Results 161 to 170 of about 671,029 (296)

CCT2 Promotes Prostate Cancer Progression Through EIF3F‐Dependent Stabilization of FASN

open access: yesAdvanced Science, EarlyView.
ABSTRACT Prostate cancer (PCa) is increasingly recognized to be driven by dysregulated lipid metabolism. Although fatty acid synthase (FASN) is highly expressed in PCa, the mechanisms governing FASN protein stability and its functional integration into oncogenic lipid metabolism remain poorly defined.
Shun Xu   +13 more
wiley   +1 more source

Targeting Lactate‐Driven Stromal Autophagy via MCT1 Disrupts the Immunosuppressive Niche and Sensitizes Pancreatic Cancer to PD‐1 Blockade

open access: yesAdvanced Science, EarlyView.
Tumor‐derived lactate activates PSCs through MCT1‐mediated Vps34 lactylation and autophagy. These activated PSCs secrete CXCL9/10, upregulating PD‐1 on CD8+ T cells via the CXCR3/STAT3 axis to foster immunosuppression. Disrupting this metabolic crosstalk by targeting MCT1 effectively sensitizes pancreatic cancer to PD‐1 blockade, presenting a promising
Wenfeng Zhuo   +14 more
wiley   +1 more source

Wh-ex-situ in Mandarin Chinese: Mapping Between Information Structure and Split CP

open access: yes, 2014
International audienceThis paper examines the so-called wh-ex-situ phenomenon in Mandarin Chinese. It shows that there are four different types of wh-ex-situ in the left-periphery of Mandarin: Type I: extracted wh-topic, Type II: extracted wh-focus, Type
Pan, Victor Junnan
core  

Junction Physics and Architectural Paradigms in Optoelectronic Semiconductor Fibers

open access: yesAdvanced Science, EarlyView.
Optoelectronic fibers are emerging as a key platform for distributed sensing, energy harvesting, and optical communication in deformable systems. Their performance is fundamentally governed by junction formation under confined, dynamic processing conditions.
Hailiang Wang   +4 more
wiley   +1 more source

Wortstellungsalternation in wh-in-situ-Interrogativsätzen des Französischen und brasilianischen Portugiesischen : Eine experimentelle Studie.

open access: yes
Die vorliegende Dissertation untersucht die Wortstellungsalternation in wh-in-situ-Interrogativsätzen des Französischen und des brasilianischen Portugiesischen (BP).
Kaiser, Katharina
core  

Adaptive Coordination Engineering for Efficient and Robust H2 Release

open access: yesAdvanced Science, EarlyView.
β‐H elimination is a pivotal but challenging step in homogeneous formic acid dehydrogenation reactions due to strict hydride‐metal matching. By using a rationally designed Pd1Ag2 bimetallic system with adaptive Pd1‐Ag2/L2 coordination and formate bridges, it enables boosted formic acid dehydrogenation under ambient air (7.7 times higher than a Pd ...
Xiaolin Jiang   +8 more
wiley   +1 more source

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