Results 91 to 100 of about 11,832,712 (294)

MARK4 enhances stress granule formation under oxidative stress and increases tau accumulation

FEBS Open Bio, EarlyView.
MARK4 (red dots) localizes to stress granules (orange dots) and promotes their formation under oxidative stress by modulating TIA1 (blue dots). MARK4 and TIA1 synergistically increase tau (purple) accumulation, and the reduction of the TIA1 ortholog suppresses neurodegeneration in a fly model.
Sho Nakajima, Kotone Watanabe, Grigorii Sultanakhmetov, Aoi Fukuchi, Keiya Ito, Sawako Shimizu, Taro Saito, Akiko Asada, Kanae Ando   +8 more
wiley   +1 more source

ARF-GAP-mediated interaction between the ER-Golgi v-SNAREs and the COPI coat [PDF]

, 2002
In eukaryotic cells, secretion is achieved by vesicular transport. Fusion of such vesicles with the correct target compartment relies on SNARE proteins on both vesicle (v-SNARE) and the target membranes (t-SNARE).
Rein, U., Rein, Ulrike, Anne Spang, Spang, Anne, Hans Dieter Schmitt, Andag, Uwe, Ulrike Rein, Duden, R., Schmitt, Hans Dieter, Duden, Rainer, Spang, A., Andag, U., Uwe Andag, Schmitt, H. D., Rainer Duden, Schmitt, H.   +15 more
core   +1 more source

The Effect of a High Thermal Gradient on Sintering and Stiffening in the Top Coat of a Thermal Barrier Coating (TBC) System

, 2003
Superalloy substrates coated with plasma sprayed CoNiCrAlY bond coats and yttria-stabilized zirconia top coats have been subjected to a high heat flux in a controlled atmosphere chamber.
Tsipas, S.A., Clyne, T.W., Golosnoy, I.O.   +2 more
core   +1 more source

Genome-wide association study of white-coat effect in hypertensive patients

Blood Pressure, 2019
Background: White-coat effect (WCE) confounds diagnosis and treatment of hypertension. The prevalence of white-coat hypertension is higher in Europe and Asia compared to other continents suggesting that genetic factors could play a role.
Jenni M Rimpelä, Teemu Niiranen, Antti Jula, Ilkka H Pörsti, Antti Tikkakoski, Aki Havulinna, Terho Lehtimäki, Veikko Salomaa, Kimmo K Kontula, Timo P Hiltunen   +9 more
doaj   +1 more source

Magnitude of the Difference Between Clinic and Ambulatory Blood Pressures and Risk of Adverse Outcomes in Patients With Chronic Kidney Disease

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2019
Background Obtaining 24‐hour ambulatory blood pressure (BP) is recommended for the detection of masked or white‐coat hypertension. Our objective was to determine whether the magnitude of the difference between ambulatory and clinic BPs has prognostic ...
Elaine Ku, Raymond K. Hsu, Delphine S. Tuot, Se Ri Bae, Michael S. Lipkowitz, Miroslaw J. Smogorzewski, Barbara A. Grimes, Matthew R. Weir   +7 more
doaj   +1 more source

White Coat Effect: Is It Because of the Hospital Setting, or Is It Physician-Induced? [PDF]

Cureus, 2023
Singh M, Singh N, Pahuja H, Arora R, Anshul, Patel H.   +5 more
europepmc   +1 more source

Evaluating GenAI‐produced feedback on undergraduate bioscience essays against good higher education feedback practice

FEBS Open Bio, EarlyView.
This pilot study investigates the potential of Generative AI to provide formative feedback to students. ChatGPT was prompted to provide feedback on Year 1 Bioscience essays, which were evaluated against established good feedback practices. GenAI‐authored feedback had useful elements, but was limited in scope. GenAI may have potential to provide instant,
Annabel Court, Nigel Francis, Andrew Shore, Stephen Rutherford   +3 more
wiley   +1 more source

White Coat Ceremony as a Professional Identity Formation Activity in a United States Family Medicine Residency Program

, 2016
Introduction White coat ceremonies (WCCs) in medical school mark the transition of students to medicine, beginning their professional identity formation as a physician.
Jacob Lee Bidwell, de Grandville, Catherine, Santana, Esmeralda, Bidwell, Jacob Lee, Esmeralda Santana, Deborah Simpson, Catherine de Grandville, Mark W. Robinson, Simpson, Deborah, Robinson, Mark W   +9 more
core   +1 more source

Selective elimination of quiescent cancer cells by dequalinium chloride via ROS‐mediated ferroptosis

FEBS Open Bio, EarlyView.
Dequalinium chloride (DQ) selectively eliminates quiescent cancer cells (QCCs) by amplifying mitochondrial ROS. QCCs exhibit elevated basal ROS and limited redox‐buffering capacity, making them vulnerable to further ROS increases. DQ‐induced ROS exceeds the tolerance threshold, triggering lipid peroxidation and ferroptosis, whereas proliferating cells ...
Kotaro Miyamoto, Shiori Sakai, Minori Endo, Terigele, Mizuho Niibori, Taiki Morita, Yu Goto, Arisa Yoshida, Tomohiro Tanaka, Ning Lin, Takahiro Kuchimaru, Hiroyuki Nakamura, Masahiro Inoue, Shinae Kizaka‐Kondoh, Tetsuya Kadonosono   +14 more
wiley   +1 more source

Self‐Regulated Learning Meets AI: Reinterpreting Self‐Regulation, Co‐Regulation, and Socially Shared Regulation in Human–AI Interaction

New Directions for Adult and Continuing Education, EarlyView.
ABSTRACT Advancing artificial intelligence (AI) has transformed learning and work, yet higher education and professional development programs have not systematically equipped learners for AI‐prevalent environments. This lack of preparation creates uncertainty regarding control, responsibility, trust, and accountability.
Moon‐Heum Cho, Jerusalem Merkebu
wiley   +1 more source