Bush Animal Attacks: Management of Complex Injuries in a Resource-Limited Setting. [PDF]
Though animal-related injuries and fatalities have been documented throughout the world, the variety of attacks by wild animals native to rural East Africa are less commonly described.
Kotecha Vihar R +5 more
core +1 more source
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
Animal Behavior: Timing in the Wild [PDF]
A recent study has found that Rufous hummingbirds time the interval between successive visits to flowers that replenish at different rates. The hummingbirds have been shown to store information about both where and when they ate throughout the day, evidence that this species has two components of episodic memory.
openaire +2 more sources
Structure‐forward targeting of claudins with synthetic binders
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
A Ten-Stage Protocol for Assessing the Welfare of Individual Non-Captive Wild Animals: Free-Roaming Horses (Equus Ferus Caballus) as an Example [PDF]
Knowledge of the welfare status of wild animals is vital for informing debates about the ways in which we interact with wild animals and their habitats.
Andrea M. Harvey +7 more
core +1 more source
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
Wild, but not too-wild animals [PDF]
Rewilding is positioned as ‘post'-conservation through its emphasis on unleashing the autonomy of natural processes. In this paper, we argue that the autonomy of nature rhetoric in rewilding is challenged by human interventions. Instead of joining critique toward the ‘managed wilderness' approach of rewilding, however, we examine the injustices this ...
Von Essen, Erica, Allen, Michael P.
openaire
Tuberculosis in Captive Wild Animals [PDF]
The results of this investigation show that tuberculosis in captive wild mammals may be caused by any one of the three types of tubercle bacilli—human, bovine or avian.In the Primates, which under experimental conditions are susceptible in an equal degree to bovine and human tubercle bacilli, natural tuberculosis may result from infection with either ...
openaire +2 more sources

