Selective Targeting of Tip Endothelial Cells as a Therapeutic Strategy for Tumor Angiogenesis
Doppel protein is selectively expressed in tip endothelial cells within the tumor vasculature, where it promotes tip cell motility and stabilizes the tip cell phenotype. Targeting Doppel with monoclonal antibodies disrupts this stabilization, impairs angiogenic sprouting, and reduces tumor angiogenesis, offering a selective and druggable switch for ...
Byoungmo Kim +16 more
wiley +1 more source
Effects of reducing dietary amino acid density and stocking density on growth performance, carcass characteristics, meat quality, and occurrence of white striping in broiler chickens. [PDF]
Pekel AY +9 more
europepmc +1 more source
The Paradox of the White Striped Judo Black Belt
Bulletin On January 29, 2013, 15 leading female judokas complained that coaching personnel including the national coach of the women’s team had perpetrated violence and power harassment on them. The case attracted substantial public attention. Subsequent revelations also encompassed issues such as financial scandals and indecent conduct involving the ...
openaire
Transient Antiskyrmion‐Mediated Topological Transitions in Isotropic Magnets
A transient antiskyrmion‐mediated pathway that drives repeated stripe‐to‐skyrmion transitions is revealed, producing a net increase in topological charge in isotropic Dzyaloshinskii–Moriya interaction films. Experiments and simulations identify the antiskyrmion as a metastable excitation, enabling stochastic bitstream generation for probabilistic ...
Bingqian Dai +18 more
wiley +1 more source
Comment on “De Novo Reconstruction of 3D Human Facial Images from DNA Sequence”
This comment examines AI‐driven DNA‐based facial reconstruction, focusing on the Difface model. While such technologies promise biomedical and forensic applications, they pose significant ethical, legal, and methodological challenges. We emphasize transparency, benchmarking, and rigorous validation to avoid misinterpretation and misuse.
Jennifer K. Wagner +3 more
wiley +1 more source
This study reveals that actin remodeling regulates mitochondrial elongation as a defense strategy in plants. Flagellin perception induces fusion‐dependent elongation, supported by cortical actin bundles, to repair damage and boost ATP and ROS production.
Junxiu Hou +5 more
wiley +1 more source
Endocytic Control of Cell‐Autonomous and Non‐Cell‐Autonomous Functions of p53
NUMB Ex3‐containing isoforms localize to the plasma membrane, where they recruit p53 through SNX9 and direct it to multivesicular bodies and exosomes. Exported p53 is taken up by neighboring cells and activates nuclear programs, revealing an intercellular, exosome‐based pathway that might help establish a tumor‐suppressive microenvironment.
Roberta Cacciatore +20 more
wiley +1 more source
Single‐Crystalline Borate Covalent Organic Frameworks for Solid‐State Lithium Metal Batteries
Advancing lithium metal batteries demands novel solid‐state electrolytes. Covalent organic frameworks (COFs) offer high ion conduction via porosity and functional groups. We synthesized single‐crystalline 3D borate COF with 8.1 mS cm−1 conductivity and 0.98 Li+ transference.
Ye Tian +12 more
wiley +1 more source
An evolutionary molecular dynamics platform is used to design P1.6, a membrane‐active peptide that senses lipid packing defects in viral envelopes. P1.6 adopts a stabilized α‐helical structure upon membrane contact, disrupts virus‐like liposomes, and damages HIV‐1 particles.
Pascal von Maltitz +10 more
wiley +1 more source
Incidence of White Striping and Its Effect on the Quality Traits of Raw and Processed Turkey Breast Meat. [PDF]
Mudalal S.
europepmc +1 more source

