Results 151 to 160 of about 98,113 (268)

Autocrine Netrin‐1 Signaling in Hepatic Stellate Cells Drives Liver Fibrosis and Diet‐Induced Metabolic Dysfunction‐Associated Steatohepatitis in Mice

Advanced Science, EarlyView.
Netrin‐1 expression is upregulated in hepatic stellate cells (HSCs) during metabolic dysfunction–associated steatohepatitis and injury‐mediated liver fibrosis. Secreted Netrin‐1 establishes an autocrine positive feedback loop by binding to UNC5B receptors on HSCs.
Jiahui Zhao, Yajie Peng, Hongyan Lei, Tianyi Wang, Huajuan Wang, Bo Wang, Jin Li, Xiaoying Li, Xuelian Xiong   +8 more
wiley   +1 more source

Non-Pharmacological Strategies for Managing Sarcopenia in Chronic Diseases

Clinical Interventions in Aging
Jiawen Hu,1,2 Yiwen Wang,1 Xiaojian Ji,1 Yinan Zhang,1 Kunpeng Li,1 Feng Huang1 1Department of Rheumatology and Immunology, First Medical Center of Chinese PLA General Hospital, Beijing, China; 2Medical School of Chinese PLA, Beijing, ChinaCorrespondence:
Hu J, Wang Y, Ji X, Zhang Y, Li K, Huang F   +5 more
doaj  

Outcomes Addressed by Whole-Body Electromyostimulation Trials in Sportspeople and Athletes-An Evidence Map Summarizing and Categorizing Current Findings. [PDF]

Sports (Basel)
Reinhardt S, Berger J, Kohl M, von Stengel S, Uder M, Kemmler W.   +5 more
europepmc   +1 more source

Magnetically Responsive Piezoelectric Nanocapacitors Enhance Neural Recovery Following Spinal Cord Injury via Targeted Spinal Magnetic Stimulation

Advanced Science, EarlyView.
This study presents a novel “in vivo–in vitro” therapeutic strategy for spinal cord injury by leveraging magnetically responsive piezoelectric nanomaterials. These nanomaterials enable targeted delivery of localized electrical stimulation at the injury site through noninvasive external magnetic actuation, thereby promoting axonal regeneration and ...
Zhihang Xiao, Tingting Li, Lechi Zhang, Chunya Xia, Zelin Su, Xuyan Ren, Yingjie Fan, Zerui Wu, Yaobo Liu, Min Su   +9 more
wiley   +1 more source

Testosterone and Long-Pulse-Width Stimulation (TLPS) on Denervated Muscles and Cardio-Metabolic Risk Factors After Spinal Cord Injury: A Pilot Randomized Trial. [PDF]

Cells
Gorgey AS, Khalil RE, Alazzam A, Gill R, Rivers J, Caruso D, Garten R, Redden JT, McClure MJ, Castillo T, Goetz L, Chen Q, Lesnefsky EJ, Adler RA.   +13 more
europepmc   +1 more source

Amodiaquine Enhances Anti‐Melanoma Efficacy of Attenuated Salmonella via Targeting Glutathione Reductase in Neutrophils

Advanced Science, EarlyView.
This study shows that Salmonella VNP20009 recruits pro‐tumor neutrophils that reduce its anticancer efficacy. Combining VNP with amodiaquine selectively eliminates these neutrophils by targeting glutathione reductase. A GR‐shRNA‐loaded VNP strain was further developed, demonstrating an innovative strategy integrating drug repurposing with synthetic ...
Wanfa Dong, Chunyuan Zhao, Chengxi Li, Lin Weng, Zehan Ji, Peiqi Li, Jiqiang Lu, Danni Liu, Anni Yu, Tianyi Jiang, Shaokai Huang, Heng Liu, Xiao Chen, Zichun Hua   +13 more
wiley   +1 more source

Neuromuscular Electrical Stimulation Plus Nutritional Counseling Attenuates Thigh Muscle Thickness Loss in Hospitalized Cancer Patients. [PDF]

Pathophysiology
Gomes TLN, Borges TC, Ivo JFM, Mainardi LG, Abadio RGC, Wall BT, Pimentel GD.   +6 more
europepmc   +1 more source

A Novel CYP2E1 Inhibitor, 4‐Methyl‐5‐Acetylthiazole (Q11), Alleviates Obesity Via Modulating Adipose Inflammation and Mitochondrial Dysfunction

Advanced Science, EarlyView.
Obesity involves chronic inflammation and mitochondrial dysfunction. This study identifies cytochrome P450 2E1 (CYP2E1) as a novel inflammatory target in adipose tissue. Its activity increases in obese mice and correlates with inflammation and mitochondrial impairment.
Jinhuan Qiu, Liyuan Gao, Liyang Wang, Xueke Wang, Lin Jia, Mengyan Deng, Liming Tang, Qiang Wen, Na Gao, Haiwei Xu, Hailing Qiao   +10 more
wiley   +1 more source

Effects of Whole-Body Electromyostimulation on Jumping, Sprinting and Agility Performance in Sportspeople and Athletes: Systematic Review and Meta-Analysis. [PDF]

J Funct Morphol Kinesiol
Püttner M, Kohl M, von Stengel S, Filipovic A, Uder M, Kemmler W.   +5 more
europepmc   +1 more source

Soft‐Drug‐Inspired MnSTF Nano‐Adjuvant for Safe and Synergistic cGAS–STING Activation in Tumor Immunotherapy

Advanced Science, EarlyView.
This study introduces MnSTF, a soft‐drug‐inspired nanoadjuvant that overcomes the systemic toxicity of STING agonists. Through Mn2+ coordination with an ENPP1 inhibitor, it enables safe cGAS‐STING activation, remodels the tumor immune microenvironment, and synergizes with radiotherapy or vaccines to elicit robust antitumor immunity.
Guangfei Sun, Jiancheng Pan, Rui Li, Ruoxi Li, Ziyan Liu, Jinhui Wu, Tingsheng Lin, Yiqiao Hu, Ahu Yuan   +8 more
wiley   +1 more source