Results 31 to 40 of about 860,744 (306)

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Numerical simulation on 90° impact test of aluminium alloy wheel with the effect of tyre

Scientific Reports
Car wheels are crucial to automobile safety, requiring a rigorous test before production. A 90° impact test simulates the frontal impact and its influences on the wheel structure, replicating dynamic driving conditions.
Guangdong Zhang, Shike Tao, Yangyang Zhou, Jianjun Lu, Risheng Li, Shihui Li, Linzhen Zhou, Tong Deng   +7 more
doaj   +1 more source

Haversian canal structures can be associated with size effects in cortical bone [PDF]

, 2012
Prediction of periprosthetic failure may be improved by an improved model of bone elasticity which includes microstructural information. Micropolar theory facilitates such information to be included in a continuum model.
Frame, Jamie Campbell, Riches, Philip, Wheel, Marcus   +2 more
core  

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

FEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani, Eiman Y. Ibrahim, Rozalyn L. Rodwin, Leah M. Ferrucci, Kim Blenman, Maryam Lustberg, Barbara E. Ehrlich   +6 more
wiley   +1 more source

Investigation of tractor engine power and economical working conditions utilization during transport operation [PDF]

Transport, 2008
Article analyzes tractor working and its engine conditions from economical point of view. Overview of tractor wheel slippage reliance on the traction force and weight utilization coefficient is given.
Antanas Juostas, Algirdas Janulevičius
doaj   +1 more source

Experiments with a Malkus-Lorenz water wheel: Chaos and Synchronization

, 2012
We describe a simple experimental implementation of the Malkus-Lorenz water wheel. We demonstrate that both chaotic and periodic behavior is found as wheel parameters are changed in agreement with predictions from the Lorenz model.
Abarbanel H. D. I., Abarbanel H. D. I., Alison M. Saunders, Golub G. H., Kantz H., Lucas Illing, Malkus W. V. R., Oseledets V. I., Pikovsky A., Rachel F. Fordyce, Robert Ormond, Strogatz S. H.   +11 more
core   +1 more source

Multidimensional Profiling of MRI‐Negative Temporal Lobe Epilepsy Uncovers Distinct Phenotypes

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Although hippocampal sclerosis (TLE‐HS) represents the most frequent cause of temporal lobe epilepsy (TLE), up to 30% of patients show no lesion on visual MRI inspection (TLE‐MRIneg). These cases pose diagnostic and therapeutic challenges and are underrepresented in surgical series.
Alice Ballerini, Alessia Casarini, Niccolò Biagioli, Laura Mirandola, Daniela Ballotta, Paul Summers, Simona Scolastico, Laura Madrassi, Maurilio Genovese, Marcella Malagoli, Gaetano Cantalupo, Giada Giovannini, Matteo Pugnaghi, Niccolò Orlandi, Laura Tassi, Valeria Cuccarini, Domenico Aquino, Elena Tartara, Fulvia Palesi, Giuseppe Didato, Paolo Vitali, the 3TLE Study Group, Roberta Di Giacomo, Fabio Doniselli, Federica Mazzi, Carlo Andrea Galimberti, Claudia A. M. Gandini Wheeler‐Kingshott, Stefano Meletti, Anna Elisabetta Vaudano   +28 more
wiley   +1 more source

Unified Hydraulic System of Automatic Control and Life Support for the Family Prospective Hydromechanical Transmission MWTP

Механика машин, механизмов и материалов, 2011
In the paper considered the schematic circuit, operating principle and arrangement of components assemblies and mechanisms unified hydraulic control system and life support for the family prospective hydromechanical transmission MWTP.
Yu.I. Nikolaev , S.N. Poddubko , A.A. Mackiewicz , S.G. Staskevich , Yu.E. Pavlov   +4 more
doaj  

Validation of a Genetic Risk Score Combined With Clinical Variables for Predicting Pulmonary Fibrosis in Early Rheumatoid Arthritis

Arthritis Care &Research, EarlyView.
Objective Pulmonary fibrosis (PF) is a severe extra‐articular manifestation of rheumatoid arthritis (RA). This study aimed to externally validate a genetic risk score (GRS) and a combined risk score (CRS) for predicting the risk of RA‐associated PF in an independent cohort of patients with early RA.
Mikael Brink, Austin Wheeler, Bryant R. England, Solbritt Rantapää‐Dahlqvist   +3 more
wiley   +1 more source

Analysis of wheel and rail Hertzian and Non-Hertzian contact theories using UM software considering the effect of rail inclination on wheel wear [PDF]

International Journal of Railway Research, 2021
Wheel-rail interaction has always been one of the issues in the railway industry. In this paper, the effect of Hertzian and non-Hertzian contact theories on the wheel wear due to the rail inclination was investigated. by using the UM software.
M. Aziznia, A. Owhadi, M. Shadfar
doaj