Results 51 to 60 of about 25,038 (263)

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Western Wind and Solar Integration Study: Hydropower Analysis [PDF]

, 2012
The U.S. Department of Energy's (DOE) study of 20% Wind Energy by 2030 was conducted to consider the benefits, challenges, and costs associated with sourcing 20% of U.S. energy consumption from wind power by 2030. This study found that with proactive measures, no insurmountable barriers were identified to meet the 20% goal.
Acker, T., Pete, C.
openaire   +2 more sources

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

Nebraska Statewide Wind Integration Study: April 2008 – January 2010 [PDF]

, 2010
Wind generation resources in Nebraska will play an increasingly important role in the environmental and energy security solutions for the state and the nation. In this context, the Nebraska Power Association conducted a state-wide wind integration study.
Clint Johannes, Doug Kallesen
openaire   +4 more sources

CFD-Driven Design Optimization of Corrugated-Flange Diffuser-Integrated Wind Turbines for Enhanced Performance

Energies
In the global shift toward sustainable energy, enhancing the efficiency of renewable energy systems plays a pivotal role in advancing the Sustainable Development Goals.
Debela Alema Teklemariyem, Nasir Hussain Razvi Syed, Phong Ba Dao   +2 more
doaj   +1 more source

A Markov-Switching Vector Autoregressive Stochastic Wind Generator for Multiple Spatial and Temporal Scales

Resources, 2015
Despite recent efforts to record wind at finer spatial and temporal scales, stochastic realizations of wind are still important for many purposes and particularly for wind energy grid integration and reliability studies. Most instances of wind generation
Amanda S. Hering, Karen Kazor, William Kleiber   +2 more
doaj   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Scenario-Based Optimal Power Flow Evaluation for Wind Power Allocation Capacity in Modern Power Systems

IEEE Access
Integrating wind power into modern energy grids presents significant challenges due to its unpredictable nature. This study introduces a scenario-based optimal power flow model with Wind Farms Optimal Capacity in Grid (SOPF-WOCG) to enhance system ...
Aamer A. Shah, Shuchen Wang, Gai Liu, Rizwan Ul Hassan, Aamir Nawaz   +4 more
doaj   +1 more source

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

Small signal stability analysis of power systems with high penetration of wind power

Journal of Modern Power Systems and Clean Energy, 2013
The integration of large amount of wind power into a power system imposes a new challenge for the secure and economic operation of the system. It is necessary to investigate the impacts of wind power generation on the dynamic behavior of the power system
Ping He, Fushuan Wen, Gerard Ledwich, Yusheng Xue   +3 more
doaj   +1 more source