Results 281 to 290 of about 257,277 (359)

White Adipose Tissue Browning and Cross Talk With Metabolic Diseases and Tumors: From Molecular Mechanisms to Clinical Translation

Med Research, EarlyView.
White adipose tissue undergoes browning under endogenous and exogenous stimuli, primarily regulated by core molecules such as PRDM16 and UCP1. It exhibits a double‐edged sword effect in metabolic diseases and tumors: while mitigating metabolic disease impacts and suppressing early‐stage tumors through nutritional competition, it may accelerate cachexia
Yingjiao Wang, Diyuan Zhang, Yuqin Zhou, Ling Qian, Yan Wang, Lei Peng, Min Zhao, Hao Tian, Zhenyu Wu, Aiqi Tang, Minghao Sun, Yi Zhang, Xiaowei Qi   +12 more
wiley   +1 more source

Osteoarthritis: An Immuno‐Inflammatory Disease‐Mechanisms of Immune Cell Dysregulation and Potential Therapeutic Strategies

Med Research, EarlyView.
This review summarizes the immuno‐inflammatory mechanisms driving the pathogenesis of osteoarthritis (OA), extending beyond the traditional view of OA as a purely degenerative disease to incorporate immune cell infiltration, inflammatory factor release, and the formation of a chronic low‐grade inflammatory microenvironment.
Qingqiang Lei, Xiaoxian Lou, Xu Su, Shubao Liu, Yanli Tong, Jie Chen, Xuerui Chen, Wenjun Mao, Hui Yu, Liangbin Lin   +9 more
wiley   +1 more source

White adipose tissue in type 2 diabetes and the effect of antidiabetic drugs. [PDF]

Diabetol Metab Syndr
Zhao Y, Yue R.
europepmc   +1 more source

Urologic Bacteriome: The Hero or the Villain in Prostate Cancer Onset, Progression, and Treatment?

Medicinal Research Reviews, EarlyView.
ABSTRACT Prostate cancer (PCa) is the second most frequently diagnosed cancer in men worldwide and the fifth leading cause of cancer‐related mortality, presenting urgent unmet clinical needs in diagnosis and treatment. The recognition of the microbiome as a key factor in human health has prompted numerous studies, revealing an exciting new approach to ...
Lara R. S. Fonseca, Mariana Feijó, Cátia V. Vaz, Bruno J. Pereira, Sandra Laurentino, Ana Palmeira‐de‐Oliveira, Sílvia Socorro   +6 more
wiley   +1 more source

The Long Noncoding RNA ΒFaar Promotes White Adipose Tissue Browning and Prevents Diet-Induced Obesity. [PDF]

Adv Sci (Weinh)
Yang Y, Huang B, Sha B, Gao D, Qin Y, Li Z, Chen X, Jin Y, Pan Y, Zhang Y, Shen Y, Liu Y, Jin L, Zhang F.   +13 more
europepmc   +1 more source

A Magnetic Resonance Fingerprinting Approach for Simultaneous T1$$ {T}_1 $$‐ and PRFS‐Based 3D MR‐Thermometry

Magnetic Resonance in Medicine, EarlyView.
ABSTRACT Purpose To evaluate a three dimensional dual echo magnetic resonance fingerprinting sequence for simultaneous proton resonance frequency shift (PRFS) and T1$$ {T}_1 $$ thermometry during microwave ablation with T1$$ {T}_1 $$ improving robustness near gas bubble induced susceptibility changes while PRFS provides high precision elsewhere ...
Moritz Gutt, Dominik Horstmann, Othmar Belker, Simon Schröer, Daniel Düx, Frank Wacker, Marcel Gutberlet, Bennet Hensen   +7 more
wiley   +1 more source

Microneedles-based local photothermal therapy promotes browning of white adipose tissue and combats obesity. [PDF]

Mater Today Bio
Li L, Chen H, Zhang K, Hu X, Xu M, Wen T, Ding J, Zhao M, Li Y, Su Y, Lin Z.   +10 more
europepmc   +1 more source

SelExNet: A Self‐Supervised Physics‐Informed Framework for Multi‐Channel Joint RF and Gradient Waveform Optimization in 2D Spatially Selective Excitation

Magnetic Resonance in Medicine, EarlyView.
ABSTRACT Purpose To introduce SelExNet: a self‐supervised framework for two‐dimensional spatially selective excitation that jointly optimizes radiofrequency (RF) pulses and gradient waveforms, and extends to multi‐channel transmission MRI. Methods Building on prior RF‐only and joint RF‐gradient optimization approaches, SelExNet couples neural RF and ...
Yuliang Xiao, Jason Rock, Zhe Wu, Jamie Near, Mark Chiew, Simon J. Graham   +5 more
wiley   +1 more source

White adipose tissue undergoes pathological dysfunction in the TDP-43^A315T mouse model of amyotrophic lateral sclerosis (ALS). [PDF]

Acta Neuropathol Commun
Benito-Casado C, Durán-Mateos E, Ferrer-Donato Á, García GB, Domínguez-Rubio R, Povedano M, Fernandez-Martos CM.   +6 more
europepmc   +1 more source

G Protein‐Coupled Receptor 17 (Gpr17) Enhances Leptin and Insulin Sensitivity in Lean and Obese Mouse Models

Obesity, EarlyView.
This study identifies G protein‐coupled receptor 17 (Gpr17) as a novel regulator of leptin and insulin sensitivity. Using complementary knockout models, we demonstrate that Gpr17 deletion enhances energy expenditure, restores leptin responsiveness, and improves insulin sensitivity, revealing Gpr17 as a potential therapeutic GPCR target for obesity and ...
Xun Sun, Connor Mahler, Natalie D. Stull, Ali Nasiri, Baohua Zhou, Varman Samuel, Gerald Shulman, Jonathan N. Flak, Hongxia Ren   +8 more
wiley   +1 more source