Results 191 to 200 of about 9,163 (221)

KRT14 Drives Basal Muscle‐Invasive Bladder Cancer Progression and Lung Metastasis by Directly Binding to and Stabilizing IGF2BP1

Advanced Science, EarlyView.
We identified a Krt14+ Igf2bp1+ bladder cancer population linked to EMT. Mechanistically, KRT14 stabilizes and transports IGF2BP1 to invasive protrusions, initiating a positive feedback loop that drives metastasis and poor outcomes. ABSTRACT Basal‐type muscle‐invasive bladder cancer (BMIBC) is characterized by aggressive metastasis and poor prognosis ...
Shirui Huang, Zhihan Zhou, Qipeng Xie, Zheng Wang, Lijiong He, Yutong Liu, Lijuan Huang, Liuxian Ye, Limeng Hu, Baokun Li, Yang Wang, Xiaohui Hua, Xuelei Liu, Yunping Zhao, Jingxia Li, Jinfei Chen, Guiying Wang, Xian Shen, Wei Chen, Chuanshu Huang   +19 more
wiley   +1 more source

Shifts in Antarctic Intermediate Water properties coincide with atmospheric CO₂ rise across the Mid-Brunhes Event. [PDF]

Sci Adv
Tapia R, Ho SL, Nürnberg D, Meckler AN, Iizuka Y, Tiedemann R.   +5 more
europepmc   +1 more source

Leonurine Ameliorates Doxorubicin‐Induced Cardiotoxicity via STING/NF‐κB/NLRP3 Inflammasome Signaling Pathway

Advanced Science, EarlyView.
ABSTRACT Doxorubicin‐induced cardiomyopathy (DIC) remains a dose‐limiting clinical challenge. This study reveals that cardiac vascular endothelial cells (CVECs) act as initial sensors of doxorubicin cardiotoxicity: circulating doxorubicin activates the cGAS‑STING pathway in CVECs, triggering NLRP3 inflammasome‑mediated pyroptosis and release of ...
Wang Jun, Chen Xiaoyang, Xu Jianglin, Yang Zhi, Tao Meijiao, He Jiale, Zhao Jiangfeng, Hei Xuanding, Xu Xuegong, Wang Wei, Li Chun   +10 more
wiley   +1 more source

Leveraging geographic information system for dengue surveillance: a scoping review. [PDF]

Trop Med Health
Prakash Nayak P, Pai B J, Govindan S.
europepmc   +1 more source

CCT2 Promotes Prostate Cancer Progression Through EIF3F‐Dependent Stabilization of FASN

Advanced Science, EarlyView.
ABSTRACT Prostate cancer (PCa) is increasingly recognized to be driven by dysregulated lipid metabolism. Although fatty acid synthase (FASN) is highly expressed in PCa, the mechanisms governing FASN protein stability and its functional integration into oncogenic lipid metabolism remain poorly defined.
Shun Xu, Yifan Zhang, Haolin Li, Shengyu Zhao, Xiaoran Dai, Qili Xu, Mintian Fei, Chun Li, Zhihui Zou, Baojun Wang, Li Zhang, Hui Wang, Ligang Zhang, Chaozhao Liang   +13 more
wiley   +1 more source

A framework for modelling desert locust population dynamics and large-scale dispersal. [PDF]

PLoS Comput Biol
Retkute R, Thurston W, Cressman K, Gilligan CA.   +3 more
europepmc   +1 more source

Understanding the mechanisms of climate change impact on tuberculosis: a complex systems approach. [PDF]

BMC Public Health
Shadi Y, Morasae EK, Khazaei S, Nasehi M, Sharafi S, Asakereh H, Tapak L, Kahramfar Z, Mohammadi Y.   +8 more
europepmc   +1 more source

Genetic and wind field analysis of wheat leaf rust (<i>Puccinia triticina</i>) dispersal: from winter sources in Gansu and Shaanxi to summer epidemics in China. [PDF]

Front Plant Sci
Li H, Zhao N, Zhang Q, Huang L, Zhang H, Gao L, Chen W, Liu T.   +7 more
europepmc   +1 more source

The diversity of lepidopteran spatial orientation strategies - neuronal mechanisms and emerging challenges in a changing world. [PDF]

J Comp Physiol A Neuroethol Sens Neural Behav Physiol
Grob R, Farnworth MS, Degen J, Warrant E, Montgomery SH, El Jundi B.   +5 more
europepmc   +1 more source

Impact of climate change on the tick-host-pathogen complex: distribution patterns, disease incidence, and host infestation. [PDF]

Rev Bras Parasitol Vet
Alasmari SMN, Tu CW, Khan M, Javed B, Liaqat I, Bahadar S, Altwaim SA, Chen CC, Vaz Junior IDS, Ali A.   +9 more
europepmc   +1 more source