Pediatric Blood & Cancer, 2020 AbstractThe objectives for the treatment of Wilms tumor in both the Children's Oncology Group (COG) and the International Society of Paediatric Oncology (SIOP) have focused on improving cure rates and minimizing toxicity by limiting the use of radiation and doxorubicin.
Luke Pater +6 more
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Teratoid Wilms Tumor: Report of Three Cases and Review of the Literature
Türk Patoloji Dergisi, 2019 Teratoid Wilms tumor is a rare variant of Wilms tumor composed predominantly of well-differentiated epithelial and/or mesenchymal heterologous elements. Like the classical Wilms tumor, this variant may also occur as a renal mass or may be found in extra ...
Doaa AL GHAMDI +2 more
doaj +2 more sources
Suppressing proteasome activity enhances sensitivity to actinomycin D in diffuse anaplastic Wilms tumor [PDF]
Cell Reports MedicineSummary: Wilms tumor is the most common pediatric kidney cancer, and diffuse anaplastic Wilms tumor is the most chemoresistant subtype. Here, we explore how Wilms tumor cells evade the chemotherapy actinomycin D, which inhibits ribosomal RNA biogenesis ...
Patricia D.B. Tiburcio +3 more
doaj +2 more sources
Wilms tumor: "State-of-the-art" update, 2016 [PDF]
Seminars in Pediatric Surgery, 2016 Despite an impressive increase in survival rate over the past decades, there is still a need to improve the survival of specific subgroups of Wilms tumor (anaplastic, metastatic, and bilateral) and to decrease the late effects of treatment in terms of ...
Ehrlich, PF +2 more
core +2 more sources
Distinct pathways for genetic and epigenetic predisposition in familial and bilateral Wilms tumor [PDF]
Genome MedicineBackground Genetic predisposition is particularly common in children with the kidney cancer, Wilms tumor. In 10% of these children, this manifests as a family history of Wilms tumor or bilateral disease.
Jenny Wegert +31 more
doaj +2 more sources
Advances in Pediatrics, 2006 Significant improvement has been made in the treatment of children with Wilms tumor. New protocols are in place designed to maintain a high rate of cure for these patients while minimizing toxicity, based on refinement of the risk-stratification system.
F, Seseke, P, Gutjahr, B, Kremens
openaire +6 more sources
Morphoproteomic profiling of the mammalian target of rapamycin (mTOR) signaling pathway in desmoplastic small round cell tumor (EWS/WT1), Ewing's sarcoma (EWS/FLI1) and Wilms' tumor(WT1). [PDF]
, 2013 BackgroundDesmoplastic small round cell tumor (DSRCT) is a rare sarcoma in adolescents and young adults. The hallmark of this disease is a EWS-WT1 translocation resulting from apposition of the Ewing's sarcoma (EWS) gene with the Wilms' tumor (WT1) gene.
Anderson, Pete M +6 more
core +15 more sources
Knockdown of SENP1 inhibits HIF-1α SUMOylation and suppresses oncogenic CCNE1 in Wilms tumor
Molecular Therapy: Oncolytics, 2021 Based on our initial bioinformatics finding of the upregulated expression of sentrin-specific protease 1 (SENP1) and cyclin E1 (CCNE1) in Wilms tumor, this study aimed to illustrate the molecular mechanism of SENP1 in Wilms tumor, which involved the ...
Shibo Zhu +6 more
doaj +1 more source
Prognostic Factors for Wilms Tumor Recurrence: A Review of the Literature
Cancers, 2021 Simple Summary A Wilms tumor is a childhood kidney tumor. In high-income countries, 90% of patients with this tumor survive. However, the tumor recurs in 15% of patients.
Alissa Groenendijk +13 more
semanticscholar +1 more source
Research advances in the targeted therapy and immunotherapy of Wilms tumor: a narrative review
Translational Cancer Research, 2021 Wilms tumor is the most common pediatric abdominal solid tumor, and its treatment has been a focus of research. For now, the 5-year survival rate of children with Wilms tumor is about 90%.
Boi-Lam Hong, Rui Dong
semanticscholar +1 more source