Results 171 to 180 of about 1,170,509 (350)

Longitudinal Data Analysis for Genetic Studies in the Whole‐Genome Sequencing Era [PDF]

, 2014
Zheyang Wu, Yi‐Juan Hu, Phillip E. Melton   +2 more
openalex   +1 more source

Simultaneous Emergence of Multidrug-Resistant Candida auris on 3 Continents Confirmed by Whole-Genome Sequencing and Epidemiological Analyses

Clinical Infectious Diseases, 2017
S. Lockhart, Kizee A. Etienne, S. Vallabhaneni, J. Farooqi, A. Chowdhary, N. Govender, A. Colombo, B. Calvo, Christina A. Cuomo, C. Desjardins, E. Berkow, M. Castanheira, R. Magobo, K. Jabeen, R. Asghar, J. Meis, Brendan R. Jackson, T. Chiller, A. Litvintseva   +18 more
semanticscholar   +1 more source

An optimized protocol to detect high‐throughput DNA methylation from custom targeted sequences on 96 samples simultaneously

FEBS Open Bio, EarlyView.
Workflow of a high‐throughput technology for epigenotyping of differentially methylated CpGs in specific regions of the genome. The protocol works with small amounts of DNA extracted from blood or semen. The protocol consists of both enzymatic conversion of unmethylated cytosines and capture by hybridization with a custom panel.
Nathalie Iannuccelli, Sophie Valière, Julien Sarry, Cécile Donnadieu, Julie Demars   +4 more
wiley   +1 more source

Transcriptional regulation of neuropeptide receptors underlies context‐dependent adaptation in Drosophila melanogaster

FEBS Open Bio, EarlyView.
Under environmental changes, the expression level of neuropeptide (NP) and neuropeptide receptor (NPR) genes changes to confer context‐dependent adaptation to the model organism Drosophila melanogaster. Through finding more regulatory elements in the NPR genes in comparison with their ligands (NPs), we found that NPR‐biased transcriptional regulation ...
SeungHeui Ryu, Yanan Wei, Zekun Wu, Tianmu Zhang, DoHoon Lee, Hadi Najafi, Woo Jae Kim   +6 more
wiley   +1 more source

Whole genome sequencing of nearly isogenic WMI and WLI inbred rats identifies genes potentially involved in depression and stress reactivity [PDF]

, 2021
Tristan V. de Jong, Panjun Kim, Victor Guryev, Megan K. Mulligan, Robert W. Williams, Eva E. Redei, Hao Chen   +6 more
openalex   +1 more source

The impact of Hnrnpl deficiency on transcriptional patterns of developing muscle cells

FEBS Open Bio, EarlyView.
We performed nanopore whole‐transcriptome sequencing comparing RNA from Hnrnpl‐knockdown versus control C2C12 myoblasts to investigate the contributions of Hnrnpl to muscle development. Our results indicate that Hnrnpl regulates the expression of genes involved with Notch signaling and skeletal muscle, particularly splicing patterns of specific muscle ...
Hannah R. Littel, Mekala Gunasekaran, Audrey L. Daugherty, Natalya M. Wells, Johnnie Turner, Christine C. Bruels, Christina A. Pacak, Isabelle Draper, Peter B. Kang   +8 more
wiley   +1 more source

Genome-wide discovery of di-nucleotide SSR markers based on whole genome re-sequencing data of Cicer arietinum L. and Cicer reticulatum Ladiz [PDF]

, 2023
Duygu Sarı, Hatice Sari, Cengiz İkten, Cengiz Toker   +3 more
openalex   +1 more source

Reflections on the Cost of Low-Cost Whole Genome Sequencing: Framing the Health Policy Debate [PDF]

, 2013
The cost of whole genome sequencing is dropping rapidly. There has been a great deal of enthusiasm about the potential for this technological advance to transform clinical care.
Biesecker, Barbara, Borry, Pascal, Bubela, Tania, Carroll, June C., Caulfield, Timothy, Cho, Mildred K., Cook-Deegan, Robert, Etchegary, Holly, Evans, Jim, Fishman, Jennifer, Hogarth, Stuart, Joly, Yann, Kato, Kazuto, Lee, Sandra Soo-Jim, McCabe, Christopher, McGuire, Amy, Miller, Fiona A., Ossorio, Pilar, Pullman, Daryl, Ravitsky, Vardit, Rothenberg, Karen H., Rousseau, Francois, Sankar, Pamela, Szego, Michael J., Ungar, Wendy J., Wilson, Brenda   +25 more
core   +1 more source

Short‐term actions of epigalocatechin‐3‐gallate in the liver: a mechanistic insight into hypoglycemic and potential toxic effects

FEBS Open Bio, EarlyView.
Epigallocatechin‐3‐gallate (EGCG) acutely inhibited gluconeogenesis and enhanced glycolysis, glycogenolysis, and fatty acid oxidation in perfused rat livers. Mechanistic assays revealed mitochondrial uncoupling, inhibition of pyruvate carboxylation and glucose‐6‐phosphatase, shift of NADH/NAD+ ratios toward oxidation, and loss of membrane integrity ...
Carla Indianara Bonetti, Bruna Lopes Correia, Francielle Cristina Nakamura Manicardi, Nairana Mithieli de Queiroz Eskuarek Melo, Vanesa de Oliveira Pateis, Jurandir Fernando Comar, Anacharis Babeto de Sá‐Nakanishi, Adelar Bracht, Lívia Bracht   +8 more
wiley   +1 more source

Additional file 2 of Genome-wide detection of signatures of selection in indicine and Brazilian locally adapted taurine cattle breeds using whole-genome re-sequencing data

, 2020
Elisa Peripolli, Christian Reimer, Ngoc-Thuy Ha, Johannes Geibel, Marco Antônio Machado, J. C. do C. Panetto, A. A. do Egito, Fernando Baldi, Henner Simianer, Marcos Vinícius Gualberto Barbosa da Silva   +9 more
openalex   +1 more source