Results 81 to 90 of about 12,388,974 (287)

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Reinventing Significance: Reflections on Recent Whiteness Studies in Zimbabwe

Africa Spectrum, 2014
Review Article: Josephine Lucy Fisher (2010), Pioneers, Settlers, Aliens, Exiles: The Decolonisation of White Identity in Zimbabwe, Canberra: Australian National University Press, ISBN 978-1-921-66614-8 (pbk.), xiii + 276 pp. David McDermott Hughes (2010)
Rory Pilossof
doaj  

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Shadows along the Waccamaw

Southern Spaces, 2008
Dan Albergotti, Self-Portrait as Shadow on Skeletal Shed, 2008. Dan Albergotti reads five poems in and around his current home of Conway, South Carolina, in locations that include the Waccamaw River and nearby Pawley's Island.
Dan Albergotti
doaj   +1 more source

Critical race and whiteness studies: What has been, what might be (Editorial)

, 2019
After a hiatus of several years, Critical Race and Whiteness Studies Journal is reemerging. We do so in recognition of the exceptional scholarship the Journal has produced in the past with writers like Nicoll, Moreton-Robinson, Randell-Moon, Riggs ...
Vass, Greg, Kennedy, Tristan, Moodie, Nikki, Schulz, Sam   +3 more
core  

Introduction: Intersecting whiteness, interdisciplinary debates

, 2010
This article sets out the purview of this special issue of Ethnicities. Whiteness Studies has moved from the margins and has become an accepted focus for study in Critical Race Studies.
Daniel Conway, Steyn, M., Conway, D., Steyn, Melissa, Conway, Daniel, Melissa Steyn   +5 more
core   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source