Results 181 to 190 of about 1,122,452 (311)

A Depolarizing Leak in Sodium Bicarbonate Cotransporter NBCe1 Causes Brain Edema

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives SLC4A4 encodes electrogenic sodium bicarbonate cotransporter NBCe1, prominently expressed in kidney and brain. Recessive loss‐of‐function variants in SLC4A4 cause proximal renal tubular acidosis, no brain edema. In the brain, NBCe1 is expressed by astrocytes, where it regulates pH and mediates astrocyte volume changes.
Quinty Bisseling, Mark D. Parker, Sven Kerst, Richard A. Pasternack, Jacob Tondreau, Marjolein Breur, Gemma M. van Rooijen‐van Leeuwen, Davide Tonduti, Ettore Salsano, Alejandra Darling, Joanna A. E. van Wijk, Susanna Törnroth‐Horsefield, Marianna Bugiani, Petra J. W. Pouwels, Quinten Waisfisz, Marjo S. van der Knaap, Rogier Min   +16 more
wiley   +1 more source

Sweat the small stuff: A review of the use of accelerometers to estimate energy expenditure in wild animals. [PDF]

J Anim Ecol
Elliott KH.
europepmc   +1 more source

An Update on Gastrointestinal Parasitic Infection in Captive Wild Animals in Bangladesh. [PDF]

J Parasitol Res, 2023
Rahman R, Nyema J, Imranuzzaman M, Banik B, Pranto PS, Talukder K, Sarkar SR, Nath SD, Islam KM, Nath TC, Islam S.   +10 more
europepmc   +1 more source

Unraveling 4‐Phenylbutyrate's Therapeutic Role in SLC6A1 Disorders: Pharmacochaperoning Over HDAC Inhibition

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Variants in SLC6A1, encoding the GABA transporter 1 (GAT‐1), cause epilepsy, autism spectrum disorder, and developmental delay via loss of GABA uptake, impaired trafficking, and ER retention. We previously found that 4‐Phenylbutyrate (PBA), an FDA‐approved drug, restores GABA uptake and reduces seizures in SLC6A1‐related disorders ...
Melissa B. DeLeeuw, Karishma Randhave, Ekta Anand, Ziang (Debbie) Song, Wangzhen Shen, Jing‐Qiong Kang   +5 more
wiley   +1 more source

Global seroprevalence and distribution of Getah virus in domestic and wild animals: A systematic review and meta-analysis. [PDF]

Vet World
Irekeola AA, Shueb RH.
europepmc   +1 more source

Cognitive and Neuroimaging Divergence Between Juvenile and Adult FUS Amyotrophic Lateral Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder characterized by progressive motor neuron degeneration. Fused in sarcoma (FUS)‐associated juvenile ALS (jALS) represents a distinct and aggressive subgroup with rapid deterioration and poor prognosis.
Alexandra V. Jürs, Marcel Naumann, Annaliis Lehto, Hanna Schön, Jens Kurth, Johannes Prudlo, Andreas Hermann, Elisabeth Kasper   +7 more
wiley   +1 more source

Myelolipomas in exotic pets, research, zoo, and wild animals: description of 52 cases and literature review. [PDF]

J Vet Diagn Invest
Ford AK, Villaseñor A, Newman SJ, Craig LE, Asin J, Streitenberger N, Mete A, Cornish T, Gonzalez O, Shivanna V, Perry DL, Dick EJ, Stranahan LW, Ubiali DG, Pescador CA, Negrão Watanabe TT, Graham EA, Barrantes Murillo DF.   +17 more
europepmc   +1 more source

Mechanoluminescent HOF Nanotransducers Enabled Sono‐Optogenetics in Parkinsonian Rats

Advanced Functional Materials, EarlyView.
We present a mechanoluminescent system utilizing porous hydrogen‐bonded organic frameworks (HOFs) as a toolkit for focused ultrasound‐triggered, non‐invasive light delivery to the deep brain in rats. This approach enables the specific activation of PV‐GPe neurons in dopamine‐depleted Parkinson's disease rat models, resulting in a comparable alleviation
Wenliang Wang, Ilya Pyatnitskiy, Yanshu Shi, Kai Wing Kevin Tang, Yi Xie, Sihan Yu, Thomas Wynn, Xiangping Liu, Ju‐Chun Hsieh, Jinmo Jeong, Weilong He, Brinkley Artman, Anakaren Romero Lozano, Xi Shi, Arjun Sangani, Lief E Fenno, Samantha Santacruz, Banglin Chen, Huiliang Wang   +18 more
wiley   +1 more source

Molecular identification of <i>Borrelia</i> and <i>Rickettsia</i> in hard ticks infesting domestic and wild animals in Cameroon. [PDF]

Parasite Epidemiol Control
Paguem A, Kamtsap P, Manchang KT, Renz A, Schaper S, Dobler G, Rollins RE, Chitimia-Dobler L.   +7 more
europepmc   +1 more source

Multimodal Perception and Machine Learning‐Empowered Human Machine Interfaces With Double‐Network Hydrogel Fibers

Advanced Functional Materials, EarlyView.
This work develops polyacrylamide‐alginate (PAM‐Alg) double‐network hydrogel fibers for multimodal perception and intelligent human‐machine interfaces. The covalent‐ionic network provides high strength, toughness, and stable conductivity. Easily woven into wearables and integrated with soft robots, the fibers enable object and temperature recognitions ...
Yujue Yang, Minyu Qiu, Di Tan, Xinlong Liu, Junze Zhang, Ziyu He, Jing Han, Yuanyuan Gao, Zihua Li, Hong Fu, Bingang Xu   +10 more
wiley   +1 more source