Results 181 to 190 of about 155,426 (291)

Parallel Nonfunctionalization of CK1δ/ε Kinase Ohnologs Following a Whole-Genome Duplication Event. [PDF]

Mol Biol Evol, 2023
Evans-Yamamoto D, Dubé AK, Saha G, Plante S, Bradley D, Gagnon-Arsenault I, Landry CR.   +6 more
europepmc   +1 more source

Genome Sequencing in 19 Families With Bladder Exstrophy and Epispadias Complex Indicates Involvement of the ADGR‐Gene Family

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Bladder exstrophy and epispadias complex (BEEC) is one of the most severe congenital malformations of the urogenital tract, significantly impacting continence, sexual function, and renal function. To date, the only recurrent genetic aberration identified is the 22q.11.2 microduplication, but several candidate regions and genes including ...
Agneta Nordenskjöld, Samara Alm, Jesper Eisfeldt, Jia Cao, Magnus Anderberg, Gillian Barker, Hans Matsson, Gundela Holmdahl, Anna Lindstrand, Kristina Lagerstedt‐Robinson   +9 more
wiley   +1 more source

Whole-genome duplication increases genetic diversity and load in outcrossing Arabidopsis arenosa. [PDF]

Proc Natl Acad Sci U S A
Vlček J, Hämälä T, Vives Cobo C, Curran E, Šrámková G, Slotte T, Schmickl R, Yant L, Kolář F.   +8 more
europepmc   +1 more source

Independent rediploidization masks shared whole genome duplication in the sturgeon-paddlefish ancestor. [PDF]

Nat Commun, 2023
Redmond AK, Casey D, Gundappa MK, Macqueen DJ, McLysaght A.   +4 more
europepmc   +1 more source

Prenatal Evaluation of RNU4‐2 Variants in Fetuses With Central Nervous System Anomalies

American Journal of Medical Genetics Part C: Seminars in Medical Genetics, EarlyView.
ABSTRACT Fetal central nervous system (CNS) anomalies are among the most common congenital malformations, yet the overall prenatal diagnostic yield of current genetic testing remains below 40%. Variants in RNU4‐2, a non‐coding gene encoding the U4 small nuclear RNA (snRNA), have recently been linked to a novel highly recurrent dominant ...
Yiyao Chen, Li Gao, Xu Han, Yunyun Cao, Lanlan Zhang, Yi Wu, Xinrong Zhao, Wenjing Hu, Ruiyu Ma, Renyi Hua, Niu Li, Yanlin Wang, Jian Wang, Shuyuan Li   +13 more
wiley   +1 more source

Whole-Genome Sequence of Potamopyrgus antipodarum-A Model System for the Maintenance of Sexual Reproduction-Reveals a Recent Whole-Genome Duplication. [PDF]

Genome Biol Evol
Jalinsky J, McElroy KE, Sharbrough J, Bankers L, Fields PD, Higgins C, Toll C, Boore JL, Logsdon JM, Neiman M.   +9 more
europepmc   +1 more source

Telomere-to-telomere pear (Pyrus pyrifolia) reference genome reveals segmental and whole genome duplication driving genome evolution. [PDF]

Hortic Res, 2023
Sun M, Yao C, Shu Q, He Y, Chen G, Yang G, Xu S, Liu Y, Xue Z, Wu J.   +9 more
europepmc   +1 more source

Zebrafish and CRISPR—A synergistic approach to decipher and cure human diseases

Animal Models and Experimental Medicine, EarlyView.
Zebrafish, with high genetic homology to humans, serves as a powerful vertebrate model for disease modeling and drug discovery. Integration of CRISPR/Cas9 technology enables precise genome editing, facilitating the development of translational models for human diseases.
Manikandan Sivaprakasam, Aashika Raagavi Jeanpierre, Salma Mohammed, Rajesh Srinivasan, Aman Kumar Mohanty   +4 more
wiley   +1 more source

Whole-genome duplication leads to significant but inconsistent changes in climatic niche. [PDF]

Proc Natl Acad Sci U S A
Meirmans PG, Kolář F.
europepmc   +1 more source

Whole-Genome Duplication and Genome Instability in Cancer Cells: Double the Trouble. [PDF]

Int J Mol Sci, 2023
Lau TY, Poon RYC.
europepmc   +1 more source