Results 101 to 110 of about 76,033 (333)

Folic Acid‐Modified Ginger‐Derived Exosome‐Like Nanoparticles Co‐Delivering Sunitinib Suppress Renal Cell Carcinoma via PI3K‐Akt Pathway Inhibition, P‐gp Downregulation, and Macrophage Reprogramming

Advanced Science, EarlyView.
FPD‐GELNs co‐deliver Su and bioactive components. This active‐passive dual‐targeting strategy suppresses the progression of RCC through the following mechanisms: 1) inhibition of the PI3K‐Akt signaling pathway; 2) downregulation of ABCB1/P‐gp to enhance the chemosensitivity of RCC to Su; and 3) reprogramming of macrophages toward M1 polarization and ...
Haoyu Xu, Daixing Hu, Shixue Liu, Lei Yang, Junwu Li, Yuanyuan Bai, Guozhi Zhao, Wei Tang, Li Jiang   +8 more
wiley   +1 more source

The use of automated sequential blood pressure in hypertension clinics compared with office and ambulatory blood pressure measurements

The Egyptian Heart Journal, 2020
Background Office blood pressure (OBP) measurement is the most common method of blood pressure measurement. However, it is associated with several pitfalls as white coat effect and masked hypertension.
Kareem Mahmoud, Ayah ElAroussy, Yasser Baghdady, Wafaa ElAroussy, Heba ElDeeb   +4 more
doaj   +1 more source

The Utility of Ambulatory Blood Pressure Monitoring for Diagnosing White Coat Hypertension in Older Adults [PDF]

, 2015
The beneficial effect of antihypertensive medication on reducing the risk of cardiovascular disease (CVD) events is supported by data from randomized controlled trials of older adults with hypertension.
Bowling, C. Barrett, Harrison, Teresa N., Reynolds, Kristi, Shimbo, Daichi, Sim, John J., Sridharan, Lakshmi   +5 more
core   +2 more sources

Pulmonary‐Targeted Nanoparticles Interrupt the Malignant Mechanical and Biochemical Signaling Crosstalk for Idiopathic Pulmonary Fibrosis Therapy

Advanced Science, EarlyView.
Idiopathic pulmonary fibrosis (IPF) progression is driven by TGF‐β induced biochemical signals and mechanical signals from increased ECM stiffness. Pulmonary‐targeted VB‐RT NPs not only eliminate excessive ROS and penetrate the dense ECM collagen barrier via NO release, but also simultaneously interrupt the persistent malignant between mechanical and ...
Xue‐Na Li, Ya‐Ping Lin, Xi‐Xi Ma, Yue‐Fei Fang, Hui Wang, Chun‐Hui Cui, Chen Zhang, Jin‐You Piao, Jee‐Heon Jeong, Xian Wu Cheng, Lei Xing, Hu‐Lin Jiang   +11 more
wiley   +1 more source

Alpinetin Nanoparticles Alleviate Optic Nerve Injury Induced by Acute Glaucoma via LRP1‐PPARγ Mediated Regulation of Microglial Lipid Metabolism

Advanced Science, EarlyView.
Microglial lipid metabolic dysfunction drives neurodegeneration in glaucoma. We found loss of LRP1 causes lipid accumulation and inflammation. We developed alpinetin‐loaded nanoparticles (AlpNPs) that bind LRP1, activate the PPARγ‐LXRα‐ABCA1 pathway to restore lipid homeostasis, promote an anti‐inflammatory phenotype, and protect retinal ganglion cells,
Miao Wei, Yujia Huo, Jingchang Yuan, Xiao Fan, Xiaochen Wang, Sisi Tan, Xi Gao, Ruotong Ouyang, Hong Li   +8 more
wiley   +1 more source

Hipertensión y efecto de bata blanca. The high blood pressure and the white coat effect. [PDF]

Revista Cubana de Cardiología y Cirugía Cardiovascular, 2010
La hipertensión de bata blanca (HTABB) es aquella en que la presión arterial en el consultorio o en el hospital, es mayor que fuera de ellos. Es una variable discreta (todo o nada), que tiene el riesgo de que se catalogue a una persona normal como ...
David García Barreto, Ernesto Groning Roque, Raymid García Fernández, Alberto Hernández Cañero   +3 more
doaj  

Prevalence and Clinical Characteristics of Refractory Hypertension

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2017
BackgroundWe aimed to estimate the prevalence of refractory hypertension (RfH) and to determine the clinical differences between these patients and resistant hypertensives (RH).
Pedro Armario, David A. Calhoun, Anna Oliveras, Pedro Blanch, Ernest Vinyoles, Jose R. Banegas, Manuel Gorostidi, Julián Segura, Luis M. Ruilope, Tanja Dudenbostel, Alejandro de la Sierra   +10 more
doaj   +1 more source

Maladaptive rumination moderates the effects of written emotional disclosure on ambulatory blood pressure levels in females. [PDF]

, 2014
Written emotional disclosure (WED) has beneficial effects on health outcomes. However, its effectiveness is influenced by a number of variables. This exploratory study tested whether trait rumination, which comprises brooding, a maladaptive component ...
Ashley, L, Ferguson, E, Jones, F, O'Connor, DB   +3 more
core   +2 more sources

Smart Semiconductors: An Overview of AZnOS (A= Ca, Sr, Ba) Based Phosphors, Multi‐Stimuli Responsive Luminescence, and Potential Application Prospects

Advanced Science, EarlyView.
This paper reviews the research progress of CaZnOS, SrZnOS, and BaZnOS‐based semiconductor phosphors in recent years, including their crystal structures, synthesis methods, and luminescent properties, as well as summarizes their potential applications. Finally, the challenges and opportunities for the research of these phosphors are also summarized and
Yanze Wang, Xianhui Zhang, Biyun Ren, Jingnan Zhang, Qi'an Zhang, Ziyi Fang, Mingzhi Wu, Leipeng Li, Yanmin Yang, Yixi Zhuang, Gongxun Bai, Jiulin Gan, Dengfeng Peng   +12 more
wiley   +1 more source

Cortical Microvascular Pulsatility in the Aging Mouse Brain and the Confounding Effects of Anesthesia

Advanced Science, EarlyView.
Multi‐modal optical imaging reveals microvascular pulsatility in the brain cortex of awake and anaesthetized mice. Awake hemodynamics in male mice are found to be remarkably stable until late life, with flow pulsatility being significantly higher than in females, despite similar average perfusion.
Mia Viuf Skøtt, Elizaveta Melnikova, Eugenio Gutiérrez, Vladimir Matchkov, Leif Østergaard, Dmitry D Postnov   +5 more
wiley   +1 more source