source

A chromosome-scale assembly of Ormosia boluoensis (Fabaceae). [PDF]

Sci Data
Zhu JP, Wang ZF, Cheng F, Yu EP, Fu L, Zeng YN, Huang YM, Chen XG, Deng SW, Zhang Y, Deng JM, Lin HH, Zhu WG, Xu FX, Cao HL.   +14 more
europepmc   +1 more source

Correlation of epidemiological data with WGS.

, 2016
Nicola Casali, Agnieszka Broda, Reid Simon, P. T. Higgins Julian, B. Hallett Timothy, Francis Drobniewski   +5 more
openalex   +2 more sources

Penetrance of pathogenic epilepsy variants is low and shaped by common genetic background

Epilepsia, EarlyView.
Abstract Objective The identification of pathogenic variants in developmental epileptic encephalopathy (DEE) genes can be vital for counseling and individualized treatment. Penetrance is usually considered to be high or full, although this has never been studied in population cohorts.
Remi Stevelink, M. Martijn Piet, Yorgos Bos, Ruben van ’t Slot, Kees P. J. Braun, Bobby P. C. Koeleman   +5 more
wiley   +1 more source

Decoding structural birth defects through genomic landscapes: Innovative frameworks for diagnosis (Review). [PDF]

Int J Mol Med
Xu R, Ren H, Yuan Z, Huang W, Gu H.
europepmc   +1 more source

Unwelcome neighbours: Tracking the transmission of Streptococcus equi in the United Kingdom horse population

Equine Veterinary Journal, EarlyView.
Abstract Background Strangles (Streptococcus equi infection) remains endemic in the UK, with ~300 laboratory diagnoses annually. Sub‐clinically infected long‐term carriers are considered a key driver of endemicity. Analysing genomes of circulating strains could provide valuable transmission insights of this pathogen.
Abigail A. McGlennon, Kristien L. Verheyen, J. Richard Newton, Andries van Tonder, Hayley Wilson, Julian Parkhill, Nicolas de Brauwere, Sara Frosth, Andrew S. Waller   +8 more
wiley   +1 more source

Cell-free DNA-based inference of the activities of 370 + transcription factors mirrors their activities in tumors. [PDF]

BMC Genomics
Tamaki R, Sagane K, Li SD, Hoshi T.
europepmc   +1 more source

A patient‐derived orthotopic xenograft model unveils metastatic dynamics in head and neck squamous cell carcinoma

The FEBS Journal, EarlyView.
Metastasis in head and neck squamous cell carcinoma (HNSC) poses significant clinical challenges. This proof‐of‐concept study establishes patient‐derived orthotopic xenografts (PDOXs) as advanced models that closely replicate primary HNSC tumours, including local lymph node metastasis and the intricate cancer–stroma interaction.
Yuchen Bai, Benjamin Blyth, Jarryd Boath, Qiji Deng, Ruihong Huang, Charbel Darido   +5 more
wiley   +1 more source