Results 61 to 70 of about 3,711 (250)

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Effect of active external rewarming on esophageal temperature in simulated prehospital accidental hypothermia: a randomized crossover trial

Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine
Background Prehospital rewarming is crucial to reduce mortality and improve outcomes in patients with accidental hypothermia. Although international guidelines recommend combining active external rewarming with passive rewarming, the effect of active ...
Sigurd Mydske, Ane Marthe Helland, Nicola Borasio, Guttorm Brattebø, Øyvind Østerås, Øystein Wiggen, Jörg Aßmus, Giacomo Strapazzon, Øyvind Thomassen   +8 more
doaj   +1 more source

Strikes and stripes of the Saw-scaled Viper in the Western Ghats-A case series

Toxicology Reports
We describe 5 cases of envenomation and complications related to saw scaled viper (Echis carinatus) bites from the Western Ghats region of Karnataka over a period of 5 years (December 2019-May 2023).
Vrinda Lath, Dimple Shekhawat, Freston Marc Sirur   +2 more
doaj   +1 more source

Acute sleep disruption- and high-fat diet-induced hypothalamic inflammation are not related to glucose tolerance in mice

Neurobiology of Sleep and Circadian Rhythms, 2018
Chronic insufficient sleep is a major societal problem and is associated with increased risk of metabolic disease. Hypothalamic inflammation contributes to hyperphagia and weight gain in diet-induced obesity, but insufficient sleep-induced ...
Jacqueline M. Ho, Nicole H. Ducich, Nhat-Quynh K. Nguyen, Mark R. Opp   +3 more
doaj   +1 more source

Wilderness Medicine Curricula in United States EMS Fellowship, Emergency Medicine Residency, and Wilderness Medicine Programs. [PDF]

Prehosp Disaster Med, 2022
Holstrom-Mercader M, Kass D, Corsetti M, Flamm A.   +3 more
europepmc   +1 more source

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

Molecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann, Eduardo García‐Galea, Alice O'Farrell, Zak Kinsella, Maxime Meylan, Florent Petitprez, Ingrid Arijs, Tom Venken, Hari Ps, Adrian Lärkeryd, Ian Miller, Janick Selves, Nadja Meindl‐Beinker, Fiorella Ruiz‐Pace, Elena Élez, Raquel Comas‐Navarro, Frank Lincoln, Dirk Fey, Gift Nyamundanda, Aoife Nolan, Joern Lewin, Raquel Perez‐Lopez, Jonathan Briody, Kathleen Bennett, Walter Kolch, David Matallanas, Alexander Kel, Enrique Arenas, Joaquín Arribas, Bart Ghesquière, Josep Tabernero, Julie Meilleroux, Deborah McNamara, Ray McDermott, Marvin Lim, Mary O'Reilly, Brian Bird, Lisa Stack, Lucia Moloney, Patrick Morris, Keith Egan, Maciej Milewski, Lars Scheuer, Joachim Behringer, Georg Bolz, Ramon Salazar, Cristina Santos, Andrea Ruiz, Orla Casey, Verena Murphy, Matthias Ebert, Livio Trusolino, Diether Lambrechts, Anguraj Sadanandam, Catherine Sautès‐Fridman, Jochen Prehn, Paolo Nuciforo, Jacques Fieschi, Florence Monville, Darran O'Connor, Wolf Fridman, Annette Byrne   +61 more
wiley   +1 more source

Everyday Water-Related Emergencies: A Didactic Course Expanding Wilderness Medicine Education. [PDF]

J Educ Teach Emerg Med, 2023
Comp GB, Burmood E, Enenbach M, Seigneur S.   +3 more
europepmc   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Novel drugs in the management of acute mountain sickness and high altitude pulmonary edema

Open Access Journal of Sports Medicine, 2015
Gaurav Sikri, Anirban Bhattacharya Department of Physiology, Armed Forces Medical College, Wanowarie, Pune, IndiaWe read with great interest the review article titled “Wilderness medicine at high altitude: recent developments in the field” by
Sikri G, Bhattacharya A
doaj  

Enhancing Military Medical Education: A Pilot Study Integrating Kolb’s Experiential Learning and Diversified Teaching Strategies to Elevate Undergraduate Medical Student Learning Effectiveness

Journal of Medical Sciences
Background: The increasing frequency of natural disasters, pandemics, and geopolitical conflicts highlights the importance of military and disaster medicine.
Yu-Chin An, Che-Yu Guan, Hung-Kai Shih, Yi-Da Tsai, Shih-Hung Tsai, Wen-I Liao   +5 more
doaj   +1 more source