Results 91 to 100 of about 2,262,131 (334)

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Acute sleep disruption- and high-fat diet-induced hypothalamic inflammation are not related to glucose tolerance in mice

Neurobiology of Sleep and Circadian Rhythms, 2018
Chronic insufficient sleep is a major societal problem and is associated with increased risk of metabolic disease. Hypothalamic inflammation contributes to hyperphagia and weight gain in diet-induced obesity, but insufficient sleep-induced ...
Jacqueline M. Ho, Nicole H. Ducich, Nhat-Quynh K. Nguyen, Mark R. Opp   +3 more
doaj   +1 more source

One thousand good things in Nature: aspects of nearby Nature associated with improved connection to Nature [PDF]

, 2015
As our interactions with nature occur increasingly within urban landscapes, there is a need to consider how ‘mundane nature’ can be valued as a route for people to connect to nature.
Hallam, Jenny, Lumber, Ryan, Richardson, Miles   +2 more
core   +2 more sources

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Effect of active external rewarming on esophageal temperature in simulated prehospital accidental hypothermia: a randomized crossover trial

Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine
Background Prehospital rewarming is crucial to reduce mortality and improve outcomes in patients with accidental hypothermia. Although international guidelines recommend combining active external rewarming with passive rewarming, the effect of active ...
Sigurd Mydske, Ane Marthe Helland, Nicola Borasio, Guttorm Brattebø, Øyvind Østerås, Øystein Wiggen, Jörg Aßmus, Giacomo Strapazzon, Øyvind Thomassen   +8 more
doaj   +1 more source

Enhancing Military Medical Education: A Pilot Study Integrating Kolb’s Experiential Learning and Diversified Teaching Strategies to Elevate Undergraduate Medical Student Learning Effectiveness

Journal of Medical Sciences
Background: The increasing frequency of natural disasters, pandemics, and geopolitical conflicts highlights the importance of military and disaster medicine.
Yu-Chin An, Che-Yu Guan, Hung-Kai Shih, Yi-Da Tsai, Shih-Hung Tsai, Wen-I Liao   +5 more
doaj   +1 more source

Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib

Molecular Oncology, EarlyView.
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute, Júlia Huguet‐Pradell, Jordi Abril‐Fornaguera, Albert Gris‐Oliver, Alex Rialdi, Elisa Fernández‐Martínez, Carla Montironi, Vanessa Del Pozo, Peter Houghton, Laura Zanatto, Agavni Mesropian, Ieva Keraite, Swan Thung, Carolina Armengol, Pau Sancho‐Bru, Ernesto Guccione, Roser Pinyol, Josep M. Llovet   +17 more
wiley   +1 more source

Haematological and serum biochemical reference values in free-ranging red deer (Cervus elaphus atlanticus)

Rangifer, 2004
Analyses of haematological and biochemical constituents were carried out on the Norwegian subspecies of free-ranging red deer (Cervus elaphus atlanticus).
Olav Rosef, Håvard L. Nystøyl, Tore Solenes, Jon M. Arnemo   +3 more
doaj   +1 more source

What is the place of democracy in recreation ecology? [PDF]

, 2008
What should be monitored and who decides has been debated for as long as recreation ecology has been with us. The early work on planning frameworks advocates consulting with visitors to determine what conditions are important to them and then derive ...
Moore, S.A.
core   +1 more source