Results 301 to 310 of about 356,218 (360)

Utilization of Proteomic Measures for Early Detection of Drug Benefits and Adverse Effects

The Journal of Clinical Pharmacology, EarlyView.
Abstract Recognition of benefits and adverse effects of therapies in earlier clinical trial phases could improve the safety, efficiency, and cost of clinical trials. Using four clinical trials representing a diverse set of diseases and drug classes (EXSCEL: exenatide/GLP‐1 RA, SUGAR‐DM‐HF: empagliflozin/SGLT2i, PRADA: epirubicin/anthracycline, and ...
Jessica Chadwick, Colin Berry, Meredith A. Carpenter, Geeta Gulati, Siri Lagethon Heck, Michael A. Hinterberg, Rury R. Holman, Matthew M.Y. Lee, Torbjørn Omland, Clare Paterson, Mark C. Petrie, Naveed Sattar, Svati H. Shah, Sama Shrestha, Harald Sourij, Emma V Troth, Victoria Vinje, Stephen A. Williams   +17 more
wiley   +1 more source

Relationship between body mass index‐to‐thigh circumference ratio and incident hypertension among community‐dwelling persons

Journal of General and Family Medicine, EarlyView.
Receiver‐operating characteristics curve analysis to identify optimal BMI‐to‐thigh ratio to distinguish subjects with hypertension in the cross‐sectional and cohort data. Abstract Background The incidence of hypertension is increasing worldwide. Recent studies have suggested that smaller thighs are a disadvantage for health and survival, but the ...
Ryuichi Kawamoto, Kikuchi Asuka, Daisuke Ninomiya, Masanori Abe, Teru Kumagi   +4 more
wiley   +1 more source

Aging human abdominal subcutaneous white adipose tissue at single cell resolution. [PDF]

Aging Cell
Whytock KL, Divoux A, Sun Y, Pino MF, Yu G, Jin CA, Robino JJ, Plekhanov A, Varlamov O, Smith SR, Walsh MJ, Sparks LM.   +11 more
europepmc   +1 more source

Current Landscape of Short‐T2 Imaging Techniques in the Musculoskeletal System: The Past, Present and Future

Journal of Magnetic Resonance Imaging, EarlyView.
ABSTRACT Conventional MRI is limited in imaging tissues with short T2 relaxation times, such as bone, ligaments, and cartilage, due to their rapid signal decay. This limitation has spurred the development of specialized MRI techniques designed specifically for short‐T2 tissue imaging.
Pranjal Rai, Amit Kumar Janu, Nitin Shetty, Suyash Kulkarni   +3 more
wiley   +1 more source

Management of paediatric ulcerative colitis, part 1: Ambulatory care—An updated evidence‐based consensus guideline from the European Society of Paediatric Gastroenterology, Hepatology and Nutrition and the European Crohn's and Colitis Organisation

Journal of Pediatric Gastroenterology and Nutrition, EarlyView.
Abstract Objectives Despite advances in the management of ambulatory paediatric ulcerative colitis (UC), challenges remain as many patients are refractory to therapy and some require colectomy. The aim of these guidelines is to provide an update on optimal care for UC through detailed recommendations and practice points. Methods These guidelines are an
Eytan Wine, Marina Aloi, Stephanie Van Biervliet, Jiri Bronsky, Javier Martín di Carpi, Marco Gasparetto, Laura Gianolio, Hannah Gordon, Iva Hojsak, Alexandra S. Hudson, Séamus Hussey, Johan van Limbergen, Erasmo Miele, Lorenzo Norsa, Ola Olén, Gianluca Pellino, Patrick van Rheenen, Lissy de Ridder, Richard K. Russell, Dror S. Shouval, Eunice Trindade, Dan Turner, David C. Wilson, Anat Yerushalmy Feler, Amit Assa   +24 more
wiley   +1 more source

Noninvasive monitoring with bowel ultrasound (NIMBUS) in paediatric inflammatory bowel disease: Feasibility in a single centre

Journal of Pediatric Gastroenterology and Nutrition, EarlyView.
Abstract Objectives Bowel ultrasound (BUS) is increasingly utilised for monitoring inflammatory bowel disease (IBD), a condition with stringent treatment targets to prevent complications. This study assessed the feasibility of BUS in paediatric IBD and its correlation with established monitoring markers.
Zachary Green, Christopher Towriss, James J. Ashton, R. Mark Beattie, Alison Evans, Amar Wahid, Martin Edwards   +6 more
wiley   +1 more source

Hypothalamic SLC7A14 accounts for aging-reduced lipolysis in white adipose tissue of male mice. [PDF]

Nat Commun
Jiang X, Liu K, Luo P, Li Z, Xiao F, Jiang H, Wu S, Tang M, Yuan F, Li X, Shu Y, Peng B, Chen S, Ni S, Guo F.   +14 more
europepmc   +1 more source

Opuntia ficus‐indica fruit consumption improves insulin resistance in mice with diet‐induced obesity

Journal of the Science of Food and Agriculture, EarlyView.
Abstract BACKGROUND Obesity induces various co‐morbidities including insulin resistance. Opuntia ficus‐indica fruit (OFIF) is rich in various beneficial compounds with antioxidant and anti‐inflammatory properties. The present study evaluated the efficacy of OFIF supplementation to counteract obesity‐induced insulin resistance in comparison with an ...
Simona Terzo, Pasquale Calvi, Ignazio Restivo, Alessandro Massaro, Luisa Tesoriere, José‐Manuel Fernández‐Real, Marta Giardina, Antonella Amato, Flavia Mulè, Mario Allegra   +9 more
wiley   +1 more source

Deletion of NFIA Leads to Activation of S100A7 and Inflammatory Response‐Induced Apoptosis of Keratinocytes in Oral Lichen Planus Progression

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT S100 calcium‐binding protein A7 (S100A7) has been implicated in psoriasis and other inflammatory diseases. However, the function of S100A7 in oral lichen planus (OLP), a chronic inflammatory disease, remains unclear. OLP was induced in mice by transplanting human OLP lesions into the backs of thymus‐free mice, and an in vitro cell model was ...
Maimaiti Tudi, Zumulaiti Aierken, Maihebubaimu Tuerxun, Maimaitituxun Tuerdi   +3 more
wiley   +1 more source