Results 141 to 150 of about 16,279,971 (280)
Molecular Oncology, EarlyView.This study used longitudinal transcriptomics and gene‐pattern classification to uncover patient‐specific mechanisms of chemotherapy resistance in breast cancer. Findings reveal preexisting drug‐tolerant states in primary tumors and diverse gene rewiring patterns across patients, converging on a few dysregulated functional modules. Despite receiving the
Maya Dadiani +14 more
wiley +1 more source
Ubiquitination of transcription factors in cancer: unveiling therapeutic potential
Molecular Oncology, EarlyView.In cancer, dysregulated ubiquitination of transcription factors contributes to the uncontrolled growth and survival characteristics of tumors. Tumor suppressors are degraded by aberrant ubiquitination, or oncogenic transcription factors gain stability through ubiquitination, thereby promoting tumorigenesis.
Dongha Kim, Hye Jin Nam, Sung Hee Baek
wiley +1 more source
Power of genome-wide linkage disequilibrium testing by using microsatellite markers [PDF]
, 2003 Jun Ohashi, Katsushi Tokunaga
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Targeted protein degradation in oncology: novel therapeutic opportunity for solid tumours?
Molecular Oncology, EarlyView.Current anticancer therapies are limited by the occurrence of resistance and undruggability of most proteins. Targeted protein degraders are novel, promising agents that trigger the selective degradation of previously undruggable proteins through the recruitment of the ubiquitin–proteasome machinery. Their mechanism of action raises exciting challenges,
Noé Herbel, Sophie Postel‐Vinay
wiley +1 more source
Do Test and Environmental Complexity Increase Flakiness? An Empirical Study of SAP HANA [PDF]
arXivBackground: Test flakiness is a major problem in the software industry. Flaky tests fail seemingly at random without changes to the code and thus impede continuous integration (CI). Some researchers argue that all tests can be considered flaky and that tests only differ in their frequency of flaky failures.
arxiv
IS DRIED BLOOD AS RELIABLE AS FRESH SERUM IN MAKING THE WIDAL TEST?
, 1914 G. F. Ruediger, R. Hulbert
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FEBS Open Bio, EarlyView.This review highlights how foundation models enhance predictive healthcare by integrating advanced digital twin modeling with multiomics and biomedical data. This approach supports disease management, risk assessment, and personalized medicine, with the goal of optimizing health outcomes through adaptive, interpretable digital simulations, accessible ...
Sakhaa Alsaedi +2 more
wiley +1 more source
Description of the digital analysis programs used to analyze the wide band test data
, 1965 A.H. Killinger +3 more
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Adaptive advantages of myrmecochory: the predator‐avoidance hypothesis tested over a wide geographic range [PDF]
, 2005 Antonio J. Manzaneda +2 more
openalex +1 more source
Red blood cells could protect miRNAs from degradation or loss thanks to Argonaute 2 binding
FEBS Open Bio, EarlyView.The present work investigates the presence and the stability of miRNAs into RBCs, both native and engineered. The observed stability is due to the Ago2 bound resulting in minimal RISC. Indeed, if the miRNA‐Ago2 complex is present, miRNAs are protected from release or degradation and they are biologically active. Thus, RBCs can act as miRNA carriers for
Elena Perla +4 more
wiley +1 more source