Results 71 to 80 of about 298,577 (257)

Diffusion tensor imaging reveals diffuse white matter injuries in locked-in syndrome patients.

PLoS ONE, 2019
Locked-in syndrome (LIS) is a state of quadriplegia and anarthria with preserved consciousness, which is generally triggered by a disruption of specific white matter fiber tracts, following a lesion in the ventral part of the pons. However, the impact of
Mylene Leonard, Felix Renard, Laura Harsan, Julien Pottecher, Marc Braun, Francis Schneider, Pierre Froehlig, Frederic Blanc, Daniel Roquet, Sophie Achard, Nicolas Meyer, Stephane Kremer   +11 more
doaj   +1 more source

The demyelination and altered motor performance following electrolytic lesion in the ventrolateral white matter of spinal cord in male rats: Benefit of post-injury administration of estradiol [PDF]

, 2016
Introduction: Spinal cord injuries are accompanied with significant demyelination of axons and subsequent locomotor dysfunction. To identify the extent of damage following electrolytic lesion of ventrolateral white matter, essential area for initiation ...
Abbaszadeh, Fatemeh., Afhami, Mina., Javan, Mohammad., Jorjani, Masoumeh., Naseri, Kobra., Saghaei, Elham.   +5 more
core   +1 more source

HLA-DRB1*15 influences the development of brain tissue damage in early PPMS [PDF]

, 2014
OBJECTIVES To investigate whether (1) there were differences between HLA-DRB1*15-positive and -negative patients at baseline, and (2) HLA-DRB1*15-positive patients showed a greater development of brain and spinal cord damage, as assessed by MRI, and ...
Altmann, Daniel R, Bodini, Benedetta, Cercignani, Mara, Ciccarelli, Olga, Khaleeli, Zhaleh, Miller, David H, Ramagopalan, Sreeram, Thompson, Alan J, Tur, Carmen   +8 more
core   +1 more source

Strength through diversity: how cancers thrive when clones cooperate

Molecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken, Maartje Witsen, Emile E. Voest, Krijn K. Dijkstra   +3 more
wiley   +1 more source

Conus Medullaris Teratoma with Utilization of Fiber Tractography: Case Report

Journal of Neurological Surgery Reports, 2015
Objective Conus medullaris teratomas are very rare tumors. Traditional preoperative diagnosis depended on the findings from magnetic resonance imaging (MRI).
Fahad Alkherayf, Abdullah Faisal Arab, Eve Tsai   +2 more
doaj   +1 more source

Longitudinal segmentation of age-related white matter hyperintensities [PDF]

, 2017
Although white matter hyperintensities evolve in the course of ageing, few solutions exist to consider the lesion segmentation problem longitudinally. Based on an existing automatic lesion segmentation algorithm, a longitudinal extension is proposed. For
?, ?, Cardoso, M. Jorge, Ourselin, Sebastien, Sudre, Carole H.   +3 more
core   +1 more source

Vitamin D and Disease Severity in Multiple Sclerosis-Baseline Data From the Randomized Controlled Trial (EVIDIMS) [PDF]

, 2020
Objective: To investigate the associations between hypovitaminosis D and disease activity in a cohort of relapsing remitting multiple sclerosis (RRMS) and clinically isolated syndrome (CIS) patients.
Bellmann-Strobl, Judith, Brandt, Alexander Ulrich, Bäcker-Koduah, Priscilla, Dörr, Jan, Paul, Friedemann, Scheel, Michael, Wernecke, Klaus-Dieter, Wuerfel, Jens   +7 more
core   +2 more sources

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Diagnostic accuracy of double inversion recovery in delineation of multiple sclerosis lesions and its clinical correlation with expanded disability scoring system

The Egyptian Journal of Radiology and Nuclear Medicine, 2019
Background The aim of our work was to assess the diagnostic accuracy of a double inversion recovery (DIR) sequence in the detection of brain and spinal cord MS lesions.
Weaam Hamed, Wessam Fathi, Walaa Mahmoud, Galal Elhawary   +3 more
doaj   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source