Results 41 to 50 of about 29,311 (229)

Adhesion molecules in Wilms tumor (part II) : beta-catenin expression and significance [PDF]

Srpski Arhiv za Celokupno Lekarstvo, 2003
Beta-catenin is a glicoprotein which has an important role in cell-cell adhesion, as well as in cell signal transmition, in u regulation of gen expression and in interaction with axin and APC (adenomatous poliposis coli).
Basta-Jovanović Gordana M., Radojević Sanja M., Đuričić Slaviša M., Savin Marina, Škodrić Stevo, Bunjevački Gordana, Hadži-Đokić Jovan B., Nešić Vidosava B.   +7 more
doaj   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

m6A‐Mediated Glycolysis by IL‐37 Drives T Cell Metabolic Reprogramming to Regulate Colitis

Advanced Science, EarlyView.
This study identifies an IL‐37/SIGIRR‐METTL14 regulatory axis that suppresses global m6A modification in CD4+ T cells. IL‐37 signaling, mediated through SIGIRR, inhibits IRAK4 and JNK phosphorylation, leading to downregulation of the methyltransferase METTL14.
Xiaoyan Wang, Jiadong Yu, Guolin Li, Ya Li, Fanlian Zeng, Jing Hu, Yifan Zhou, Chengcheng Yue, Qixiang Zhao, Chen Zhang, Hong Zhou, Fulei Zhao, Yawen Hu, Pei Zhou, Linna Gu, Yuting Feng, Mingxiang He, Shishi Huang, Xiaochi Sun, Xinmeng Wang, Jie Tang, Xinyu Zeng, Wenling Wu, Nongyu Huang, Xinai Cui, Kaijun Cui, Jiong Li   +26 more
wiley   +1 more source

A big Wilms tumor in a 14-months-old boy

Journal of Education, Health and Sport, 2019
Introduction. Wilms tumor (nephroblastoma) is a malignant neoplasm located in a kidney. It is typical for children and it occurs almost exclusively in a childhood. Purpose of work, material and methods. The aim of the study is presentation of symptoms,
Agnieszka Wójtowicz, Robert Ściślak, Karolina Widłak, Joanna Nurzyńska-Flak   +3 more
doaj   +3 more sources

DNA Methylation Data-Based Classification and Identification of Prognostic Signature of Children With Wilms Tumor

Frontiers in Cell and Developmental Biology, 2021
Background: As an epigenetic alteration, DNA methylation plays an important role in early Wilms tumorigenesis and is possibly used as marker to improve the diagnosis and classification of tumor heterogeneity.Methods: Methylation data, RNA-sequencing (RNA-
Fucai Tang, Zeguang Lu, Hanqi Lei, Hanqi Lei, Yongchang Lai, Zechao Lu, Zhibiao Li, Zhicheng Tang, Jiahao Zhang, Zhaohui He   +9 more
doaj   +1 more source

WTAP‐Mediated m6A Modification Targets the LRP1‐Lipid Metabolism Axis to Regulate Joint Cartilage Regeneration

Advanced Science, EarlyView.
WTAP drives cartilage regeneration by activating an LRP1‐dependent lipid metabolic program in macrophages, enhancing IL‐10 and TGF‐β secretion to promote chondrogenic differentiation. Leveraging this mechanism, virtual screening identifies LRP1‐targeting compounds that effectively stimulate cartilage repair, highlighting a druggable epigenetic ...
Chenyan Huang, Chenyu Deng, Zhengrong Gao, Chen Chen, Huimin Zheng, Yue Yang, Yan Wei   +6 more
wiley   +1 more source

High‐Resolution Genomic Characterization of WAGR Spectrum Disorder: Insights From a Novel Cohort and Literature Synthesis, and Validation of Patient‐Reported Data

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT WAGR spectrum disorder (WAGRSD) is an ultra‐rare congenital disorder caused by heterozygous deletion of chromosome 11p13. While classically associated with Wilms tumor, Aniridia, Genitourinary anomalies, and a Range of developmental delays, accurate delineation of the deletion is critical for prognosis because the phenotypic spectrum extends ...
Andrew M. George, Bamelak T. Duki, Zoe S. Katz, Aravind Viswanathan, Suzanne P. MacFarland, Evan R. Hathaway, Caitlin Monahan, John Morris, Kelly L. Trout, Shari M. Krantz, Arupa Ganguly, Jennifer M. Kalish   +11 more
wiley   +1 more source

LOSS OF HETEROZYGOSITY ANALYSIS AT DIFFERENT CHROMOSOME REGIONS IN WILMS TUMOR CONFIRMS 1P ALLELIC LOSS AS A MARKER OF WORSE PROGNOSIS: A STUDY FROM THE ITALIAN ASSOCIATION OF PEDIATRIC HEMATOLOGY AND ONCOLOGY

, 2013
PURPOSE: The specific aims of the AIEOP-TW-2003 protocol included prospectively investigating a possible association of tumor loss of heterozygosity with outcomes in children treated for Wilms tumor.
Nantron M, AIEOP Wilms Tumor Working Group, PESSION, ANDREA, D'Angelo P, Indolfi P, Morosi C, Radice P, Di Cataldo A, Mariani L, Terenziani M, Perotti D, Gamba B, Collini P, Spreafico F   +13 more
core   +1 more source

Integrative Transcriptomic Profiling of the Wilms Tumor

, 2023
Our study aimed to identify relevant transcriptomic biomarkers for the Wilms tumor, the most common pediatric kidney cancer, independent of the histological type and stage.
Robert Kordič, Maruša Debeljak, Robert Šket, Olga Blatnik, Tine Tesovnik, Simona Lucija Avčin, Janez Jazbec, Klementina Črepinšek, Blaž Vrhovšek, Jerca Blazina, Jernej Kovač, Lidija Kitanovski, Barbara Jenko Bizjan   +12 more
core   +1 more source

Nephron-sparing surgery for Wilms tumor [PDF]

, 2023
The algorithm that has been used successfully in the surgical management of unilateral Wilms tumor, radical nephroureterectomy, cannot be used in children who present with synchronous bilateral renal masses.
Andrew J. Murphy, Andrew M. Davidoff
core   +1 more source