Results 101 to 110 of about 9,704,035 (254)

Serum bilirubin is negatively associated with white blood cell count

Clinics
OBJECTIVE: Bilirubin is considered an important antioxidant, anti-inflammatory factor and immunomodulator. The current investigation aimed to explore the association between bilirubin and white blood cell (WBC) count in a large Chinese cohort.
Li Zhang, Chunmei Zhang, Zhaowei Meng, Lu Gong, Chongjie Pang, Xiangxiang Liu, Qing Zhang, Qiyu Jia, Kun Song   +8 more
doaj   +1 more source

Predictive Values of White Blood Cell Count in Peripheral Blood at Admission on In-Hospital Complications and 90-Day Outcomes of Patients with Aneurysmal Subarachnoid Hemorrhage: Insights from the LongTEAM Registry

Journal of Inflammation Research, 2022
Runting Li,1 Yuanli Zhao,1– 4 Xiaolin Chen,1,3,4 Qiang Hao1 1Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, People’s Republic of China; 2China National Clinical Research Center for Neurological Diseases ...
Li R, Zhao Y, Chen X, Hao Q
doaj  

Validation of a Cellular Imaging‐Based Method as a Potential Biomarker for SPG4 Hereditary Spastic Paraplegia

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Hereditary Spastic Paraplegia (HSP) comprises a group of rare genetic diseases characterized by length‐dependent axonal degeneration of the corticospinal tracts and dorsal columns, whose main clinical feature is spastic gait. Pathogenic variants in the SPG4 gene cause Spastic Paraplegia Type 4 (SPG4‐HSP), the most common form of HSP.
Gaia Fattorini, Valerio Licursi, Gianmarco Dalla Zanna, Flavio Dal Canto, Melissa Barghigiani, Nunzio Setola, Salvatore Rossi, Antonio Funcis, Filippo M. Santorelli, Gabriella Silvestri, Carlo Casali, Francesca Sardina, Cinzia Rinaldo   +12 more
wiley   +1 more source

Total White Blood Cell Count, Differential White Blood Cell Count and the Odds of Prostate Cancer

, 2015
Introduction The objective of this analysis was conducted to examine the association between total white blood cell (WBC) count, differential WBC count and the odds of prostate cancer (PCa) prevalence.
Erik Cook (797224)
core   +1 more source

Human red blood cells at work: identification and visualization of erythrocytic eNOS activity in health and disease [PDF]

, 2012
A nitric oxide synthase (NOS)-like activity has been demonstrated in human red blood cells (RBCs), but doubts about its functional significance, isoform identity and disease relevance remain.
Rodriguez-Mateos, Ana; id_orcid, Wolters, Dirk, Heiß, Christian, Rodriguez Mateos, Ana, Krenz, Thomas, Kuhnle, G. G. C., Cortese-Krott, Miriam M, Rodriguez-Mateos, Ana, Kelm, Malte, Cortese-Knott, Miriam M., Feelisch, Martin, Rodriguez-Mateos, Z, Kroncke, K.-D., Kröncke, Klaus-Dietrich, Sansone, R., Kuhnle, Gunter G. C., Kelm, M., Heiss, C., Krisp, C., Sansone, Roberto, Horn, P., Feelisch, M., Horn, Patrick, Krisp, Christoph, Krenz, T., Hogg, N., Kuhnle, Gunter, Kuhnle, Gunter G.C., Thasian-Sivarajah, S., Thasian-Sivarajah, Sivatharsini, Wolters, D., Cortese-Krott, Miriam M., Hogg, Neil, Cortese-Krott, M. M.   +33 more
core   +1 more source

White blood cell traits and lung cancer risk: a two-sample mendelian randomization analysis

Scientific Reports
This study aimed to investigate the potential association between white blood cell counts and the risk of lung cancer, including its subtypes, through Mendelian randomization (MR) analysis.
Kaijun Long, Zhengfeng Zhu, Xinzhe Zheng, Gang Xu, Cheng Chen, Xixian Ke   +5 more
doaj   +1 more source

Investigating the Analytical Variability and Agreement of Manual Leukocyte Quantification Methods in Eastern Box Turtles (Terrapene carolina carolina)

Frontiers in Veterinary Science, 2019
Leukogram evaluation provides valuable information about inflammation, infection, and stress in free-living and zoo-maintained wildlife. While multiple protocols for quantifying leukocytes are available in reptiles, agreement between methods is ...
John M. Winter, Nicole I. Stacy, Laura A. Adamovicz, Matthew C. Allender   +3 more
doaj   +1 more source

Intracerebral Hemorrhage Induces Monocyte TNF Signaling in Patients That Is Suppressed by BAF312

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Intracerebral hemorrhage (ICH) causes high morbidity and mortality, with neurotoxic inflammation driven by infiltrating monocytes. This study is an in‐depth longitudinal examination of the immune response during the first week of ICH in the presence and absence of the immunomodulatory drug BAF312 (Siponimod).
Jonathan Howard DeLong, Sebastian Díaz‐Pérez, Kevin Navin Sheth, Jang‐Ho Cha, C. J. Malanga, Patricia G. M. Wagner, Nicole Pezous, Aurelie Hanin, Kyle B. Walsh, H. E. Hinson, Lauren Hachmann Sansing   +10 more
wiley   +1 more source

CD4 cell count and the risk of AIDS or death in HIV-Infected adults on combination antiretroviral therapy with a suppressed viral load: a longitudinal cohort study from COHERE. [PDF]

, 2012
BACKGROUND: Most adults infected with HIV achieve viral suppression within a year of starting combination antiretroviral therapy (cART). It is important to understand the risk of AIDS events or death for patients with a suppressed viral load.
S. Matheron, M. Sharland, Niels Obel (135891), R. Thiebaut, Jesper Grarup (453101), José M Miro, Reiss, Peter, Furrer, H, D. Haerry, A. Cozzi Lepri, Josefa Muñoz (11702276), Miró Meda, José M. (José María), 1956-, Hansjakob Furrer (93994), Ole Kirk (314889), Gazzard, B, G. Touloumi, Raffi, F, Josefa Muñoz, J. Reekie, A. Castagna, G. Fatkenheuer, R. Lodwick, Niels Obel, Sophie Grabar (697347), S. Grabar, T. Goetghebuer, J. Grarup, The Opportunistic Infections Project Team of the Collaboration o (16174457), D. Gibb, A. Antinori, Peter Reiss (4933), E. Girardi, José M Miro (16174463), Raffi, Francois, Antonella Castagna (255402), Grarup, Jesper, F. Engsig, Peter Reiss, Kirk, Ole, F. Gutierrez, Opportunistic Infections Project Team of the Collaboration of Ob,, H. Furrer, J. Casabona, M. Egger, O. Lambotte, Sylvie Ayayi (16174460), J. Ghosn, V. Bouteloup, Obel, N, Young, Jim, De Wit, Stéphane, Chêne, Geneviève, Heiner Bucher, M. Psichogiou, Mina Psichogiou (146065), Y. Young, C. Stephan, Chêne, G, Martin Fisher (300134), C. Lewden, A. D’Arminio Monforte, Ayayi, Sylvie, R. Zangerle, Young, J, S. De Wit, Laurence Meyer (130347), Bucher, Heiner, Antonella Castagna, Miró, José María, Geneviève Chêne, C. Sabin, Meyer, Laurence, Félix Gutierrez, Miro, José M, P. Morlat, P. Tookey, C. Torti, Gazzard, Brian, R. Paredes, Miro, José M., The Opportunistic Infections Project Team of the Collaboration of Observational HIV Epidemiological Research in Europe (COHERE) in EuroCoord (614233), J. M. Miro, V. Le Moing, I. Weller, Francois Raffi, A. Mocroft, C. Smit, Jim Young (252690), S. Ayayi, Grarup, J, Jesper Kjaer, Sharland, M, Brian Gazzard, M. Prins, J. Warszawski, A. Noguera Julian, M. Garrido, De Wit, S, F. de Wolf, H. Bucher, Muñoz, J, J. Miro, C. Thorne, O. Kirk, Francois Raffi (6269708), Stéphane De Wit, Jesper Grarup, Gutierrez, Félix, J. Kjaer, Kjaer, J, J. Munoz, Bucher, Heiner H.C., Ole Kirk, V. von Wyl, C. Leport, A. Scherrer, L. Galli, Opportunistic Infections Project Team of the Collaboration of Observational HIV Epidemiological Research in Europe (COHERE) in EuroCoord, Kjaer, Jesper, D. Costagliola, J. Sterne, Sophie Grabar, Opportunistic Infections Project Team of the Collaboration of Ob, P. Reiss, F. Dabis, Heiner Bucher (3510056), Meyer, L, A. Antoniadou, Furrer, Hansjakob, Jim Young, J. Ramos, J. Bohlius, A. Phillips, Hansjakob Furrer, Noguera Julian, Antoni, Sylvie Ayayi, Collaboration of Observational HIV Epidemiological Research Europe (COHERE), Castagna, A, Geneviève Chêne (252698), Ayayi, S, Obel, Niels, C. Colin, Bucher, H, F. Raffi, R. Teira, Jesper Kjaer (453100), Castagna, Antonella, Psichogiou, M, L. Meyer, N. Brockmeyer, A. Rauch, G. Chene, Miro, JM, Grabar, Sophie, M. Puoti, Kirk, O, Laurence Meyer, Reekie, Joanne ; https://orcid.org/, Muñoz, Josefa, B. Gazzard, N. Obel, M. M. Krause, J. Del Amo, Mina Psichogiou, L. Wittkop, M. Battegay, Grabar, S, Stéphane De Wit (262489), Brian Gazzard (4921), M. Fisher, Reiss, P, Gutierrez, F, S. Perez Hoyos, M. Dorrucci, Mike Sharland (258810), M. Paulsen, B. Ledergerber, Mike Sharland, Sharland, Mike, Psichogiou, Mina, C. Mussini, Félix Gutierrez (379459), Miró Meda, José M., COHERE EuroCoord European AIDS Treatment Grp   +183 more
core   +2 more sources

Re‐Purposing Sapropterin (Kuvan) for ACTA2‐Related Multisystemic Smooth Muscle Dysfunction Syndrome: A Translational Mechanistic and First‐In‐Human Therapeutic Report

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Multisystemic smooth muscle dysfunction syndrome (MSMDS) is an ultra‐rare, ACTA2‐related disorder characterized by severe cerebrovascular disease, aortic aneurysms, and smooth muscle dysfunction. Using molecular dynamics simulations and in silico drug screening, we identified that sapropterin dihydrochloride (Kuvan) is a candidate capable of ...
Moran Hausman‐Kedem, Noa Bielopolski, Vijai Krishnan, Shane Wald‐Altman, Shelly I Shrian, Omer Bar‐Yosef, Livia Kapusta, Claire Shamber, Patricia L. Musolino, Miguel Weil   +9 more
wiley   +1 more source