Results 281 to 290 of about 717,864 (344)

White matter reorganization of motor and affective-motivational networks in pain-indifferent carriers of the R221W mutation

A. Tamašauskas, Irene Perini, Jan Minde, Simon S. Keller, Nicholas Fallon, Bernhard Frank, India Morrison, Andrew Marshall   +7 more
openalex   +1 more source

Adenylosuccinate Synthase 1 Deficiency Improves Energy Metabolism by Promoting Adipose Tissue Re‐esterification via Glycerol Kinase Upregulation

Advanced Science, EarlyView.
Working model of Adss1‐mediated regulation of energy metabolism in adipose tissue. In beige adipocytes, Adss1 interacts with HDAC3 in the cytoplasm, and its loss reduces nuclear HDAC3 while increasing cytosolic fractions. This redistribution suppresses HDAC activity and enhances H3K27 acetylation at the Gk promoter, leading to transcriptional ...
Jingjing Sun, Miriayi Alimujiang, Wenfei Li, Shuqin Chen, Yingying Su, Tingting Hu, Xuhong Lu, Yafen Ye, Ningning Bai, Fan Hu, Xiaoya Li, Rongrong Xu, Jun Xu, Jiarui Zhao, Yan Lu, Xiaojing Ma, Ying Yang   +16 more
wiley   +1 more source

A new link in the leukemia genetic puzzle. [PDF]

Genes Dev
Wu X, Levine RL.
europepmc   +1 more source

Full length transcriptomic profiling reveals insights into the white coat phenotype in Waardenburg syndrome mice harboring the Mitf R324del mutation

Wei Gong, Lu Ma, Zhili Feng, Xianyi Zeng, Liang Ouyang, Yihan Hu, Xianlin Liu, Jie Wen, Xiaoming Kang, Yalan Liu, Hongmin Wu, Qiancheng Jing, He Chufeng, Yong Feng   +13 more
openalex   +1 more source

eIF4E Enriched Extracellular Vesicles Induce Immunosuppressive Macrophages through HMGCR‐Mediated Metabolic Rewiring

Advanced Science, EarlyView.
Here, it is revealed that ovarian cancer cells release extracellular vesicles enriched with eIF4E, which alters protein production in macrophages. This leads to increased expression of 3‐hydroxy‐3‐methyl‐glutaryl‐coenzyme A reductase (HMGCR), boosting cholesterol synthesis and activating an immunosuppressive pathway through X‐box binding protein 1 and ...
Sonam Mittal, Minal Nenwani, Ishaque Pulikkal Kadamberi, Sudhir Kumar, Olamide Animasahun, Jasmine George, Shirng‐Wern Tsaih, Prachi Gupta, Mona Singh, Anjali Geethadevi, Chandrima Dey, Noah Meurs, Ajay Shankaran, Pradeep Chaluvally Raghavan, Deepak Nagrath, Sunila Pradeep   +15 more
wiley   +1 more source

Detection of <i>MC1R</i> Genetic Variants and Their Association with Coat Color in Asian Goats. [PDF]

Animals (Basel)
Kawaguchi F, Shaku A, Shah MK, Masangkay JS, Mannen H, Sasazaki S.   +5 more
europepmc   +1 more source

ACSS2/AATF Drives Soluble FasL‐Mediated CD8+ T Cell Apoptosis in Pancreatic Neuroendocrine Tumors

Advanced Science, EarlyView.
This study unveils that ACSS2‐driven acetate metabolism fuels histone pan‐acetylation in pancreatic neuroendocrine tumors (PNETs), remodeling the epigenetic landscape. The ACSS2/AATF axis transcriptionally activates soluble FasL (sFasL), which engages Fas receptors on infiltrating CD8+ T cells to trigger caspase‐8/3‐mediated apoptosis.
Qin Dang, Ting Wang, Yan Wang, Zeng Ye, Borui Li, Xuan Pan, Zheng Li, Guixiong Fan, Desheng Jing, Junfeng Xu, Qiangsheng Hu, Shunrong Ji, Xiaowu Xu, Xianjun Yu, Yi Qin   +14 more
wiley   +1 more source

Artificial Intelligence-Enhanced Precision Medicine Reveals Prognostic Impact of TGF-Beta Pathway Alterations in FOLFOX-Treated Early-Onset Colorectal Cancer Among Disproportionately Affected Populations. [PDF]

Int J Mol Sci
Diaz FC, Waldrup B, Carranza FG, Manjarrez S, Velazquez-Villarreal E.   +4 more
europepmc   +1 more source

Dominance of the white bulb color in onions (Allium cepa L.) changes depending on the positions of mutations in the AcMYB1 gene encoding a R2R3-MYB transcription factor

Jiwon Han, Geonjoong Kim, Haneul Choi, Jin Seong Moon, Sunggil Kim   +4 more
openalex   +1 more source

Mutation in CmGhc1 confers the white hypocotyl phenotype in melon (Cucumis melo)

Yong Yang, Rong Fan, Xuejun Zhang, Meihua Li, Yongbing Zhang, Hongping Yi, Manrui Ma, Yun Yang, Bin Liu, Xingwang Liu, Huazhong Ren   +10 more
openalex   +1 more source