Results 61 to 70 of about 63,209 (242)

LMO7 Suppresses Tumor‐Associated Macrophage Phagocytosis of Tumor Cells Through Degradation of LRP1

Advanced Science, EarlyView.
LMO7 in tumor‐associated macrophages suppresses phagocytosis of tumor cells and limits cytotoxic T lymphocytes infiltration, fostering tumor progression. Mechanistically, LMO7 mediates the ubiquitination and degradation of the phagocytic receptor LRP1, impairing its ability to engulf tumor cells and driving macrophages toward an antitumor phenotype ...
Mengkai Li, Tao Wang, Yuwen Zhong, Zhiming Wang, Wei Li, Zejian Wang, Xinyi Yang, Yu Qiao, Jianfeng Xiang, Wei Gu, Zishu Wang, Lei Sun, Feng Qian   +12 more
wiley   +1 more source

Impact of diversity of Mycoplasma hyopneumoniae strains on lung lesions in slaughter pigs [PDF]

, 2017
The importance of diversity of Mycoplasma hyopneumoniae (M. hyopneumoniae) strains is not yet fully known. This study investigated the genetic diversity of M.
Arsenakis, Ioannis, Boyen, Filip, Del Pozo Sacristán, Rubén, Haesebrouck, Freddy, Maes, Dominiek, Michiels, Annelies, Piepers, Sofie, Vranckx, Katleen   +7 more
core   +2 more sources

Extracellular Vesicles of Streptococcus anginosus Mediate Gastritis via Epithelial Barrier Disruption and Macrophage‐driven Inflammation

Advanced Science, EarlyView.
Streptococcus anginosus extracellular vesicles (SA‐EVs) accumulate in gastric tissue, disrupt epithelial tight junctions, and induce gastritis characterized by neutrophil infiltration and elevated cytokines (TNF‐α, IL‐6, IL‐17A). Proteomics identifies TMPC and FBP62 as key SA‐EVs virulence factors; their genetic deletion attenuates inflammation ...
Ying Gong, Lina Duan, Jie Xiao, Yulu Deng, Hongxia Wang, Yajie Zhang, Xiumei Hu, Haifang Wang, Taixue An, Xin Li, Yurong Qiu, Lei Zheng, Haixia Li   +12 more
wiley   +1 more source

Particulate Matter Exposure Impairs Systemic Microvascular Endothelium-Dependent Dilation [PDF]

, 2004
Acute exposure to airborne pollutants, such as solid particulate matter (PM), increases the risk of cardiovascular dysfunction, but the mechanisms by which PM evokes systemic effects remain to be identified.
Barger, Mark, Boegehold, Matthew A., Castranova, Vincent, Nurkiewicz, Timothy R., Porter, Dale W.   +4 more
core   +3 more sources

Boron Nitride Nanomaterials Trigger Immunomodulatory Effects in Human Broncho‐Epithelial Cells by Modulating Eicosanoid Lipid Signaling

Advanced Science, EarlyView.
This study demonstrates that BNNT exposure disrupts lipid homeostasis in bronchial epithelial cell cultures and activates eicosanoid lipid biosynthesis, producing inflammatory lipid mediators like leukotrienes. These effects are more pronounced in asthmatic cell cultures compared to healthy ones.
Govind Gupta, Jonas Bossart, Sènan Mickael D'Almeida, Luis Augusto Visani de Luna, Christoph Schwärzler, Tingting Fu, Vanesa Ayala‐Nunez, Alexander Gogos, Marija Buljan, Vera M Kissling, Emmanuel Flahaut, Miguel Garcia, Cyrill Bussy, Peter Wick, Tina Buerki‐Thurnherr   +14 more
wiley   +1 more source

Serial bronchoscopic lung lavage in pulmonary alveolar proteinosis under local anesthesia

Lung India, 2015
Pulmonary alveolar proteinosis (PAP) is a rare disease, characterized by alveolar accumulation of surfactant composed of proteins and lipids due to defective surfactant clearance by alveolar macrophages.
K Rennis Davis, D Thomas Vadakkan, E V Krishnakumar, A Muhammed Anas   +3 more
doaj   +1 more source

Macrophage TRIM21 Inhibition Ameliorates Murine Acute Pancreatitis via PHB2‐Mediated Mitochondrial Stabilization

Advanced Science, EarlyView.
Macrophage‐derived TRIM21 drives the progression of AP via ubiquitin‐proteasome‐mediated degradation of PHB2, leading to impaired PHB2‐mediated mitophagy. Therefore, accumulation of cytosolic mtDNA hyperactivates the cGAS‐STING signaling axis, thereby amplifying inflammatory cascades.
Yansong Xu, Yuansong Sun, Xin Zhou, Kai Song, Chunlin Yin, Zhaohua Wang, Fei Xie, He Li   +7 more
wiley   +1 more source

A Hereditary Pulmonary Alveolar Proteinosis Caused by a Novel Hemizygous Variation of the CSF2RA Gene Case Report and Literature Review

Molecular Genetics & Genomic Medicine
Background Hereditary pulmonary alveolar proteinosis (PAP) is a rare interstitial lung disease caused by variations in genes such as CSF2RA and CSF2RB, which disrupt granulocyte‐macrophage colony‐stimulating factor signaling and impair surfactant ...
Qiang Chen, Sufen Zhang, Xiaomin Zhu, Yaru Zhu, Jinyang Chen, Hongjun Chen, Gefei Xiao   +6 more
doaj   +1 more source

Amelioration of bleomycin-induced lung fibrosis in hamsters by dietary supplementation with taurine and niacin: biochemical mechanisms. [PDF]

, 1994
Interstitial pulmonary fibrosis induced by intratracheal instillation of bleomycin (BL) involves an excess production of reactive oxygen species, unavailability of adequate levels of NAD and ATP to repair the injured pulmonary epithelium, and an ...
Chandler DB, Chien KR, Christner P, Clark JG, Counts DF, Crouch E, D M Hyde, Fukae M, Garnick MB, Giri SN, Giri SN, Karlinski JB, Kelley J, Koob TJ, Lowry OH, Marom Z, McQuaid A, Misra HP, Moss DW, Nakashima JM, Nakashima T, Phan SH, Q Wang, R B Rucker, R Blaisdell, Reiser KM, Riley DJ, S N Giri, Scherle WF, Snider GL, Thrall RS, Trush MA, Wang Q, Witschi HP, Zuckerman JE   +34 more
core   +2 more sources

Whole lung lavage.

Monaldi archives for chest disease = Archivio Monaldi per le malattie del torace, 1995
Bronchoalveolar lavage is universally employed as a diagnostic procedure and also, both in the massive (whole lung) and limited forms, has important therapeutic applications. Since the second half of the century whole lung lavage (WLL) has been applied in patients with pulmonary alveolar proteinosis and has proved successful. The procedure has improved
G. Rodi, IOTTI, GIORGIO ANTONIO, C. Galbusera, S. Mencherini, F. Raimondi, BRASCHI, ANTONIO   +5 more
openaire   +1 more source