Results 171 to 180 of about 157,766 (271)

Whole-Genome Duplication Reshapes Adaptation: Autotetraploid Arabidopsis arenosa Leverages its High Genetic Variation to Compensate for Selection Constraints. [PDF]

Mol Biol Evol
Celestini S, Lipánová V, Vlček J, Kolář F.   +3 more
europepmc   +2 more sources

Allelic Imbalance and Chromothripsis Lead to Diversity in Japanese Tumor Genomes With Whole-Genome Duplication. [PDF]

Cancer Sci
Hatakeyama K, Nagashima T, Ohnami S, Ohnami S, Maruyama K, Ohshima K, Shimoda Y, Naruoka A, Kenmotsu H, Urakami K, Akiyama Y, Yamaguchi K.   +11 more
europepmc   +1 more source

SIRT5–RAC2 Axis Drives Monocyte‐to‐Macrophage Differentiation to Promote Inflammatory Injury in Premature Ovarian Insufficiency

Advanced Science, EarlyView.
SIRT5 desuccinylates and stabilizes RAC2, activating CSF1R‐dependent signaling to drive monocyte differentiation into M0 macrophages and their polarization toward pro‐inflammatory M1 phenotypes in CTX‐induced premature ovarian insufficiency. Inhibiting the SIRT5‐RAC2 axis attenuates inflammation, reduces granulosa cell apoptosis, and preserves ...
Wenjing TanTai, Yaqi Li, Shengnan Liu, Minjuan Wu, Zhixiao Liu, Junfeng Jiang, Jingjing Chen, Xiaoding Xu, Li Li, Chaoqun Li, Fang Zhao, Ye Liu, Haitao Ni, Tengfei Zhang, Mingjuan Xu, Chaofeng Han   +15 more
wiley   +1 more source

Assessing the Impact of Whole Genome Duplication on Gene Expression and Regulation During Arachnid Development. [PDF]

Genome Biol Evol
Aase-Remedios ME, Leite DJ, Janssen R, McGregor AP.   +3 more
europepmc   +1 more source

cuteHap: Haplotype‐Aware Structural Variant Detection in Phased Long‐Read Sequencing Data

Advanced Science, EarlyView.
cuteHap is a haplotype‐aware structural variant detection method designed for phased long‐read sequencing. By employing self‐adaptive clustering and credibility‐prioritized beam search algorithms, cuteHap generates accurate haplotype‐resolved calls and outperforms state‐of‐the‐art tools.
Shuqi Cao, Yadong Liu, Miao Cui, Runtian Gao, Weimin Guo, Guohua Wang, Yadong Wang, Tao Jiang   +7 more
wiley   +1 more source

Whole genome duplication drives transcriptome reprogramming in response to drought in alfalfa. [PDF]

Plant Cell Rep
Santoro DF, Anderson AW, Alavi SN, Malatesta Pierleoni VA, Rosellini D.   +4 more
europepmc   +1 more source

Parallel Nonfunctionalization of CK1δ/ε Kinase Ohnologs Following a Whole-Genome Duplication Event. [PDF]

Mol Biol Evol, 2023
Evans-Yamamoto D, Dubé AK, Saha G, Plante S, Bradley D, Gagnon-Arsenault I, Landry CR.   +6 more
europepmc   +1 more source

Selenoprotein H Functions as a PPARα Coactivator to Link Selenium Homeostasis to Hepatic Lipid Metabolism and Protect against Steatohepatitis

Advanced Science, EarlyView.
Our study identifies selenium deficiency as a hallmark of MASH pathogenesis. Dietary selenium supplementation enhances hepatic fatty acid oxidation (FAO) and attenuates MASH progression by activating the PPARα pathway via selenoprotein H (SELENOH). This selenium‐SELENOH‐PPARα nexus redefines the functional scope of selenoproteins, moving from redox ...
Yuwei Zhang, Yuchen Wang, Binbin Li, Xin Li, Chenyu Liu, Yanhao Chen, Cheng Tian, Dongmei Wang, Xiaosong Gu, Chunping Jiang, Yuda Wei, Qiurong Ding   +11 more
wiley   +1 more source

Whole Genome Duplication in the Genomics Era: The Hidden Gems in Invertebrates? [PDF]

Genome Biol Evol
Au HM, Nong W, Hui JHL.
europepmc   +1 more source

Independent rediploidization masks shared whole genome duplication in the sturgeon-paddlefish ancestor. [PDF]

Nat Commun, 2023
Redmond AK, Casey D, Gundappa MK, Macqueen DJ, McLysaght A.   +4 more
europepmc   +1 more source