Results 41 to 50 of about 38,051 (214)

Analysis of the Year-Round Operation of Enhanced Natural Ventilation Systems under Transient Weather Conditions in Europe

open access: yesEnergies
This study presents the potential of using a natural ventilation system integrated with different combinations of enhancement techniques. The focus was on the perspective of using such configurations of passive ventilation systems (PVSs) in buildings ...
Rafał Andrzejczyk
doaj   +1 more source

Artificial molecular machines and motors—Design and control of nanoscale motion

open access: yesFEBS Letters, EarlyView.
Molecules are constantly moving because of thermal fluctuations, but random motion alone cannot be exploited to perform directional tasks. Artificial molecular machines use chemical, electrical, or light energy to bias this motion. Molecular shuttles, rotary motors, and supramolecular pumps illustrate how nanoscale movement can be controlled and ...
Leonardo Andreoni, Alberto Credi
wiley   +1 more source

Magnetospheric balance of solar wind dynamic pressure

open access: yesGeophysical Research Letters, 2017
The magnetopause is the boundary established by pressure balance between the solar wind flow in the magnetosheath and the magnetosphere. Generally, this pressure balance is represented to be between the solar wind, the dynamic pressure, and the magnetic ...
Ramon E. Lopez, Walter D. Gonzalez
doaj   +1 more source

Invisible but not inaccessible—Revealing transient oligomers formed by intrinsically disordered proteins with solution NMR and complementary methods

open access: yesFEBS Letters, EarlyView.
Transient oligomers formed by intrinsically disordered proteins may be ‘invisible’ to direct detection yet remain accessible to solution NMR through equilibrium‐exchange measurements and pressure‐jump experiments. Complementary methods report on mass, stoichiometry, selected distance distributions, morphology, and internal packing.
Martin D. Gelenter, Ad Bax
wiley   +1 more source

Evaluation of the impact force of the window stopper components strength with plastic material operating under wind gust

open access: yesNihon Kikai Gakkai ronbunshu, 2015
In recent years, the potential for oscillation of swing-type windows due to wind gusts, with accompanying breakage of stopper components and glass, has come under consideration.
Gaku NISHIE, Takao MORI
doaj   +1 more source

Membrane composition and thermodynamic identity as boundaries of life for synthetic cell research

open access: yesFEBS Letters, EarlyView.
What makes a cell a cell? The boundary of a living cell is not just a wall. Read as a Markov blanket, the membrane separates internal from external states, generating identity and non‐equilibrium order. Can this identity be rebuilt from scratch in a synthetic cell?
Caterina Presutti, Bert Poolman
wiley   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

Digital twin-driven method for determining wind force coefficients of a bridge deck section

open access: yesEngineering Applications of Computational Fluid Mechanics
Wind force coefficients are important parameters for aerostatic and aerodynamic analyses in wind-resistant design of a long-span bridge. Wind force coefficients of long-span bridges are currently obtained through wind tunnel tests or computational fluid ...
Hao-Yang Li   +4 more
doaj   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

open access: yesMolecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington   +10 more
wiley   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

open access: yesMolecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq   +8 more
wiley   +1 more source

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