Results 51 to 60 of about 345,506 (334)

Bringing Open Data to Whole Slide Imaging [PDF]

, 2019
Faced with the need to support a growing number of whole slide imaging (WSI) file formats, our team has extended a long-standing community file format (OME-TIFF) for use in digital pathology. The format makes use of the core TIFF specification to store multi-resolution (or "pyramidal") representations of a single slide in a flexible, performant manner.
Sébastien Besson, Roger Leigh, Melissa Linkert, Chris Allan, Jean-Marie Burel, Mark Carroll, David Gault, Riad Gozim, Simon Li, Dominik Lindner, Josh Moore, Will Moore, Petr Walczysko, Frances Wong, Jason R. Swedlow   +14 more
openaire   +3 more sources

A relationship between slide quality and image quality in whole slide imaging (WSI) [PDF]

Diagnostic Pathology, 2008
This study examined the effect of tissue section thickness and consistency--parameters outside the direct control of the imaging devices themselves--on WSI capture speed and image quality. Preliminary data indicates that thinner, more consistent tissue sectioning (such as those produced by automated tissue sectioning robots) results in significantly ...
Yagi, Yukako, Gilbertson, John R
openaire   +4 more sources

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Whole Slide Image Understanding in Pathology: What Is the Salient Scale of Analysis?

BioMedInformatics
Background: In recent years, there has been increasing research in the applications of Artificial Intelligence in the medical industry. Digital pathology has seen great success in introducing the use of technology in the digitisation and analysis of ...
Eleanor Jenkinson, Ognjen Arandjelović
doaj   +1 more source

ImageBox 2 – Efficient and rapid access of image tiles from whole-slide images using serverless HTTP range requests

Journal of Pathology Informatics, 2020
Background: Whole-slide images (WSI) are produced by a high-resolution scanning of pathology glass slides. There are a large number of whole-slide imaging scanners, and the resulting images are frequently larger than 100,000 × 100,000 pixels which ...
Erich Bremer, Joel Saltz, Jonas S Almeida   +2 more
doaj   +1 more source

Liver whole slide image analysis for 3D vessel reconstruction [PDF]

, 2015
The emergence of digital pathology has enabled numerous quantitative analyses of histopathology structures. However, most pathology image analyses are limited to two-dimensional datasets, resulting in substantial information loss and incomplete ...
Kong, J, Liang, Y, Magee, DR, Teodoro, G, Treanor, D, Wang, F, Zhu, Y   +6 more
core   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Artificial intelligence as a tool for diagnosis in digital pathology whole slide images: A systematic review

Journal of Pathology Informatics, 2022
Digital pathology had a recent growth, stimulated by the implementation of digital whole slide images (WSIs) in clinical practice, and the pathology field faces shortage of pathologists in the last few years.
João Pedro Mazuco Rodriguez, Rubens Rodriguez, Vitor Werneck Krauss Silva, Felipe Campos Kitamura, Gustavo Cesar Antônio Corradi, Ana Carolina Bertoletti de Marchi, Rafael Rieder   +6 more
doaj   +1 more source

Continuous representation of tumor microvessel density and detection of angiogenic hotspots in histological whole-slide images [PDF]

, 2015
Blood vessels in solid tumors are not randomly distributed, but are clustered in angiogenic hotspots. Tumor microvessel density (MVD) within these hotspots correlates with patient survival and is widely used both in diagnostic routine and in clinical ...
Kather, J. N., Marx, A., Reyes-Aldasoro, C. C., Schad, L. R., Weis, C. A., Zöllner, F. G.   +5 more
core   +1 more source

Monitoring of circulating tumor DNA allows early detection of disease relapse in patients with operable breast cancer

Molecular Oncology, EarlyView.
Monitoring circulating tumor DNA (ctDNA) in patients with operable breast cancer can reveal disease relapse earlier than radiology in a subset of patients. The failure to detect ctDNA in some patients with recurrent disease suggests that ctDNA could serve as a supplement to other monitoring approaches.
Kristin Løge Aanestad, Marie Austdal, Oddmund Nordgård, Gunnar Mellgren, Satu Oltedal, Marie L. Austbø, Ylva H. Vignes, Thomas Helland, Kristin Jonsdottir, Tone H. Lende, Emilius A. M. Janssen, Bjørnar Gilje, Kjersti Tjensvoll, PBCB study group, Gunnar Mellgren, Tone Hoel Lende, Anette Heie, Kristin Viste, Anita Røyneberg Alvheim, Emiel AM Janssen, Kristin Jonsdottir, Ann Cathrine Kroksveen, Thomas Helland, Einar Gudlaugsson, Oddmund Nordgård, Satu Oltedal, Kristin Løge Aanestad, Jan Terje Kvaløy, Kirsten Lode, Kari Britt Hagen, Marie Austdal, Ylva H. Vignes, Siri Tungland Sola, Nina Egeland Amundsen, Finn Magnus Eliassen, Emeritus Ernst A Lien   +35 more
wiley   +1 more source