Results 71 to 80 of about 2,453,662 (302)

Survivin and Aurora Kinase A control cell fate decisions during mitosis

Molecular Oncology, EarlyView.
Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir, Shalitha Wickrama Arachchige, Sally P. Wheatley   +2 more
wiley   +1 more source

White vs. colored coats: Which reduces dental anxiety better?

BMC Oral Health
Backgrounds To evaluate the effect of colored vs. white coat wear on dental anxiety in children using psychometric, projective, and physiological methods.
Elif Kilic, Sema Aydinoglu, Dilara Nil Gunacar   +2 more
doaj   +1 more source

The impact of hair coat color on longevity of Holstein cows in the tropics

Journal of Animal Science and Technology, 2016
Background Over two decades of observations in the field in South East Asia and Hawai‘i suggest that majority of the commercial dairy herds are of black hair coat.
C. N. Lee, K. S. Baek, A. Parkhurst
doaj   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Polymorphism of the Melanocortin 1 Receptor (MC1R) Gene and its Role in Determining the Coat Colour of Central European Cattle Breeds

Animals, 2020
There are many genes responsible for the appearance of different coat colours, among which the melanocortin 1 receptor gene (MC1R) plays an important role. The aim of the study was to characterize genetic variation in Central European cattle breeds based
Karolina Kasprzak-Filipek, Wioletta Sawicka-Zugaj, Zygmunt Litwińczuk, Witold Chabuz, Rūta Šveistienė, Josef Bulla   +5 more
doaj   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Whole-Genome Resequencing Identifies KIT New Alleles That Affect Coat Color Phenotypes in Pigs

Frontiers in Genetics, 2019
The Duroc × (Landrace × Large White) hybrid pig (DLY) is the most popular commercial pig used in the Chinese pig industry. DLY pigs are usually white but sometimes show colored phenotypes. Colored DLY pigs are not favored by slaughterhouses and retailers,
Zhongping Wu, Zheng Deng, Min Huang, Yong Hou, Hui Zhang, Hao Chen, Jun Ren   +6 more
doaj   +1 more source

Strength through diversity: how cancers thrive when clones cooperate

Molecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken, Maartje Witsen, Emile E. Voest, Krijn K. Dijkstra   +3 more
wiley   +1 more source

Genetic, historical and breeding aspects of the occurrence of the tobiano pattern and white markings in the Polish population of Hucul horses – a review

Journal of Applied Animal Research, 2020
In recent years, different patterns of piebald/skewbald coat colour have become popular in horses. The tobiano pattern may appear in one of three forms: minimal, classic or maximal.
Marta Pasternak, Jędrzej Krupiński, Artur Gurgul, Monika Bugno-Poniewierska   +3 more
doaj   +1 more source

Identification of a Missense Variant in MFSD12 Involved in Dilution of Phaeomelanin Leading to White or Cream Coat Color in Dogs

Genes, 2019
White coat color in mammals has been selected several times during the domestication process. Numerous dog breeds are fixed for one form of white coat color that involves darkly pigmented skin.
B. Hédan, É. Cadieu, Nadine Botherel, C. Dufaure de Citres, A. Letko, M. Rimbault, C. Drögemüller, V. Jagannathan, T. Derrien, S. Schmutz, T. Leeb, C. André   +11 more
semanticscholar   +1 more source