Results 101 to 110 of about 2,134,803 (348)

Pathogenic Neurofibromatosis type 1 gene variants in tumors of non‐NF1 patients and role of R1276

open access: yesFEBS Open Bio, EarlyView.
Somatic variants of the neurofibromatosis type 1 (NF1) gene occur across neoplasms without clinical manifestation of the disease NF1. We identified emerging somatic pathogenic NF1 variants and hotspots, for example, at the arginine finger 1276. Those missense variants provide fundamental information about neurofibromin's role in cancer.
Mareike Selig   +7 more
wiley   +1 more source

COVID-19, Climate, and White Supremacy: Multiple Crises or One?

open access: yesJournal for the History of Environment and Society, 2020
This essay asks whether there is a connection between the three crises that are currently reverberating globally, the climate crisis, the COVID-19 crisis and the ‘crisis of white supremacy’.
Eleonora Rohland
doaj   +1 more source

Enemy and Ally: Religion in Loving v. Virginia and Beyond [PDF]

open access: yes, 2018
Throughout the Loving case, religion appeared both overtly and subtly to endorse or lend credibility to the arguments against racial mixing. This use of religion is unsurprising given that supporters of slavery, white supremacy, and segregation have, for
Eisenstadt, Leora F.
core   +1 more source

States’ Rights, Southern Hypocrisy, and the Crisis of the Union [PDF]

open access: yes, 2012
This article explores the arguments used by southern secessionists to explain why they left the Union. The article demonstrates that support for states\u27 rights was not the main reason for secession, and that on the contrary, most of the slave ...
Björk, Jonas, Stafström, Sven
core   +3 more sources

Down‐regulation of Shh in the hair follicles of mice during chemotherapy‐induced hair loss is mediated by the JAK/STAT1 signaling pathway

open access: yesFEBS Open Bio, EarlyView.
We found that during chemotherapy‐induced alopecia (CIA), Sonic hedgehog (Shh) expression significantly decreased in hair follicle Shh+ cells, whereas the Janus‐activated kinase/signal transducer and activator of transcription 1 (JAK/STAT1) signaling pathway was markedly activated.
Ruifang Fan   +6 more
wiley   +1 more source

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

open access: yesFEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani   +6 more
wiley   +1 more source

We Need Charles Mills More Than Ever

open access: yesMedia Theory
This article uses a no reply racist email I received in 2023 as its point of departure for thinking through the importance of The Racial Contract in theorizing about contemporary ‘post-race’ racism’s cultural life because of the prevalent discourse that
Shirley Anne Tate
doaj   +1 more source

[Review of] Phillipa Kafka. (Un)Doing the Missionary Position: Gender Asymmetry in Contemporary Asian American Women\u27s Writing [PDF]

open access: yes, 1997
Phillipa Kafka\u27s clever book title turns on her deconstruction of what she sees as a simultaneous patriarchal and racist orientation of some contemporary literary criticism, akin to the unquestioned, naturalized supremacy presumed by agents of ...
Goldstein-Shirley, David
core   +1 more source

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

open access: yesFEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn   +4 more
wiley   +1 more source

White Supremacy Towards Igbo People in Chinua Achebe's Things Fall Apart [PDF]

open access: yes, 2013
The phenomenon of colonization is important part in a history. Colonization iscontributed in the development of nations in the world. The concept of 3G (Gold,Gospel, and Glory) which becomes the background of European colonizers travelaround. Africa as a
AMALIA, F. (FITRAH)
core  

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