Results 101 to 110 of about 33,532 (321)

Cholesterol Promotes Lung Adenocarcinoma Brain Metastasis by Stabilizing EGFR Protein to Drive EMT, Metabolic Reprogramming, and Premetastatic Niche Formation

Advanced Science, EarlyView.
Cholesterol is revealed as a multitasking fuel for lung adenocarcinoma brain metastasis: it locks EGFR at the membrane to sustain AKT/NF‐κB–driven glycolysis and EMT, loosens the blood–brain barrier by promoting Claudin‐5 loss, and rewires microglia through IL‐4R lipid‐raft–JAK1/STAT6 signaling.
Ying Chen, Xiaoteng Cui, Xinyi Shi, Xu Yang, Yujing Cao, Haolin LI, Qi Zhan, Qixue Wang, Ang Li, Qihong Cheng, Yunfei Wang, Junhu Zhou, MingJie Wang, Chunsheng Kang, Xiaomin Liu   +14 more
wiley   +1 more source

Prevalence and Clinical Characteristics of Refractory Hypertension

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2017
BackgroundWe aimed to estimate the prevalence of refractory hypertension (RfH) and to determine the clinical differences between these patients and resistant hypertensives (RH).
Pedro Armario, David A. Calhoun, Anna Oliveras, Pedro Blanch, Ernest Vinyoles, Jose R. Banegas, Manuel Gorostidi, Julián Segura, Luis M. Ruilope, Tanja Dudenbostel, Alejandro de la Sierra   +10 more
doaj   +1 more source

Primary hypertension and special aspects of hypertension in older children and adolescents. [PDF]

, 2011
The prevalence of hypertension has increased at an accelerated rate in older children and adolescents. This has raised great concern about premature development of cardiovascular disease, which has major long-term health and financial implications. While
Ellis, Demetrius, Miyashita, Yosuke
core   +2 more sources

Two‐stage portal flow modulation for volume‐augmented grafts in living donor liver transplantation: Rat model validation

Animal Models and Experimental Medicine, EarlyView.
This study presents a two‐stage portal flow modulation strategy for graft procurement in living donor liver transplantation with the aim of expanding left lateral lobe grafts, thereby circumventing technical and anatomical limitations of conventional approaches.
Yuqi Gong, Yutong Chen, Zhoucheng Wang, Libin Dong, Zhengxing Lian, Kai Wang, Xiao Xu   +6 more
wiley   +1 more source

Inter-arm difference in systolic blood pressure in different ethnic groups and relationship to the "white coat effect" : a cross sectional study [PDF]

, 2017
Background Inter-arm differences (IAD) ≥10mmHg in systolic blood pressure (BP) are associated with greater incidence of cardiovascular disease. The effect of ethnicity and the white coat effect (WCE) on significant systolic inter-arm differences ...
Clark , C. E., Gill, Paramjit, Greenfield, S. M., Haque, M. S., Heer, G., Johal, Amanpreet, Kaur, R., Koshiaris, C., Mant, J., Martin, U., McManus, R. J., Mohammed, M. A., Schwartz , C. L., Wood, S.   +13 more
core   +5 more sources

Comparative Safety Profiles of Ocrelizumab and Rituximab in Multiple Sclerosis Treatment Using Real‐World Evidence

Annals of Neurology, EarlyView.
Objective The objective of this study was to compare the long‐term safety profiles of ocrelizumab and rituximab in persons with multiple sclerosis (MS). Methods Using retrospective data from the University of California (UC) Health System, we simulated a target clinical trial. The primary cohort from UC San Francisco (UCSF) and a validation cohort from
Gabriel Cerono, Bruce A.C. Cree, Stephen L. Hauser, Sergio E. Baranzini   +3 more
wiley   +1 more source

Urinary markers of renal damage in hypertensive children diagnosed with ambulatory blood pressure monitoring

The Turkish Journal of Pediatrics, 2014
Primary hypertension is the most important risk factor for chronic kidney disease in adulthood. However, the role of hypertension in kidney damage in childhood is not known exactly.
İlknur Girişgen, Ferah Sönmez, Ciğdem Yenisey, İmran Kurt-Omurlu   +3 more
doaj  

Automated Office Blood Pressure Measurements in Waiting Room or Isolated Room for Diagnosis and Phenotyping of Hypertension

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Automatic office blood pressure measurement (AOBPM) in the waiting room could improve the performance of diagnosing hypertension without requiring an isolated room to carry out exploration.
Marisol Sánchez Bacaicoa, Sergio Rico, Alejandra Gullón, Jacinto Fernandez Pardo, Juan Villa, Eva Nadiejda, Roberto Robles, Jose M. del Aguila, Pedro Cunha, Valentina Vassilenko, Enrique Rodilla, Juan F. Sánchez Muñoz‐Torrero   +11 more
doaj   +1 more source

Blood pressure response to renal denervation is correlated with baseline blood pressure variability: a patient-level meta-analysis [PDF]

, 2018
Background: Sympathetic tone is one of the main determinants of blood pressure (BP) variability and treatment-resistant hypertension. The aim of our study was to assess changes in BP variability after renal denervation (RDN).
Berra, Elena, Blankestijn, Peter J., Bots, Michiel L., Burnier, Michel, Czarnecka, Danuta, de Jong, Mark R., Elvan, Arif, Fadl Elmula, Fadl Elmula M., Gordin, Daniel, Jacobs, Lotte, Kahan, Thomas, Kjeldsen, Sverre E., Mark, Patrick B., Miroslawska, Atena, Olszanecka, Agnieszka, Persu, Alexandre, Renkin, Jean, Rosa, Ján, Spaak, Jonas, Spiering, Wilko, Staessen, Jan A., Steigen, Terje K., Taylor, Alison H.M., the European Network COordinating research on Renal Denervation (ENCOReD), Thijs, Lutgarde, Tikkanen, Ilkka, Widimský, Jiří, Wuerzner, Gregoire   +27 more
core   +2 more sources

Pro‐Inflammatory c‐Met+ CD4 T Cells in Multiple Sclerosis

Annals of Neurology, EarlyView.
Objective Hepatocyte growth factor (HGF) binds exclusively the c‐Met surface receptor, and the HGF/c‐Met axis regulates T cell function in autoimmune diseases. We analyzed c‐Met expression on human CD4 T cells in the blood and cerebrospinal fluid (CSF) from patients with multiple sclerosis (MS) versus non‐inflammatory neurological disease (NIND), to ...
Gautier Breville, Mahdia Benkhoucha, Ayman Rezk, Ngoc Lan Tran, Isis Senoner, Amit Bar‐Or, Patrice H. Lalive   +6 more
wiley   +1 more source