Results 111 to 120 of about 13,938 (303)

Humanized and Charge‐Optimized CSPG4‐Specific CAR‐T Cells show Enhanced Efficacy against Head and Neck Squamous Cell Carcinoma

Advanced Science, EarlyView.
CSPG4 is identified as a high‐value, stemness‐associated target in HPV‐negative HNSCC. By implementing rational biophysical engineering, a humanized and charge‐optimized CAR is developed to overcome tonic signaling‐induced exhaustion. This strategy induces a profound transcriptomic shift toward a rejuvenated, stem‐like memory state, significantly ...
Xiang Xu, Shizhen Qiu, Zhitong Wang, Dan Li, Min Chen, Yinying Chu, Guangfei Li, Yi Fang, Changjiang Li, Fang Shi, Peijie He, Haitao Wu, Haopeng Wang, Jian Chen   +13 more
wiley   +1 more source

A NeuroD1 AAV‐Based Gene Therapy for Functional Brain Repair in Alzheimer's Disease‐Like Non‐Human Primate Model

Advanced Science, EarlyView.
This study tests NeuroD1 AAV‐based gene therapy in a non‐human primate Alzheimer's disease model. The therapy prevents neuronal damage, inhibits hippocampal atrophy, and reduces neuroinflammation. It also repairs vascular and blood‐brain barrier damage, restores cerebrospinal fluid biomarkers, enhances hippocampal glucose metabolism, and improves ...
Zhouquan Jiang, Yongpeng Qin, Bin Luo, Fan Bai, Jiangyue Liu, Long Ma, Shu He, Rongjie Chen, Yuchen Wang, Shanggong Liu, Ying Sun, Yi Chen, Shuo Zhang, Jiaqi Liang, Feng Liao, Huiyi Wei, Junjie Wei, Lu Wang, Hao Xu, Zheng Wu, Gong Chen, Wenliang Lei   +21 more
wiley   +1 more source

Asymmetries in Fragments [PDF]

, 2010
This paper discusses the asymmetries with respect to island-sensitivity between two types of fragment answers : fragment answers to wh-questions, on the one hand, and fragments that derive from stripping, which in turn involves focus-movement, on the ...
NISHIGAUCHI Taisuke, Taisuke NISHIGAUCHI
core  

Passivation‐Induced Species Dynamics and Microstructural Evolution in Solid‐State Lithium–Sulfur Cathodes

Advanced Science, EarlyView.
The formation of insulating Li2S during discharge in solid‐state lithium–sulfur batteries passivate reaction sites and limits sulfur utilization. In this work, a microstructure‐resolved modeling framework coupling transport and reaction kinetics is developed to predict charge–discharge behavior and reveal particle‐scale species evolution and incomplete
Arpan K. Sharma, Bairav S. Vishnugopi, Elif Pınar Alsaç, Matthew T. McDowell, Partha P. Mukherjee   +4 more
wiley   +1 more source

Dual input and learnability: Null objects in Cantonese-English bilingual children [PDF]

, 2005
published_or_final_versio
Matthews, SJ, Yip, V
core   +1 more source

CD28‐Targeted Enzyme‐Responsive Conformation‐Switching Peptide Self‐Assembly for Selective T‐Cell Acute Lymphoblastic Leukemia (T‐ALL) Therapy

Advanced Science, EarlyView.
We developed the enzyme‐responsive peptide SAp‐CD28 to selectively target CD28‐overexpressing T‐ALL cells. Following phosphatase‐mediated activation, SAp‐CD28 undergoes conformational switching and nanooligomerization, resulting in the disruption of CD28 downstream signaling.
Jun Li, Ziyu Jia, Dekun Li, Zhi‐Wen Hu, Yinghao Ding, Shengyi Zhang, Shengkun Tuo, Zhimou Yang, Huisheng Fu, Ling Wang, Man‐Di Wang   +10 more
wiley   +1 more source

Synergistic Ion Transport and Spatial Confinement in Sb‐Embedded Hollow Carbon Nanofibers for Stable Na Metal Anodes

Advanced Science, EarlyView.
This work presents a 3D Sb‐embedded hollow carbon nanofiber (Sb@HCF) host for ultra‐stable Na metal anodes. Experimental analyses and theoretical simulations clearly uncovers that in situ formed Na‐Sb alloy guides uniform Na deposition and serves as efficient ion transport highways. The Sb@HCF‐based cells achieve exceptional cycling stability in half‐,
Feng Han, Menghuan Yuan, Hui Wang, Baitao Liu, Dezhi Kong, Yongtao Tian, Xinjian Li, Ye Wang, Tingting Xu, Hui Ying Yang   +9 more
wiley   +1 more source

Detection and Mapping of Water Hyacinth Growth Cycle in Anzali International Wetland Using Sentinel-2 Time Series

IEEE Journal of Selected Topics in Applied Earth Observations and Remote Sensing
Water hyacinth (WH) is a notorious invasive species that significantly threatens ecosystems worldwide. Despite WH's well-documented threats and effects, its spatial distribution is not yet fully understood, especially in complex environments such ...
Mehran Alizadeh Pirbasti, Vahid Akbari, Deepayan Bhowmik, Maharaj Savitri, Armando Marino   +4 more
doaj   +1 more source

Scrambling in German and Japanese: adjunction versus multiple specifiers [PDF]

, 2002
This paper argues that short (clause-internal) scrambling to a pre-subject position has A properties in Japanese but A'-properties in German, while long scrambling (scrambling across sentence boundaries) from finite clauses, which is possible in Japanese
Grewendorf, Günther, Sabel, Joachim
core  

Atomic Defects in Layered Transition Metal Dichalcogenides for Sustainable Energy Storage and the Intelligent Trends in Data Analytics

Advanced Science, EarlyView.
This review comprehensively summarizes the atomic defects in TMDs for their applications in sustainable energy storage devices, along with the latest progress in ML methodologies for high‐throughput TEM data analysis, offering insights on how ML‐empowered microscopy facilitates bridging structure–property correlation and inspires knowledge for precise ...
Zheng Luo, Ying Yang, Zizhen Fu, Fengqi Liu, Susu Fang, Kele Xu, Shanshan Wang   +6 more
wiley   +1 more source