Results 51 to 60 of about 298,577 (257)

Diffusion basis spectrum imaging for identifying pathologies in MS subtypes [PDF]

, 2019
Diffusion basis spectrum imaging (DBSI) combines discrete anisotropic diffusion tensors and the spectrum of isotropic diffusion tensors to model the underlying multiple sclerosis (MS) pathologies. We used clinical MS subtypes as a surrogate of underlying
Cross, Anne H, George, Ajit, Naismith, Robert T, Perantie, Dana C, Schmidt, Robert E, Shirani, Afsaneh, Song, Sheng-Kwei, Sun, Peng, Trinkaus, Kathryn   +8 more
core   +2 more sources

White matter lesions and intra-arterial thrombolysis [PDF]

Journal of Neurology, 2012
The aim of the study was to assess the influence of white matter lesions in patients with acute ischemic stroke treated with intra-arterial thrombolysis (IAT). From September 2003 to January 2010, we treated 400 patients with IAT at our institution. Of these patients, 292 were evaluated with MRI scans and included in this observational study.
Jung, Simon, Mono, Marie, Findling, Oliver, Fischer, Urs, Galimanis, Aekaterini, Weck, Anja, De Marchis, Gian, Ballinari, Pietro, Gralla, Jan, Brekenfeld, Caspar, Schroth, Gerhard, Arnold, Marcel, Mattle, Heinrich, El-Koussy, Marwan   +13 more
openaire   +4 more sources

Subcortical Deep Gray Matter Pathology in Patients with Multiple Sclerosis Is Associated with White Matter Lesion Burden and Atrophy but Not with Cortical Atrophy: A Diffusion Tensor MRI Study

American Journal of Neuroradiology, 2014
BACKGROUND AND PURPOSE: The association between subcortical deep gray matter, white matter, and cortical pathology is not well understood in MS. The aim of this study was to use DTI to investigate the subcortical deep gray matter alterations and their ...
R. Cappellani, N. Bergsland, B. Weinstock-Guttman, C. Kennedy, E. Carl, D. Ramasamy, J. Hagemeier, M. Dwyer, Francesco Patti, R. Zivadinov   +9 more
semanticscholar   +1 more source

脑白质高信号与认知功能障碍：基于FLAIR高信号的定量研究 Quantitative Analysis on Correlation between Cognitive Impairment and Cerebral White Matter Hyperintensityon FLAIR Sequence

Zhongguo cuzhong zazhi, 2018
目的 利用半自动化分析软件对脑白质疏松患者不同区域白质损伤进行定量，并对其与认知功能评 分进行偏相关分析。 方法 2011年1月-2017年1月在北京天坛医院进行健康体检的50～85岁社区“健康”人群63例，对 其进行认知功能评价[简易精神状态量表（mi ni -mental state examination，MMSE）、蒙特利尔认知量表 （Montreal cognitive assessment，MoCA）]及影像学数据采集，基于液体衰减反转恢复序列定量计算全脑 ...
叶娜，Wei Wen，王金芳，石庆丽，李越秀，陈红燕，Perminder Sachdev，王拥军，张玉梅
doaj   +1 more source

Brain atrophy and lesion load in a large population of patients with multiple sclerosis [PDF]

, 2005
OBJECTIVE: To measure white matter (WM) and gray matter (GM) atrophy and lesion load in a large population of patients with multiple sclerosis (MS) using a fully automated, operator-independent, multiparametric segmentation method.
A. BRUNETTI, ALFANO B., BELLACOSA A, BONAVITA S, BONAVITA V, BRESCIAMORRA V, CAMMARATA E, CONIGLIO G, DI COSTANZO A, DINACCI D, LAVORGNA L, LIVREA P, MESSINA C, OREFICE G, PACIELLO M, PATTI F, PRINSTER A, QUARANTELLI M, QUATTRONE A, REGGIO A, RUSSO P, SALEMI G, SALVATORE M, SAVETTIERI G, SIMONE IL, TEDESCHI G, VALENTINO P   +26 more
core   +1 more source

Mechanisms of parasite‐mediated disruption of brain vessels

FEBS Letters, EarlyView.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira, Sílvia Arroz‐Madeira, Cláudio A. Franco, Sara Silva Pereira   +3 more
wiley   +1 more source

Regional Hypoperfusion Predicts White Matter Tract Degeneration in Recent Single Subcortical Infarcts

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background The association between baseline cerebral perfusion status and perilesional white matter degeneration in recent single subcortical infarcts (RSSIs) is still not well understood.
Yuying Yan, Anqi Zhang, Kai Zhang, Shuai Jiang, Lan Hong, Chen Ye, Le Cao, Tang Yang, Yi Hu, Ruosu Pan, Congjun Li, Simiao Wu, Xin Cheng, Bo Wu   +13 more
doaj   +1 more source

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

FEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman, Anna E. Lester, Brian D. Zoltowski   +2 more
wiley   +1 more source

Oxidative Glial Cell Damage Associated with White Matter Lesions in the Aging Human Brain [PDF]

, 2015
White matter lesions (WML) are common in brain aging and are associated with dementia. We aimed to investigate whether oxidative DNA damage and occur in WML and in apparently normal white matter in cases with lesions.
Akiguchi, Barber, Breteler, Chalmers, Clerici, Coppe, De Leeuw, Debette, Deursen, Devine, Englund, Englund, Fernando, Fernando, Fernando, Haider, Hasty, Ikram, Inaba, Jurk, Kee, Kobayashi, Kuilman, Launer, Lawless, Lee, Matthews, Moller, MRC-CFAS, Ovbiagele, Prins, Raiha, Rosenberg, Salminen, Scheltens, Simpson, Simpson, Simpson, Simpson, Simpson, Sonnen, Srikanth, Viana-Baptista, Von Zglinicki, Wharton   +44 more
core   +1 more source

Changes in Normal-Appearing White Matter Precede Development of White Matter Lesions [PDF]

Stroke, 2013
Background and Purpose— It is unknown whether white matter lesions (WML) develop abruptly in previously normal brain areas, or whether tissue changes are already present before WML become apparent on MRI. We therefore investigated whether development of WML is preceded by quantifiable changes in normal-appearing white matter ...
de Groot, Marius, Verhaaren, Ben, Boer, Renske, Klein, Stefan, Hofman, Bert, van der Lugt, Aad, Ikram, Arfan, Niessen, Wiro, Vernooij, Meike   +8 more
openaire   +2 more sources