Results 101 to 110 of about 33,363 (299)

Migrasomes in Ischemic Stroke: Molecular Landscape and Pathophysiological Impact

Advanced Science, EarlyView.
Multi‐omics profiling of stroke patients exposes systemic molecular fingerprints of immune activation, oxidative stress and metabolic collapse. Complement and coagulation cascade, and cholesterol metabolism emerge as shared functional hallmarks of plasma migrasomes in stroke patients and migrasomes isolated from experimental stroke mice.
Huifen Zhou, Yingying Zhang, Peng Zhou, Haofang Wan, Lingling Li, Bin Xu, Yuping Wan, Yingming Song, Yi Kang, Hongbo Zhang, Min Shi, Qun Hou, Jiehong Yang, Chen Ding, Wei Fu, Buchang Zhao, Haitong Wan   +16 more
wiley   +1 more source

Cholesterol Promotes Lung Adenocarcinoma Brain Metastasis by Stabilizing EGFR Protein to Drive EMT, Metabolic Reprogramming, and Premetastatic Niche Formation

Advanced Science, EarlyView.
Cholesterol is revealed as a multitasking fuel for lung adenocarcinoma brain metastasis: it locks EGFR at the membrane to sustain AKT/NF‐κB–driven glycolysis and EMT, loosens the blood–brain barrier by promoting Claudin‐5 loss, and rewires microglia through IL‐4R lipid‐raft–JAK1/STAT6 signaling.
Ying Chen, Xiaoteng Cui, Xinyi Shi, Xu Yang, Yujing Cao, Haolin LI, Qi Zhan, Qixue Wang, Ang Li, Qihong Cheng, Yunfei Wang, Junhu Zhou, MingJie Wang, Chunsheng Kang, Xiaomin Liu   +14 more
wiley   +1 more source

Primary hypertension and special aspects of hypertension in older children and adolescents. [PDF]

, 2011
The prevalence of hypertension has increased at an accelerated rate in older children and adolescents. This has raised great concern about premature development of cardiovascular disease, which has major long-term health and financial implications. While
Ellis, Demetrius, Miyashita, Yosuke
core   +2 more sources

Two‐stage portal flow modulation for volume‐augmented grafts in living donor liver transplantation: Rat model validation

Animal Models and Experimental Medicine, EarlyView.
This study presents a two‐stage portal flow modulation strategy for graft procurement in living donor liver transplantation with the aim of expanding left lateral lobe grafts, thereby circumventing technical and anatomical limitations of conventional approaches.
Yuqi Gong, Yutong Chen, Zhoucheng Wang, Libin Dong, Zhengxing Lian, Kai Wang, Xiao Xu   +6 more
wiley   +1 more source

A prospective cohort study of home blood pressure monitoring based on an intelligent cloud platform (the HBPM-iCloud study): rationale and design

Therapeutic Advances in Chronic Disease, 2020
Background: Hypertension, as a predominant risk factor for cardiovascular disease, is a severe public health burden in China. Home blood pressure monitoring (HBPM) is an important tool in the detection and management of hypertension.
Hailan Zhu, Xiaoyan Liang, Xiong-Fei Pan, Chunyi Huang, Jian Kuang, Weibiao Lv, Qingchun Zeng, Weiyi Mai, Yuli Huang   +8 more
doaj   +1 more source

Inter-arm difference in systolic blood pressure in different ethnic groups and relationship to the "white coat effect" : a cross sectional study [PDF]

, 2017
Background Inter-arm differences (IAD) ≥10mmHg in systolic blood pressure (BP) are associated with greater incidence of cardiovascular disease. The effect of ethnicity and the white coat effect (WCE) on significant systolic inter-arm differences ...
Clark , C. E., Gill, Paramjit, Greenfield, S. M., Haque, M. S., Heer, G., Johal, Amanpreet, Kaur, R., Koshiaris, C., Mant, J., Martin, U., McManus, R. J., Mohammed, M. A., Schwartz , C. L., Wood, S.   +13 more
core   +5 more sources

Self-Measure Office Blood Pressure (SMOBP) and Home Blood Pressure Monitoring (HBPM) for white coat effect diagnosis among hypertension patients

, 2023
Pavornpath Burimsittichai, Tatree Bosittiphichet, Thanakamon Leesri   +2 more
openalex   +2 more sources

Comparative Safety Profiles of Ocrelizumab and Rituximab in Multiple Sclerosis Treatment Using Real‐World Evidence

Annals of Neurology, EarlyView.
Objective The objective of this study was to compare the long‐term safety profiles of ocrelizumab and rituximab in persons with multiple sclerosis (MS). Methods Using retrospective data from the University of California (UC) Health System, we simulated a target clinical trial. The primary cohort from UC San Francisco (UCSF) and a validation cohort from
Gabriel Cerono, Bruce A.C. Cree, Stephen L. Hauser, Sergio E. Baranzini   +3 more
wiley   +1 more source

Model for End‐Stage Liver Disease/Pediatric End‐Stage Liver Disease exception policy and outcomes in pediatric patients with hepatopulmonary syndrome requiring liver transplantation

Liver Transplantation, EarlyView., 2022
Abstract Hepatopulmonary syndrome (HPS) is associated with increased waitlist mortality in liver transplantation (LT) candidates. Children with HPS are granted Model for End‐Stage Liver Disease (MELD)/Pediatric End‐Stage Liver Disease (PELD) exception points for waitlist prioritization in the United States based on criterion developed for adults.
Muhammad H. Raza, Yong Kwon, Pierre Kobierski, Asish C. Misra, Angelina Lim, Cameron Goldbeck, Kambiz Etesami, Rohit Kohli, Juliet Emamaullee   +8 more
wiley   +1 more source

Blood pressure response to renal denervation is correlated with baseline blood pressure variability: a patient-level meta-analysis [PDF]

, 2018
Background: Sympathetic tone is one of the main determinants of blood pressure (BP) variability and treatment-resistant hypertension. The aim of our study was to assess changes in BP variability after renal denervation (RDN).
Berra, Elena, Blankestijn, Peter J., Bots, Michiel L., Burnier, Michel, Czarnecka, Danuta, de Jong, Mark R., Elvan, Arif, Fadl Elmula, Fadl Elmula M., Gordin, Daniel, Jacobs, Lotte, Kahan, Thomas, Kjeldsen, Sverre E., Mark, Patrick B., Miroslawska, Atena, Olszanecka, Agnieszka, Persu, Alexandre, Renkin, Jean, Rosa, Ján, Spaak, Jonas, Spiering, Wilko, Staessen, Jan A., Steigen, Terje K., Taylor, Alison H.M., the European Network COordinating research on Renal Denervation (ENCOReD), Thijs, Lutgarde, Tikkanen, Ilkka, Widimský, Jiří, Wuerzner, Gregoire   +27 more
core   +2 more sources