Results 211 to 220 of about 98,113 (268)

PIK3CA Mutations Downregulate PPT1 to Promote Adipogenesis by Suppressing P300 Depalmitoylation and Phase Separation

Advanced Science, EarlyView.
This study demonstrates that somatic PIK3CA mutations suppress PPT1 expression via activation of the PI3K–AKT–c‐JUN axis. This reduction in PPT1 weakens its interaction with P300, thereby increasing palmitoylation at C1176 of P300 and protecting P300 from lysosomal degradation.
Hongrui Chen, Zening Huang, Rui Chang, Wei Gao, Yajing Qiu, Bin Sun, Chen Hua, Xiaoxi Lin   +7 more
wiley   +1 more source

Myo-MOVES: a custom electrical stimulation system for functional studies of 3D bioengineered muscle.

Lab Chip
Ruiz-Gutiérrez M, Tejedera-Villafranca A, Pujol-Pinto S, Ramón-Azcón J, Fernández-Costa JM.   +4 more
europepmc   +1 more source

Exercise-Based Mechanotherapy: From Biomechanical Principles and Mechanotransduction to Precision Regenerative Rehabilitation. [PDF]

Int J Mol Sci
Jin GZ.
europepmc   +1 more source

Dorsal Raphe VIP Neurons Are Critical for Survival‐Oriented Vigilance

Advanced Science, EarlyView.
DRNVIP neurons in mice and primates are strategically positioned to influence the central extended amygdala via feedback loops. They regulate the excitability of PKC‐δ neurons in the ovBNST and CeA through glutamate release. Their ablation heightens activity in these regions, disrupts active‐phase sleep architecture, enhances risk assessment behaviors ...
Adriane Guillaumin, Emma Perrot, Thibault Dhellemmes, Laura Boi, Daniel De Castro Medeiros, Christelle Glangetas, Sylvie Dumas, Sandra Dovero, Nathalie Biendon, Elodie Ladeveze, Maëlle Hardel, Marc Landry, Erwan Bezard, Jérôme Baufreton, Gilberto Fisone, François Georges   +15 more
wiley   +1 more source

Effects of non-pharmacological interventions on body composition and physical function in older women with sarcopenic obesity: a meta-analysis. [PDF]

Front Public Health
Zeng C, Du H, Zheng J, Wang Y, Liu K, Chen Z.   +5 more
europepmc   +1 more source

A LDH‐Based Supramolecular Photosensitizer‐Functionalized Bioactive Glass Scaffold for Integrated Postoperative Osteosarcoma Recurrence Prevention and Bone Regeneration

Advanced Science, EarlyView.
An intercalation assembly strategy is proposed to construct a novel LDH‐based supramolecular photosensitizer, which exhibits outstanding reactive oxygen species generation activity under 1270 nm laser irradiation. The deposition of supramolecular photosensitizer onto the surface of bioactive glass scaffolds results in the development of an innovative ...
Tao Wang, Yixin Bian, Tingting Hu, Mengyang Li, Yuqin Tan, Yu Yang, Xiaolan Jian, Xisheng Weng, Chaoliang Tan, Ruizheng Liang   +9 more
wiley   +1 more source

Editorial: Responses and adaptations to novel exercise modalities. [PDF]

Front Physiol
Ballard KD, Timmerman KL.
europepmc   +1 more source

A smart headband for multimodal physiological monitoring in human exercises

Advanced Science, EarlyView.
A novel smart headband incorporating a thermal‐sensation‐based electronic skin is presented for continuous and accurate multimodal physiological monitoring, including pulse waveforms, total metabolic energy expenditure, heart rate, and forehead temperature, across both static and dynamic daily activities.
Shiqiang Liu, Guanxing Chen, Jingyi Peng, Shuo Tian, Qian Mao, Caise Wei, Jinfeng Yuan, Rong Zhu   +7 more
wiley   +1 more source

Home-based Functional Electrical Stimulation for Treatment of Patients with Facial Nerve Paralysis. [PDF]

Restor Neurol Neurosci
Geitner M, Ballmaier J, Krauß J, Meincke G, Kuttenreich AM, Arnold D, Mayr W, Klingner C, Mastryukova V, Guntinas-Lichius O, Volk GF.   +10 more
europepmc   +1 more source