Results 61 to 70 of about 298,577 (257)

Investigating the cell of origin and novel molecular targets in Merkel cell carcinoma: a historic misnomer

Molecular Oncology, EarlyView.
This study indicates that Merkel cell carcinoma (MCC) does not originate from Merkel cells, and identifies gene, protein & cellular expression of immune‐linked and neuroendocrine markers in primary and metastatic Merkel cell carcinoma (MCC) tumor samples, linked to Merkel cell polyomavirus (MCPyV) status, with enrichment of B‐cell and other immune cell
Richie Jeremian, Sriraam Sivachandran, Melissa Galati, Brandon Ramchatesingh, Hibo Rijal, Johnny Hanna, Elena Netchiporouk, May Chergui, Margaret Redpath, Samy Abou Setah, Ivan V. Litvinov   +10 more
wiley   +1 more source

White matter integrity and cognitive performance in the subacute phase after ischemic stroke in young adults

NeuroImage: Clinical
Introduction: Reduced white matter integrity outside the stroke lesion may be a potential contributor of post-stroke cognitive impairment. We aimed to investigate how a stroke lesion affects the integrity of surrounding white matter, and whether the ...
Mijntje M.I. Schellekens, Hao Li, Esther M. Boot, Jamie I. Verhoeven, Merel S. Ekker, Frederick J.A. Meijer, Roy P.C. Kessels, Frank-Erik de Leeuw, Anil M. Tuladhar   +8 more
doaj   +1 more source

Magnetic Resonance Imaging Pilot Study of Intravenous Glyburide in Traumatic Brain Injury. [PDF]

, 2020
Pre-clinical studies of traumatic brain injury (TBI) show that glyburide reduces edema and hemorrhagic progression of contusions. We conducted a small Phase II, three-institution, randomized placebo-controlled trial of subjects with TBI to assess the ...
Aldrich, Christina, Eisenberg, Howard M, Hayman, Erik G, He, Feng, Jain, Sonia, Okonkwo, David O, Pasternak, Ofer, Shenton, Martha E, Simard, J Marc   +8 more
core  

Effects of magnesium treatment in a model of internal capsule lesion in spontaneously hypertensive rats [PDF]

, 2008
<p><b>Background and Purpose:</b> The study aim was to assess the effects of magnesium sulfate (MgSO4) administration on white matter damage in vivo in spontaneously hypertensive rats.</p> <p><b>Methods:</b> ...
Gallagher, L., Lecrux, C., Lees, K.R., Macrae, I.M., McCabe, C., Muir, K., Mullin, J., Touzani, O., Weir, C.J.   +8 more
core   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

The association between cognitive function and white matter lesion location in older adults: a systematic review

Alzheimer's & Dementia, 2012
BackgroundMaintaining cognitive function is essential for healthy aging and to function autonomously within society. White matter lesions (WMLs) are associated with reduced cognitive function in older adults.
Niousha Bolandzadeh, Jennifer C. Davis, R. Tam, T. Handy, T. Liu-Ambrose   +4 more
semanticscholar   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Imaging changes in cerebral small vessel disease and risk factors of Alzheimer's disease: Meta⁃analysis

Chinese Journal of Contemporary Neurology and Neurosurgery, 2019
Objective To evaluate the imaging changes in patients with cerebral small vessel disease(cSVD) and the risk factors of Alzheimer's disease(AD). Methods Retrieve relevant retrospective case analysis and observational studies that about cSVD and the risk ...
Xin LIN, Hai⁃jiao WANG, Li⁃na ZHU, Shan⁃shan CHU, Xue⁃ping WANG, Ling LIU   +5 more
doaj   +1 more source

Predictability of cerebral palsy and its characteristics through neonatal cranial ultrasound in a high-risk neonatal intensive care unit population [PDF]

, 2010
The aim of the study is to evaluate the predictive value of various types of brain injury detected by ultrasound in the neonatal period for the occurrence of cerebral palsy and its characteristics in a large cohort of high-risk infants.
Franki, Inge, Himpens, Eveline, Oostra, Ann, Van den Broeck, Christine, VAN MAELE, GEORGES, Vanhaesebrouck, Piet   +5 more
core   +2 more sources

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source