Results 201 to 210 of about 98,113 (268)

PROTAC‑Mediated HMGCR Depletion Reprograms Lipid Metabolism in Breast Cancer to Potentiate Photoimmunotherapy via Ferroptosis

Advanced Science, EarlyView.
This work introduces a study that identifies HMGCR as a novel target in TNBC and develops a light‐gated PROTAC nanomedicine. Upon irradiation, this agent selectively degrades HMGCR, reprogramming lipid metabolism to induce ferroptosis and potent antitumor immunity, thereby significantly enhancing photoimmunotherapy efficacy.
Tong Su, Guang Li, Yudong Guan, Qi Tian, Youzhi Qi, Yanqiu Zhang, Wenqian Wei, Xinxin Duan, Jiaxin Rui, Hongyan Zhu, Zengping Lin, Changchuan Xie, Zheni Xu, Yaying Wu, Xin Peng, Zhenjie Wang, Kun Chen, Xiaoyan Xin, Bing Zhang   +18 more
wiley   +1 more source

Electrical stimulation in upper limb assistance: opportunities and challenges. [PDF]

Front Neurosci
Routledge N, Zhang D, Metcalfe B.
europepmc   +1 more source

ROS‐Responsive Wedelolactone Hydrogel Promotes Intervertebral Disc Repair by Disrupting the NF‐κB–LCN2 Inflammatory Feedback Loop

Advanced Science, EarlyView.
A mechanically robust, ROS‐responsive hydrogel is engineered to treat intervertebral disc degeneration by targeting the NF‐κB–LCN2 inflammatory feedback loop. By delivering wedelolactone specifically within oxidative niches, this system disrupts macrophage–disc cell crosstalk.
Zimei Wu, Yan Xu, Lang Qin, Zemin Ling, Yingjie Mai, Xiong Tian Guo, Jiajia Chen, Leping Yan, Lin Wang, Liming Bian, Fuxin Wei   +10 more
wiley   +1 more source

Exploratory Evaluation for Functional Changes of Six-Month Systematic Non-Invasive Electrical Stimulation in a Whole-Body Suit on Children with Cerebral Palsy GMFCS III-V. [PDF]

Neurol Int
Torabi TP, Mortensen K, Michelsen JS, Wong C.   +3 more
europepmc   +1 more source

Dual‐Responsive Yarn‐Based Artificial Muscles for Adaptive Thermal Management

Advanced Science, EarlyView.
Inspired by the conscious movements of skeletal muscle, a novel hybrid yarn‐based artificial muscle (HYAM) coupling moisture actuation with controllable recovery is developed. This unique design increases actuation stroke by 128% and shortens recovery time by 91%. This unique design enhances the actuation stroke by 128% and reduces the recovery time by
Mengjiao Pan, Xiaohui Zhang, Jinhao Xu, Ziqi Li, Junjie Wang, Qirui Zhang, Yi Liu, Hongfei Yang, Kinor Jiang, Albert Chan, Yucan Peng, Dahua Shou   +11 more
wiley   +1 more source

Whole-body vibration as an effective sports competition warm-up: a randomized controlled trial in a young and healthy population. [PDF]

Front Physiol
Amato A, Petrigna L, Amorim PRDS, Wenxin X, Musumeci G.   +4 more
europepmc   +1 more source

Photocatalytic Micro/Nanomotors Functioning in the Near‐Infrared Window for Biomedical Applications

Advanced Science, EarlyView.
This review focuses on near‐infrared responsive photocatalytic micro/nanomotors based on inorganic materials, with particular emphasis on minimally invasive biomedical applications. It discusses material strategies for achieving near‐infrared responsiveness, including heterostructure construction, upconversion nanoparticle integration, defect ...
Yufen Chen, João Marcos Gonçalves, Katherine Villa   +2 more
wiley   +1 more source

Test-Retest Variability and Reliability of Volitional and Non-Volitional Assessments of Muscle Endurance in Healthy Humans. [PDF]

Med Sci Sports Exerc
Metcalfe AJ, Mills E, Chalder T, Jolley CJ, Rafferty GF.   +4 more
europepmc   +1 more source

Ultrasoft Yet Tough Multifunctional Organohydrogels Enabled by Molecular Chain Lubrication Strategy for Self‐Powered Wearable Electronics

Advanced Science, EarlyView.
An ultrasoft yet tough organohydrogel (AQGL) with 5800% stretchability and 14.3 kPa modulus is developed via a novel molecular chain lubrication strategy. It features optical transparency, drying/freezing (−40°C) tolerance, antibacterial activity, conductivity, self‐healing, and adhesiveness.
Si Wang, Lin Hu, Mingbo Pu, Mingfeng Xu, Tao Zhou, Hanbing Rao, Xiong Li, Xiaoliang Ma, Gehong Su, Xiangang Luo   +9 more
wiley   +1 more source

Overuse-Induced Muscle Disorder: Establishing a Rat Model to Unravel the Role of Fibro-Adipogenic Progenitor Cells in Intramuscular Fibrosis. [PDF]

J Orthop Res
Fusagawa H, Sato T, Naito A, Tokuda N, Yamauchi N, Uezumi A, Uezumi M, Saito Y, Fusagawa M, Takashima H, Ichise N, Ogawa T, Karaushi T, Tohse N, Feeley B, Liu X, Teramoto A, Yamada T.   +17 more
europepmc   +1 more source