Results 121 to 130 of about 145,460 (297)
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
AJIL UnboundWith the end of the slave trade and the general emancipation of slaves, the problems of race did not disappear but simply were transformed ...
Christopher Gevers
doaj +1 more source
Rethinking White Supremacy: who counts in 'Whiteworld' [PDF]
, 2006 The article addresses the nature of power relations that sustain and disguise white racial hegemony in contemporary ‘western’ society. Following the insights offered by critical race theory (CRT), white supremacy is conceived as a comprehensive condition
Gillborn, David
core +1 more source
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Molecular Oncology, EarlyView.We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto +8 more
wiley +1 more source
Reader Expectation and the Ethnic Rhetorics: The Problem of the Passing Subaltern in Who Would Have Thought It? [PDF]
, 2005 Mrs. Norval... hoped...Lola might be now all black or all white, no matter which, only not with those ugly white spots. - Who Would Have Thought It? 1872 (78) But these snowy, equable and smooth spots ... sometimes occur amongst our own people.
Stevenson, Pascha A.
core +1 more source
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
The Double-Edged Nature of Whiteness for Multiracial People with White Ancestry in the US and UK
GenealogyThe privileges of Whiteness have been theorized and debated for some decades. Because White privilege has been manifested, historically, in myriad forms, it has been possible to treat the privileges of Whiteness as a given, even when its changing ...
Miri Song
doaj +1 more source
When ‘White Devils’ Join the Deen: White American Converts to Islam and the Experience of Non-Normative Whiteness. [PDF]
, 2015 This paper focuses on white converts to Islam as anomalous individuals in a world where race and faith have become closely intertwined. Because they disrupt classic understandings of whiteness and enter a setting, the Muslim community, where whiteness is
Galonnier, Juliette
core +2 more sources
Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib
Molecular Oncology, EarlyView.WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute +17 more
wiley +1 more source