ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Greenness, Whiteness, and Blueness Assessment With a Novel and Fully Validated HPLC Method for Simultaneous Analysis of Lumacaftor and Ivacaftor in Sweat. [PDF]
Int J Anal ChemLevent S, Elriş A, Özcan S, Can NÖ.
europepmc +1 more source
Book Reviews: White Servitude in Colonial America: An Economic Analysis, by David Galenson
, 1982 George W. Franz
openalex +1 more source
SynchronizingExcited-State Lifetimes for Bright andLong-Lived White Phosphorescent Carbon Nanodots
Xiang-Yu Li (3989621) +9 more
openalex +1 more source
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
Assessment of bleaching procedures on the optical properties, surface roughness and microhardness of single-shade resin composites: an in-vitro study. [PDF]
BMC Oral HealthAtilan Yavuz S +2 more
europepmc +1 more source
Possessing Polynesians: The Science of Settler Colonial Whiteness in Hawai’i and Oceania By Maile Arvin. (Durham: Duke University Press, 2019). [PDF]
, 2020 Lee, Sarah
core
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Effect of a Home Bleaching Gel Containing Chitosan and Theobromine on Tooth Surface Roughness, Microhardness, and Colour Change. [PDF]
GelsTemizyurek S, Gursel Surmelioglu D.
europepmc +1 more source
Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source