Results 41 to 50 of about 201 (140)

Integrative Multi‐Omics Analysis Reveals Convergent Epigenome and Transcriptome Changes in Parkinson's Disease

Movement Disorders, EarlyView.
Abstract Background The mechanisms that predispose dopaminergic neurons (DAN) to degeneration in Parkinson's disease (PD) are incompletely understood. Objective To perform an integrative multi‐omics reanalysis of single‐cell transcriptomic and epigenomic data to identify convergent alterations predisposing dopaminergic neurons to degeneration in ...
Mirco Macchi, Aurélien Ginolhac, Tony Heurtaux, Borja Gomez‐Ramos, Lasse Sinkkonen, Enrico Glaab, on behalf of the NCER‐PD Consortium, Mariella Graziano, Alexandre Bisdorff, Rene Dondelinger, Elodie Thiry, Gelani Zelimkhanov, Guy Berchem, Liliana Vilas Boas, Linda Hansen, Martine Goergen, Nancy De Bremaeker, Nico Diederich, Romain Nati, Roxane Batutu, Sylvia Herbrink, Jochen Klucken, Rejko Krüger, Claire Pauly, Lukas Pavelka, Marijus Giraitis, Maria Fernanda Niño Uribe, Achilleas Pexaras, Alexander Hundt, Alexia Mendibide, Ana Festas Lopes, Angelo Ferrari, Brian Dewitt, Carlos Gamio, Estelle Henry, Gaël Hamot, Geeta Acharya, Hermann Thien, Ilsé Richard, Johanna Trouet, Kate Sokolowska, Katy Beaumont, Laura Georges, Lorieza Castillo, Lucie Remark, Maeva Munsch, Margaux Henry, Maud Theresine, Olga Kofanova, Olivia Roland, Pauline Lambert, Saïda Mtimet, Wim Ammerlaan, Anne Grünewald, Armin Rauschenberger, Clarissa P.C. Gomes, Dheeraj Reddy Bobbili, Ekaterina Soboleva, Elisa Gómez de Lope, Enrico Glaab, Evi Wollscheid‐Lengeling, Francoise Meisch, Giuseppe Arena, Ibrahim Boussaad, Iñigo Yoldi Bergua, Jens Schwamborn, Kirsten Roomp, Laure Pauly, Michael T. Heneka, Michele Bassis, Muhammad Ali, Jade Jaber, Patricia Martins Conde, Patrick May, Paul Wilmes, Piotr Gawron, Rebecca Ting Jiin Loo, Reinhard Schneider, Ruxandra Soare, Sabine Schmitz, Sarah Nickels, Sascha Herzinger, Sinthuja Pachchek, Soumyabrata Ghosh, Stefano Sapienza, Valentin Groues, Venkata Satagopam, Isabel Schwaninger, Liyousew Borga, Sijmen Van Schagen, Gabriel Martinez Tirado, Alan Castro Mejia, Messaline Fomo, Niloofar Kheradbin, Francesca Boschi, Francesca Terranova, Jochen Ohnmacht, Anne‐Marie Hanff, Carlos Vega, Chouaib Mediouni, Deborah Mcintyre, Eduardo Rosales, Fozia Noor, Gessica Contesotto, Gloria Aguayo, Guilherme Marques, Jérôme Graas, Joëlle Fritz, Magali Perquin, Manon Gantenbein, Maura Minelli, Michel Vaillant, Myriam Alexandre, Myriam Menster, Olena Tsurkalenko, Raquel Severino, Sibylle Béchet, Tainá M. Marques, Ulf Nehrbass, Victoria Lorentz, Zied Landoulsi, Sonja Jónsdóttir, David Bouvier, Katrin Frauenknecht, Michel Mittelbronn, Roseline Lentz, Jean‐Paul Nicolay, Nadine Jacoby   +127 more
wiley   +1 more source

Multi‐level fatigue reliability assessment of reinforced concrete railway bridges

Structural Concrete, EarlyView.
Abstract This paper presents a multi‐level reliability framework for assessing the fatigue life of reinforced concrete (RC) railway trough bridges subjected to cyclic loading. The framework incorporates increasing levels of analytical complexity and real‐world data in four steps. First, an analytical model applies S–N curves and the Palmgren–Miner rule
Silvia Sarmiento, Jaime Gonzalez‐Libreros, Chao Wang, Lennart Elfgren, Ola Enoksson, Tommy Höjsten, Lars‐Olof Andersson, Gabriel Sas   +7 more
wiley   +1 more source

DNA‐Methylation for Risk‐Stratification of Women Without a Fully Visible Transformation Zone at Colposcopy: A Cross‐Sectional Study

BJOG: An International Journal of Obstetrics &Gynaecology, EarlyView.
ABSTRACT Objective To evaluate the performance of DNA methylation markers for the detection of cervical precancer among screening‐positive older women without a fully visible transformation zone at colposcopy (TZ3). Design Cross‐sectional study. Setting Colposcopy clinics, Central Denmark Region, 2019–2021.
Karen Omann Binderup, Joachim Boers, Line Winther Gustafson, Berit Andersen, Lone Kjeld Petersen, Pinar Bor, Joost Gribnau, Wim G. V. Quint, Henk Van Den Munckhof, Mette Tranberg, Anne Hammer   +10 more
wiley   +1 more source

Case study from Université Claude Bernard, Lyon 1

Open Education Studies, 2022
We present the Active Learning tools introduced in basic mathematics courses in the Preparatory Curriculum for Engineering schools at Université Claude Bernard.
Mercat Christian
doaj   +1 more source

Hunting for Hollanders: The community responsibility system, trade sanctions, and public debt in the late‐medieval Low Countries

The Economic History Review, EarlyView.
Abstract To persuade creditors to lend, cities in the Low Countries relied on a community responsibility system that made all citizens personally liable for public debt. This exposed itinerant citizens to significant risks: their merchandise could be confiscated by creditors, and they could even be imprisoned for debt.
Jaco Zuijderduijn
wiley   +1 more source

Differences in HIV testing may determine the first pillar of the HIV care continuum in a cross‐border setting

HIV Medicine, EarlyView.
Abstract Introduction In border regions like the EuRegio Meuse‐Rhine (EMR), mobility does not stop at the border. HIV risk may therefore not only be determined by within‐country factors but also by between‐country differences. We explored between‐country differences in HIV indicators in the EMR using two complementary data‐driven approaches.
Hanne M. L. Zimmermann, Sarah E. Stutterheim, Dominique van Beckhoven, Wim vanden Berghe, Jessika Deblonde, Sandrine Detandt, Ulrich Marcus, Ben Serrien, Ard van Sighem, Kai J. Jonas   +9 more
wiley   +1 more source

Low breeding propensity in a declining Arctic‐breeding swan revealed by telemetry data

Ibis, EarlyView.
Many migratory bird populations are declining in the face of habitat degradation and climate change, making it important to identify which stages of their annual cycle are most affected in order to guide conservation measures. The Bewick's Swan Cygnus columbianus bewickii, an Arctic‐breeding waterfowl species, has suffered a dramatic population decline
Tohar Tal, Bart A. Nolet, Tom S.L. Versluijs, Judy Z. Shamoun‐Baranes, Götz Eichhorn, Sabine Urban, Hans Linssen   +6 more
wiley   +1 more source

Role of Real Time PCR Quantization in Diagnosis and Prognosis of Leptospirosis and Analysis of the Association between Bacterial Load and Various Complications [PDF]

Journal of Clinical and Diagnostic Research, 2018
Introduction: Leptospirosis is considered as an underreported and underdiagnosed disease. There is paucity of data regarding the incidence of leptospirosis from Mysore, Karnataka. This study throws light into the incidence of leptospirosis and the recent
Linda Rose Jose, Neelambike M Sumana, K Anuradha, B Sumangala   +3 more
doaj   +1 more source

The Ramadan Gambit: The Impact of Fasting on Cognitive Performance

Oxford Bulletin of Economics and Statistics, EarlyView.
ABSTRACT More than 2 billion people participate annually in Ramadan fasting, making its potential effects on cognitive performance important for workplaces, education and high‐stakes decision‐making. We study these effects in tournament chess, an incentivised, real‐world cognitive task in which move quality can be evaluated objectively by a strong ...
Samuel Buckland, David Smerdon
wiley   +1 more source

A Research Paradigm of Weather Index Insurance for Grassland Animal Husbandry: A Pathway to Increased Income for Herders in China’s Inner Mongolia

SAGE Open
This paper aims to theoretically and empirically test whether the Weather Index Insurance for Mutton Sheep (WIMS) which protects the herders from increased feeding costs resulting from drought and snow disasters promotes the income of herders in China’s ...
Gong Yufei, Muhammad Umer Arshad, Guo Xinya, Zhang Xuguang, Zhao Yuanfeng   +4 more
doaj   +1 more source