Results 61 to 70 of about 101,423 (307)

PD‐1 Inhibits CD4+ TRM‐Mediated cDC1 Mobilization via Suppressing JAML in Human NSCLC

Advanced Science, EarlyView.
CD4+ tissue‐resident memory T cells (TRMs) in non‐small cell lung cancer recruit conventional type 1 dendritic cells via XCL1‐XCR1 signaling, orchestrating antitumor immunity. The costimulatory molecule JAML is essential for this process. PD‐1 blockade restores JAML expression and cDC1 mobilization, while JAML agonists synergize with anti‐PD‐1 therapy,
Zheyu Shao, Qinyuan Liu, Zhongwei Xin, Zhiyao Zhou, Mingjie Lin, Di Chen, Zhixing Hao, Yongyuan Chen, Wenxuan Wu, Shuyang Zhang, Xiaoke Chen, Xia Xu, Jinfan Li, Wei Lin, Yuhao Lu, Dang Wu, Pin Wu   +16 more
wiley   +1 more source

Risk factors for early wheezing in preterm infants: a retrospective cohort study

Frontiers in Pediatrics
IntroductionThe related factors that cause recurrent wheezing in children are complex, and premature delivery may be one of the reasons. Little is known about early wheezing in preterm infants.MethodsData sourced from 1,616 children born between 2007 and
Xun Chen, Minjing Yang, Jun Xie, Shengzhu Huang, Xiaolian Qin, Zhijian Pan, Maoling Zhu, Dingyuan Zeng, Yifeng Huang, Tao Liang, Chunmei Liang, Guangmin Nong   +11 more
doaj   +1 more source

Surveys on the Prevalence of Pediatric Bronchial Asthma in Japan: A Comparison between the 1982, 1992, and 2002 Surveys Conducted in the Same Region Using the Same Methodology

Allergology International, 2009
Background: We conducted and reported the first (1982; 55,388 subjects), and second (1992; 45,674 subjects), epidemiological surveys conducted on bronchial asthma in elementary students across 11 prefectures in western Japan. The 2 surveys were conducted
Sankei Nishima, Haruo Chisaka, Takashi Fujiwara, Kenshi Furusho, Shigefumi Hayashi, Kazumi Hiraba, Masaaki Kanaya, Nobuo Kobayashi, Naoki Kuda, Toshinori Kumamoto, Toshinari Maeda, Akira Murayama, Yoshitaka Nagata, Hiroshi Narukami, Kiyoshi Nishikawa, Ken Nishio, Hiroshi Odajima, Shoki Oka, Takahiro Okabe, Kaoru Okazaki, Toyoharu Okazaki, Minoru Okuma, Kunitaka Ota, Kimiyoshi Satomi, Masahiko Shimomura, Masatomo Suda, Isao Sunagawa, Osamu Tanaka   +27 more
doaj   +1 more source

A swimmer’s wheeze [PDF]

CJEM, 2006
A previously healthy 38-year-old triathlete prepared for a swim in a cold (15°C) lake by drinking 1/2 L of a protein supplement and putting on a wetsuit. After swimming approximately 500 m, she developed dyspnea. She stopped momentarily and then continued on, but developed further dyspnea associated with chest constriction and wheezing.
Brian, Deady, James, Glezo, Stephen, Blackie   +2 more
openaire   +2 more sources

It’s scary, scary, scary …”: the lived experience of asthma. [PDF]

, 2015
The research presented here contributes to a developing sociological-phenomenological empirical corpus of literature by addressing the lived experience of asthma in non-élite sports participants and committed exercisers.
Allen-Collinson, Jacquelyn, Owton, Helen, Siriwardena, Aloysius Niroshan   +2 more
core  

Health Effects Associated With Electronic Cigarette Use: Automated Mining of Online Forums. [PDF]

, 2020
BACKGROUND:Our previous infodemiological study was performed by manually mining health-effect data associated with electronic cigarettes (ECs) from online forums.
Hristidis, Vagelis, Hua, My, Sadah, Shouq, Talbot, Prue   +3 more
core  

Single‐Cell RNA Sequencing of Human Lung Tissues Reveals Metallothionein‐Positive T Cells as a Novel Potential Marker of Susceptibility to Chronic Obstructive Pulmonary Disease

Advanced Science, EarlyView.
Using single‐cell RNA sequencing of lung samples and flow cytometry of peripheral blood, we identified a novel T cell subset with high metallothionein (MT) expression. These MT‐high T cells suppress CD8+ T cell cytotoxicity and are progressively depleted from healthy controls to chronic obstructive pulmonary disease (COPD) patients, positioning them as
Zengqing Liu, Xiaoxia Ren, Mi Mu, Huanyu Long, Jialu Lv, Zhihong Feng, Jie Liu, Jiajia Wang, Hui Deng, Fanyu Shi, Muzhi Zhang, Ruoyang Zhang, Yang Liu, Mengyu Xu, Yang Fan, Zengtao Wang, Zhe Lv, Yan Chen, Chris J. Corrigan, Ying Sun, Yahong Chen, Chen Chen, Ye Cui, Wei Wang   +23 more
wiley   +1 more source

Lung functions and IgE component sensitizations: Five wheezing phenotypes in adolescents from the T-Child study in Tokyo

Journal of Allergy and Clinical Immunology: Global
Background: The endophenotypes of allergic disorders are known to vary across racial groups, underscoring the importance of studying allergic disease phenotypes in the population of Tokyo.
Kiwako Yamamoto-Hanada, MD, PhD, Limin Yang, MD, PhD, Mayako Saito-Abe, MD, PhD, Fumi Ishikawa, MD, Miori Sato, MD, Yumiko Miyaji, MD, PhD, Motoko Mitsui-Iwama, MD, PhD, Yusuke Inazuka, MD, PhD, Koji Nishimura, MD, Kenji Toyokuni, MD, PhD, Hiroya Ogita, MD, Tomoyuki Kiguchi, MD, Yoshitsune Miyagi, MD, Shinichiro Inagaki, MD, PhD, Shigenori Kabashima, MD, PhD, Tatsuki Fukuie, MD, PhD, Masami Narita, MD, PhD, Elizabeth Huiwen Tham, MBBS, MRCPCH, Mmed (Paed), Yukihiro Ohya, MD, PhD   +18 more
doaj   +1 more source

High‐Fidelity Synthetic Data Replicates Clinical Prediction Performance in a Million‐Patient Diabetes Cohort

Advanced Science, EarlyView.
This study generates high‐fidelity synthetic longitudinal records for a million‐patient diabetes cohort, successfully replicating clinical predictive performance. However, deeper analysis reveals algorithmic biases and trajectory inconsistencies that escape standard quality metrics. These findings challenge current validation norms, demonstrating why a
Francisco Ortuño, Víctor M. de la Oliva Roque, Javier‐Ignacio Ramirez‐Lopez, David P. Kreil, Joaquín Dopazo, Carlos Loucera   +5 more
wiley   +1 more source

Survey of respiratory sounds in infants [PDF]

, 2001
Background: Over the last decade there has been an apparent increase in childhood wheeze. We speculated that much of the reported increase may be attributed to the term wheeze being adopted by parents to describe a variety of other forms of noisy ...
Elphick, H.E., Everard, M.L., Foxall, G., Primhak, R.A., Sherlock, P., Shiell, N.A., Simpson, E.J.   +6 more
core   +2 more sources