Results 151 to 160 of about 20,590 (288)

Alkaline Phosphatase‐Activated NIR‐II AIEgens Nanosystem for Surgical and Postoperative Closed‐Loop Therapy of Advanced Osteosarcoma

open access: yesAdvanced Science, EarlyView.
This study designed a tumor microenvironment‐responsive AIEgen nanoparticle for near‐infrared photoimmunotherapy, which inhibits primary tumors and metastasis by promoting pyroptosis and suppressing aerobic glycolysis. ABSTRACT In advanced osteosarcoma, tumor invasion often prevents complete resection, and immunotherapy is limited by the tumor's ...
Kaiyuan Liu   +14 more
wiley   +1 more source

Connexin43 Deficiency Leads to Ventricular Arrhythmias by Reprogramming Proline Metabolism

open access: yesAdvanced Science, EarlyView.
The study demonstrated that connexin43 (Cx43) knockout caused arrhythmic phenotype and decreased proline content in vitro and in vivo. Mechanistically, Cx43 interacts with the amino acid transporter SNAT2 (sodium‐dependent neutral amino acid transporter), and its deficiency disrupts proline transport and metabolism.
Hangying Ying   +8 more
wiley   +1 more source

Valence‐Engineering of CeO2 Redox Modulator Boosts the Oxygen Electrocatalysis Performance in Fe/Co Dual‐Atom Catalyst

open access: yesAdvanced Science, EarlyView.
Valence‐engineering of CeO2 redox modulator can remove the highly oxidative by‐products and accelerate the oxidation state transitions of Co/Fe centers in FeCo dual‐atom catalyst during oxygen reduction/evolution electrocatalysis. Therefore, the stability and activity issues are resolved, significantly enhancing the overall performance when used as an ...
Hengqi Liu   +10 more
wiley   +1 more source

Single‐Cell Atlas of Subchondral Bone Marrow Lesions Reveals Proteostasis Dysfunction as a Druggable Mechanism for Early Osteoarthritis

open access: yesAdvanced Science, EarlyView.
This study reveals that abnormal mechanical stress downregulates the expression of HSP70 and impairs proteasome function in osteoarthritic bone cells, leading to misfolded collagen I accumulation and ER stress. When intracellular proteostasis capacity is exceeded, USP19 mediates the secretion of misfolded proteins into the extracellular space ...
Hailun Xu   +20 more
wiley   +1 more source

Multi‐Soliton Microcombs Enable Ultrafast Nanometric‐Precision Ranging and Photon‐Level Detection

open access: yesAdvanced Science, EarlyView.
Our work first demonstrates dual‐multi‐soliton ranging and confirms its multifunctional capability. The method achieves ultrafast and nanometric‐precision measurement. For practical applications, we further extend the multi‐soliton states to photon‐level ranging.
Jiawen Zhi   +10 more
wiley   +1 more source

Tailoring Sieving Pores and Electrochemical Interface Intercalation for Mechanically Resilient Recycled Micro‐Silicon Anodes

open access: yesAdvanced Science, EarlyView.
Here, an innovative strategy is proposed, using micron‐sized Si recovered from photovoltaic waste as raw material, combined with electrochemical lithium alloying, reacting with CO2 to obtain sieve‐like porous structure design to overcome mechanical dynamic limitations.
Yunan Wei   +4 more
wiley   +1 more source

Home - About - Disclaimer - Privacy