Results 91 to 100 of about 3,711 (250)

Introduction to Wilderness Medicine-A Medical School Elective. [PDF]

J Educ Teach Emerg Med, 2020
Pittman MA, Slone T, Wilson M.
europepmc   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

High Tech POCUS Education in Remote Environments: An App Review

POCUS Journal, 2023
Jeremy Webb, Chad Mosby, John Stadnyk, Michael Jones   +3 more
doaj   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

From snared to swimming: Some observations on the rescue, treatment, release and monitoring of an injured Sri Lankan leopard (Panthera pardus kotiya)

Ecological Solutions and Evidence
The Sri Lankan leopard (Panthera pardus kotiya) is a threatened endemic sub‐species and the island's apex predator. Wire snares represent a substantial threat to leopards here, with conservation officials routinely rescuing snared leopards.
Andrew Marten Kittle, Anjali Chandraraj Watson, Tharaka Prasad, Manoj Akalanka Pinidiya, Arachchi Mudiyanselage Kasun Nilupa Kumarasiri, Madanperuma Arachchillage Priyantha Rohana Kumara, Weerasinha Mudiyanselage Nilantha Kumara Weerasinha, Gajanayaka M. Vidura, Luwisdura Neville Adrick deSilva, Dona Daphney Niranjala deSilva, Kalaichelvan Nizanantha, Hewapthiranage Dhanushka Sayani Hewapathirana   +11 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Case Report: Synovial chondromatosis in sport climbers fingers

Frontiers in Sports and Active Living
IntroductionSport Climbing is a rapidly developing sport with an increasing variety and number of injuries, especially now that it is an Olympic event. The objective of this study is to firstly report the presence of Finger Synovial Chondromatosis (FSC ...
Helmut Becker, Xeber Iruretagoiena-Urbieta, Xeber Iruretagoiena-Urbieta, Xeber Iruretagoiena-Urbieta, Volker Schöffl, Volker Schöffl, Volker Schöffl, Volker Schöffl, Volker Schöffl   +8 more
doaj   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Proposal of a specific classification of primary periphyseal stress injuries in adolescent rock climbers

Frontiers in Sports and Active Living
IntroductionPrimary Periphyseal Stress Injuries (PPSI) of the hand and fingers are relatively uncommon but are most frequently seen in adolescent rock climbers.
V. Schöffl, V. Schöffl, V. Schöffl, V. Schöffl, V. Schöffl, X. Iruretagoiena, T. Nelson, Paulo Miro   +7 more
doaj   +1 more source