Outcome parameters in studies investigating dry eye disease: A systematic literature review
Abstract The development of effective therapeutics for dry eye disease (DED) is challenging due to its complex pathophysiology, heterogeneous patient presentation and the significant failure rate of previous clinical development programs. This underlines the importance of the selection of appropriate endpoints for clinical trials.
Viktoria Pai +8 more
wiley +1 more source
Correction to: Diagnosis and treatment of iron deficiency in chronic heart failure. [PDF]
Messner M +16 more
europepmc +1 more source
Alpha‐1 antitrypsin deficiency is a genetic disease that affects the lungs and the liver. The role of the heterozygous genetic defect in the development of liver cancer in patients with cirrhosis is unclear. Our study found that carrying the Pi*MZ genotype increases the risk of developing liver cancer.
Lorenz Balcar +18 more
wiley +1 more source
Modified spinopelvic crab-shaped fixation using offset connectors for a H-shaped sacral fracture with a floating Roy-Camille type 3 transverse component: a case report. [PDF]
Okuda A +8 more
europepmc +1 more source
ABSTRACT This paper examines transport amphorae of Greek/Aegean types from the 7th–4th c. BCE imported to the Phoenician coastal settlement of Tell el‐Burak, Lebanon. We present a selection of 58 pieces analyzed by typological, chemical (NAA), and petrographic approaches.
Maximilian Rönnberg +3 more
wiley +1 more source
Wider window, easier access: optimizing Leksell Vantage positioning for posterior fossa stereotactic biopsy. [PDF]
Barbesino C +5 more
europepmc +1 more source
Demystifying the mist: Why do individuals hesitate to accept AI educational services?
Abstract Rapid advances in AI technology are fuelling the proliferation of AI applications across industries, including educational services. With the allure of intelligent tutoring, individuals now face the choice of their educational approach—either parental engagement or utilizing AI educational services. This research employs an experimental design
Aiping Shao +4 more
wiley +1 more source
Shunt surgery and lecanemab therapy in patients with idiopathic normal pressure hydrocephalus and alzheimer's disease: a report of two cases. [PDF]
Miyazaki K, Morita H, Ishii K.
europepmc +1 more source
Exploring dietary adaptations in Ursus minimus: a 3D geometric morphometric analysis of the mandible
Using 3D geometric morphometrics, the dietary adaptations of the extinct Auvergne bear (Ursus minimus) are analysed. Its mandibular morphology aligns more closely with omnivorous rather than insectivorous bears, challenging current ideas. The extinct bear Ursus minimus, which lived in Europe during the Pliocene and possibly Early Pleistocene, is ...
Anneke H. van Heteren
wiley +1 more source

